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Vittorio Unfer Health Department, UniPoliSi – Institut des Etudes Universitaires, Disentis, Switzerland

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Fabio Facchinetti Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy

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Beatrice Orrù Medical Affairs Department, Lo.Li. Pharma, Rome, Italy

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Barbara Giordani Medical Affairs Department, Lo.Li. Pharma, Rome, Italy

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John Nestler Departments of Medicine and Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, USA

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Introduction Myo-inositol (MI) is one stereoisomer of a C 6 sugar alcohol that belongs to the inositol family ( 1 ). It is the precursor of inositol triphosphate, acting as an intracellular second messenger and regulating a number of hormones

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Yiqiong Ma Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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Zhaowei Chen Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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Yu Tao Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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Jili Zhu Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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Hongxia Yang Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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Wei Liang Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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Guohua Ding Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

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M Victor VM . Mitochondrial dynamics in type 2 diabetes: pathophysiological implications . Redox Biology 2017 637 – 645 . ( https://doi.org/10.1016/j.redox.2017.01.013 ) 22 Sun L Dutta RK Xie P Kanwar YS . Myo-inositol oxygenase

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Laura Potasso Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Julie Refardt Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland

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Irina Chifu Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg Germany

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Martin Fassnacht Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg Germany
Central Laboratory, University Hospital Wuerzburg, Wuerzburg, Germany

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Wiebke Kristin Fenske Integrated Research and Treatment Center for Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany
Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany

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Mirjam Christ-Crain Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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osmolytes (e.g. glutamine and other aminoacids, glutamate, taurine, myo-inositol, etc.) are synthetized or shifted into ICF, and the previously internalized potassium is released back to extracellular fluid (ECF). As adaption to a chronic hyperosmolar state

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Qian Deng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Yue Zhu Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Mengmeng Zhang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Aihua Fei Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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Jiaqi Liang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Jinjin Zheng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Qingping Zhang College of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China

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Tong Cheng Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China

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Xia Ge Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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. ( https://doi.org/10.1089/ars.2016.6665 ) 35 Deng F Sharma I Dai Y Yang M Kanwar YS . myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule . Journal of Clinical Investigation 2019 129 5033

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