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Neil R Chappell, Beth Zhou, Amy K Schutt, William E Gibbons and Chellakkan S Blesson

metabolic components of this model, research on the reproductive system of these animals, in particular the oocyte itself, remains sparse. Prior studies have shown impaired mitochondrial function with hyperandrogenic environments in the oocyte to have

Open access

Masafumi Tetsuka and Misato Tanakadate

Introduction The preovulatory LH surge triggers dynamic changes in the ovulatory follicle leading to a follicular rupture and subsequent luteinization. This ovulatory process takes some 24 h in cattle, during which the ovulating oocyte and

Open access

Rosalie Cabry, Philippe Merviel, Aicha Madkour, Elodie Lefranc, Florence Scheffler, Rachel Desailloud, Veronique Bach and Moncef Benkhalifa

The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men, and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (i) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects, and poor IVF outcomes, and (ii) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates and elevated risk of miscarriage associated with exposure to high doses of pesticides.

Open access

Hui Long, Yanhong Nie, Li Wang, Yong Lu, Yan Wang, Yijun Cai, Zhen Liu, Miaomiao Jia, Qifeng Lyu, Yanping Kuang and Qiang Sun

nuclear transfer and the embryo stem cell establishment ( 4 , 5 ). These achievements were dependent on an amount of oocytes retrieval in ovarian stimulation. However, ovarian stimulation regimen in nonhuman primates has not been set up as well as human

Open access

Wioletta Pijacka, Morag G Hunter, Fiona Broughton Pipkin and Martin R Luck

91523 and ab91522 (Abcam). Kidney was used as a positive control. Oocyte collection and in vitro maturation Bovine ovaries were obtained from a local abattoir and transported to the laboratory in thermal containers containing 1× PBS at 39 °C. Cumulus–oocyte

Open access

Wolfgang Koechling, Daniel Plaksin, Glenn E Croston, Janni V Jeppesen, Kirsten T Macklon and Claus Yding Andersen

cell line stably expressing the human FSH receptor, and in human granulosa cells isolated during oocyte pick-up prior to IVF. The pharmacokinetic behavior of the two rFSH proteins was also analyzed in rodents, examining the role of the ASGP receptor in

Open access

Lian Hollander-Cohen, Benjamin Böhm, Krist Hausken and Berta Levavi-Sivan

cFSHR and LHCGR and studied their expression profile throughout the annual reproductive cycle. We then aimed to study the specific role of each of the carp gonadotropins at the final stages of oocyte maturation. We further studied the promiscuity of the

Open access

Kaisu Luiro, Kristiina Aittomäki, Pekka Jousilahti and Juha S Tapanainen

pregnancy using donated oocytes ( 7 ). Adverse long-term health outcomes of POI have been indicated in several epidemiological and observational studies ( 8 , 9 , 10 , 11 ). POI is associated with shortened life expectancy and increased mortality mainly

Open access

Arpna Sharma, Vijay Simha Baddela, Frank Becker, Dirk Dannenberger, Torsten Viergutz and Jens Vanselow

excessive lipid mobilization has been associated with metabolic and reproductive disorders ( 3 ) affecting both the cumulus oocyte complex morphology and embryo viability ( 4 ). Elevated plasma levels of PA, SA, OA and of linoleic acid have been shown in

Open access

Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou and David Møbjerg Kristensen

( 1 , 19 ). PGCs are diploid stem cells responsible for giving rise to the germline in both males and females. Thus, they are the precursors of oocytes and spermatozoa in the ovaries and testes, respectively ( 20 ). PGCs arise in the extraembryonic