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Carolina Inda, Natalia G Armando, Paula A dos Santos Claro and Susana Silberstein

signaling from intracellular compartments. We present a brief overview of important aspects of the CRH pathophysiology for which the identification of novel molecular components and mechanisms of CRHRs signaling will impact on development of therapies for

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Fernando Aprile-Garcia, María Antunica-Noguerol, Maia Ludmila Budziñski, Ana C Liberman and Eduardo Arzt

understanding of the molecular mechanism leading to the antagonic effect of these two regulators may provide novel targets in the neuroendocrine control of inflammation. Declaration of interest The authors declare that there is no conflict of interest that could

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Luigi Laino, Silvia Majore, Nicoletta Preziosi, Barbara Grammatico, Carmelilia De Bernardo, Salvatore Scommegna, Anna Maria Rapone, Giacinto Marrocco, Irene Bottillo and Paola Grammatico

Introduction Sex development is a multistep process under genetic control, implying a delicate network of molecular events that direct both the bi-potential gonads to become either a testis or an ovary (sex determination), and the consequent

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Doron Weinstein, Rive Sarfstein, Zvi Laron and Haim Werner

therapeutics to co-target IGF1R and INSR in PCa. Finally, further research is needed to examine additional mitogenic activities induced by insulin relevant to PCa development and progression, and to explore the molecular mechanism of INSR expression and

Open access

Eric Seidel, Gudrun Walenda, Clemens Messerschmidt, Benedikt Obermayer, Mirko Peitzsch, Paal Wallace, Rohini Bahethi, Taekyeong Yoo, Murim Choi, Petra Schrade, Sebastian Bachmann, Gerhard Liebisch, Graeme Eisenhofer, Dieter Beule and Ute I Scholl

). Because SOAT catalyzes the generation of cholesterol esters from free sterol and acyl CoA ( 14 ), inhibition of its activity has been proposed to result in elevated levels of free cholesterol, ER stress and apoptosis. The molecular mechanisms of acquired

Open access

N K Stepto, D Hiam, M Gibson-Helm, S Cassar, C L Harrison, S K Hutchison, A E Joham, B J Canny, A Moreno-Asso, B J Strauss, N Hatzirodos, R J Rodgers and H J Teede

not normalisation of phosphorylation defects by training. Overall, these data and that of others ( 9 , 10 ) suggests insulin signalling defects in skeletal muscle account for some insulin resistance, but additional molecular mechanisms are responsible

Open access

Qi Che, Xirong Xiao, Jun Xu, Miao Liu, Yongning Lu, Suying Liu and Xi Dong

mechanism of cancer proliferation and invasion bio-behavior will be of great significance for the clinical treatment of malignant tumor patients. As one of the most important hormone-dependent cancers, the tumorigenesis and progression of endometrial

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Legh Wilkinson, Nicolette J D Verhoog and Ann Louw

is given to disease- or treatment-associated reductions in the GRα pool, which drive the development of GC insensitivity, followed by the molecular mechanisms involved in mediating these reductions. Furthermore, current methods to restore GRα protein

Open access

Emma Jernberg, Anders Bergh and Pernilla Wikström

-regulators, activators and repressors, interact with and facilitate the activity of different AR-Vs. Origin of truncated AR variants The molecular mechanisms mediating increased levels of truncated AR-Vs in CRPC tumour epithelial cells still need to be clarified

Open access

Melissa Braga, Zena Simmons, Keith C Norris, Monica G Ferrini and Jorge N Artaza

targeting skeletal muscle stem cells, and to determine the associated molecular mechanism(s). This was done by investigating the expression of key pro- and anti-cell differentiation lineage markers and select growth factors modulated by 1,25-D 3 in primary