Department of Endocrinology and Internal Medicine, Novo Nordisk A/S, NNF center for Basic Metabolic Research, Department of Clinical Biochemistry, Department of Clinical Physiology and Molecular Imaging, Department of Clinical Medicine, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Novo Nordisk A/S, NNF center for Basic Metabolic Research, Department of Clinical Biochemistry, Department of Clinical Physiology and Molecular Imaging, Department of Clinical Medicine, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus, Denmark
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vasorelaxant effects (7) . A recently published article by Kim et al . (8) reports that atrial natriuretic peptide (ANP) mediates the antihypertensive effects of GLP1 in mice. The authors convincingly demonstrate that GLP1R activation stimulates ANP release
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Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Introduction Two male patients with type 2 diabetes (T2D) and coronary heart disease had plasma levels of brain natriuretic peptide (BNP) and N-terminal probrain natriuretic peptide (NT-proBNP) measured as part of routine evaluation. Both were
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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cognate receptors induces lipolysis and increased energy expenditure (3, 4, 5, 6) . A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) act through a common receptor, natriuretic peptide receptor-A (NPR-A), and a clearance receptor, NPR
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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endothelium could have a place in the work-up of patients. Adrenomedullin (ADM), atrial natriuretic peptide (ANP) and copeptin are all associated with CVD and part of the delicate system controlling fluid and hemodynamic homeostasis through vascular tonus and
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Department of Health Sciences, Department of Epidemiology and Biostatistics, Department of Public Health, Department of General Practice, Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Department of Internal Medicine, Faculty of Earth and Life Sciences, EMGO Institute for Health and Care Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
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improvements in endothelial function (4, 5, 6) . Plasma B-type natriuretic peptide (BNP) is a neurohormone that is primarily secreted in the cardiomyocytes in response to ventricular stretch and pressure overload, so the BNP level is determined by many aspects
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) . Subsequently, in 1983, a polypeptide named atrial natriuretic factor (ANF) or atrial natriuretic peptide (ANP) was isolated, purified and sequenced from rat atrial extracts (10, 11, 12) . The following year, ANF was isolated from human atria (13) . The
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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(ANP) and B-type (BNP) natriuretic peptides ( 2 ). Increased plasma concentrations of natriuretic peptides counteract the detrimental circulatory effects of heart failure, as they improve cardiac pre- and afterload by enhancing renal excretion of sodium
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-terminal pro-B-type natriuretic peptide (NT-proBNP), is a biologically inactive, 76-amino acid-long prohormone used as a diagnostic biomarker for heart failure ( 20 ). Its use as a diagnostic and prognostic biomarker has also been described in CS and CHD by a
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Department of Veterinary Clinical and Animal Sciences, Novo Nordisk A/S, Department of Clinical Biochemistry, Department of Cardiothoracic and Vascular Surgery, Department of Clinical Biochemistry, Department of Veterinary Disease Biology, Department of Clinical Chemistry, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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brain natriuretic peptides (ANP and BNP) are useful in the diagnosis of canine heart failure and may also aid in the detection of severe preclinical MR (5) . Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS
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Department of Cardiology, Yanbian University Hospital, Yanji, China
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to diabetes and obesity ( 6 , 7 ). GLP-1R is located in the atria of the heart and can regulate the secretion of various hormones. Atrial natriuretic peptide (ANP) is a cardiac endocrine with a role in lowering blood pressure by regulating the