Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by Felix Haglund in
Google Scholar
PubMed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by Gustaf Rosin in
Google Scholar
PubMed
Search for other papers by Inga-Lena Nilsson in
Google Scholar
PubMed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by C Christofer Juhlin in
Google Scholar
PubMed
Search for other papers by Ylva Pernow in
Google Scholar
PubMed
Search for other papers by Sophie Norenstedt in
Google Scholar
PubMed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by Andrii Dinets in
Google Scholar
PubMed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by Catharina Larsson in
Google Scholar
PubMed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by Johan Hartman in
Google Scholar
PubMed
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Search for other papers by Anders Höög in
Google Scholar
PubMed
parathyroid adenoma. As parathyroid adenomas are frequently found in postmenopausal women, a causality coupled to female hormones or their receptors was proposed at an early stage. Oestrogens are a group of steroid hormones with important reproductive
Search for other papers by Anne M Drewes in
Google Scholar
PubMed
Search for other papers by Maria E Møller in
Google Scholar
PubMed
Search for other papers by Rasmus Hertzum-Larsen in
Google Scholar
PubMed
Search for other papers by Gerda Engholm in
Google Scholar
PubMed
Search for other papers by Hans H Storm in
Google Scholar
PubMed
increased risk of brain tumour in premenopausal women with breast cancer and a protective effect in postmenopausal women, hormonal levels (oestrogen and progesterone) could possibly have a role in the risk for developing a second primary brain tumour
Division of Exercise Science and Sport Medicine, Department of Human Biology, University of Cape Town, 3 Floor Sports Science Institute of South Africa Cape Town, South Africa
Search for other papers by Julia H Goedecke in
Google Scholar
PubMed
Search for other papers by Mehreen Tootla in
Google Scholar
PubMed
Search for other papers by Dheshnie Keswell in
Google Scholar
PubMed
Introduction Sex hormones are important determinants of regional body fat distribution, as evidenced by gender differences in body fat distribution. Indeed, an increase in oestrogen levels are related to greater gynoid body fat deposition ( 1
Search for other papers by Jennifer K Y Ko in
Google Scholar
PubMed
Search for other papers by Thomas F J King in
Google Scholar
PubMed
Search for other papers by Louise Williams in
Google Scholar
PubMed
Search for other papers by Sarah M Creighton in
Google Scholar
PubMed
Search for other papers by Gerard S Conway in
Google Scholar
PubMed
Berglund and coworkers, 64/78 women with AIS were on HRT and the median age at first prescription of HRT was 14 years ( 1 ). Sex steroid replacement has traditionally been based on types of oestrogen, but there is increasing interest from user groups in the
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Jasmin Asberger in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Thalia Erbes in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Markus Jaeger in
Google Scholar
PubMed
Search for other papers by Gerta Rücker in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Claudia Nöthling in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Andrea Ritter in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Kai Berner in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Search for other papers by Ingolf Juhasz-Böss in
Google Scholar
PubMed
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Institute of Veterinary Medicine, Georg-August-University Goettingen, Goettingen, Germany
Search for other papers by Marc Hirschfeld in
Google Scholar
PubMed
Introduction With an incidence of 28.2%, breast cancer represents the most common type of cancer in females in Europe ( 1 ). Oestrogen-dependent gene expression regulation is known to play an important role in the promotion and progression of
Search for other papers by Nancy Martini in
Google Scholar
PubMed
Search for other papers by Lucas Streckwall in
Google Scholar
PubMed
Search for other papers by Antonio Desmond McCarthy in
Google Scholar
PubMed
turn, depends on the balance between (i) procalcifying factors, such as type 2 bone morphogenic protein (BMP2), RANKL, hyperphosphataemia, hypercalcaemia, oxidative stress, subendothelial accumulation of advanced glycation end-products (AGEs), oestrogen
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Search for other papers by Kirsty G Pringle in
Google Scholar
PubMed
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Search for other papers by Sarah J Delforce in
Google Scholar
PubMed
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Search for other papers by Yu Wang in
Google Scholar
PubMed
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Search for other papers by Katie A Ashton in
Google Scholar
PubMed
Search for other papers by Anthony Proietto in
Google Scholar
PubMed
Search for other papers by Geoffrey Otton in
Google Scholar
PubMed
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Search for other papers by C Caroline Blackwell in
Google Scholar
PubMed
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Division of Molecular Medicine, Pathology North, Newcastle, New South Wales, Australia
Search for other papers by Rodney J Scott in
Google Scholar
PubMed
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Search for other papers by Eugenie R Lumbers in
Google Scholar
PubMed
mouse model of EC ( 5 ). Increased expression of Ang II, AGTR1, AGTR2, VEGFA and oestrogen receptor alpha (NR3A1) has been identified in EC tissues ( 13 ). In addition, high positive correlations have been identified between the expression of Ang II
Search for other papers by Sakina Kherra in
Google Scholar
PubMed
Search for other papers by Wendy Forsyth Paterson in
Google Scholar
PubMed
Search for other papers by Filiz Mine Cizmecioglu in
Google Scholar
PubMed
Search for other papers by Jeremy Huw Jones in
Google Scholar
PubMed
Search for other papers by Mariam Kourime in
Google Scholar
PubMed
Search for other papers by Heba Hassan Elsedfy in
Google Scholar
PubMed
Search for other papers by Sameh Tawfik in
Google Scholar
PubMed
Search for other papers by Andreas Kyriakou in
Google Scholar
PubMed
Search for other papers by Mohamad Guftar Shaikh in
Google Scholar
PubMed
Search for other papers by Malcolm David Cairns Donaldson in
Google Scholar
PubMed
monthly norethisterone for 4 and 15 months before starting oestrogen treatment. By the end of the study period, only 5 of the 24 patients with primary amenorrhoea aged > 14 years had been treated with oestrogen: one with oestradiol valerate
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
Search for other papers by Laurent Maïmoun in
Google Scholar
PubMed
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
Search for other papers by Denis Mariano-Goulart in
Google Scholar
PubMed
Search for other papers by Helena Huguet in
Google Scholar
PubMed
CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
Search for other papers by Eric Renard in
Google Scholar
PubMed
Search for other papers by Patrick Lefebvre in
Google Scholar
PubMed
CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Search for other papers by Marie-Christine Picot in
Google Scholar
PubMed
Search for other papers by Anne-Marie Dupuy in
Google Scholar
PubMed
Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
Search for other papers by Jean-Paul Cristol in
Google Scholar
PubMed
Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
Search for other papers by Philippe Courtet in
Google Scholar
PubMed
Search for other papers by Vincent Boudousq in
Google Scholar
PubMed
Search for other papers by Antoine Avignon in
Google Scholar
PubMed
Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
Search for other papers by Sébastien Guillaume in
Google Scholar
PubMed
Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
Search for other papers by Ariane Sultan in
Google Scholar
PubMed
activities. Neither control subjects nor anorexic patients presented with primary amenorrhoea or were taking any medications that were known to affect bone metabolism, particularly prolonged glucocorticoid use (>3 months) or oestrogen , vitamin K, vitamin D
Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa, Tokyo, Japan
Search for other papers by Yusaku Mori in
Google Scholar
PubMed
Search for other papers by Eunhyoung Ko in
Google Scholar
PubMed
Search for other papers by Rudolf Furrer in
Google Scholar
PubMed
Search for other papers by Linda C Qu in
Google Scholar
PubMed
Search for other papers by Stuart C Wiber in
Google Scholar
PubMed
Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Division of Endocrinology and Metabolism, Leadership Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by I George Fantus in
Google Scholar
PubMed
Search for other papers by Mario Thevis in
Google Scholar
PubMed
Department of Pathology, Humber River Regional Hospital, Toronto, Ontario, Canada
Search for other papers by Alan Medline in
Google Scholar
PubMed
Search for other papers by Adria Giacca in
Google Scholar
PubMed
commonest condition of insulin resistance, that is, after high-fat diet. We used a model of oestrogen-dependent carcinoma (commonest form of breast cancer), the N-methyl-N-nitrosourea (MNU)-induced mammary tumour model ( 27 ). Materials and methods