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Pernille Bækgaard Udesen The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark
Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Dorte Glintborg Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Anja Elaine Sørensen Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Rikke Svendsen Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Nanna Louise Skov Nielsen Department of Science and Environment, Roskilde University, Roskilde, Denmark
Department of Clinical Immunology, Næstved Hospital, Næstved, Denmark

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Marie Louise Muff Wissing Aleris Hamlet Hospital Group, The Fertility Clinic, Søborg, Denmark

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Marianne Skovsager Andersen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Anne Lis Mikkelsen Englund The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark

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Louise Torp Dalgaard Department of Science and Environment, Roskilde University, Roskilde, Denmark

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well as many different miRNAs. Some of these miRNAs (e.g. miR-122, miR-223) are believed to have a more pronounced role than others, as several studies confirm their associations ( 15 , 16 ). miRNAs are produced in cells of various tissues and serve as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0195
Volume/Issue:
Volume 9: Issue 11
Open access
Devis Pascut Fondazione Italiana Fegato – ONLUS, Trieste, Italy

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Sofia Tamini Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy

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Silvia Bresolin Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy

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Pablo Giraudi Fondazione Italiana Fegato – ONLUS, Trieste, Italy

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Giuseppe Basso Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy

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Alessandro Minocci Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

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Claudio Tiribelli Fondazione Italiana Fegato – ONLUS, Trieste, Italy

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Graziano Grugni Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

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Alessandro Sartorio Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

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10% top expressed circulating miRNome with a log2 fold change (FC) greater than 5 (Supplementary Table 4). Among the highly expressed miRNA in serum, miR-92a-3p, mir-122, miR-185-5p, 191-5p were implicated in lipid metabolism and their association

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0329
Volume/Issue:
Volume 7: Issue 12
Open access
Taís S Assmann Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Mariana Recamonde-Mendoza Institute of Informatics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Bianca M De Souza Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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Daisy Crispim Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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different diseases. Due to its downregulation in certain cancers, miR-1275 has been referred to as a tumor suppressor ( 122 , 123 , 124 , 125 ). In a HuH-7 hepatocarcinome cell line, miR-1275 overexpression suppressed IGF2BP expression, effectively

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0248
Volume/Issue:
Volume 6: Issue 8
Open access
Bingbing Wang Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

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Mayra Cruz Ithier Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

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Nataliya Parobchak Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

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Stacy M Yadava Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

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Jay Schulkin Department of Obstetrics, Gynecology, University of Washington, Seattle, Washington, USA

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Todd Rosen Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

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of genomic loci associated with VDR stimulated by 1,25(OH)2D ( P  < 0.05). Number of genomic loci Chromosomes Non-coding RNA genes 1112 1–22, X, Y  MicroRNAs 542 1–22, X, Y  Others 570 1–22, X, Y

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0345
Volume/Issue:
Volume 7: Issue 12
Open access
E R Polina Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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F M Oliveira Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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R C Sbruzzi Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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D Crispim Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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L H Canani Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

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K G Santos Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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(mmol/L) 1.22 (1.03–1.44) 0.024 Plasma levels of miR-155 in blood donors and T2DM patients with and without DR To evaluate the plasma levels of miR-155, 20 samples were randomly selected from each group of T2DM patients. Patients

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0446
Volume/Issue:
Volume 8: Issue 12
Open access
Jiwen Yang Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China

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Yayin Huang Department of Clinical Laboratory, The Second People’s Hospital of Wuhu, Wuhu City, Anhui Province, China

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Bohan Dong Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu City, Anhui Province, China

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Yunhai Dai Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China

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Highlights lncRNA DLEU2 is significantly upregulated in thyroid cancer tissues and cell lines. DLEU2 accelerates the proliferation, migration and aerobic glycolysis while inhibits the apoptosis of thyroid cancer cells. miR-205

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0046
Volume/Issue:
Volume 10: Issue 4
Open access
Qiuyu Huang Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China

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Hanshen Chen Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China

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Fan Xu Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China

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Chao Liu Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

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Yafeng Wang Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China

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Weifeng Tang Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing University Medical School, Jiangsu Province, China

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Liangwan Chen Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian Province, China

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.05 0.88 (0.39–2.01) 0.767 0.90 (0.39–2.08) 0.813  G allele 143 14.39 233 14.90 miR-146a rs2910164  CC 187 37.63 308 39.39 1.00 1.00  CG 258 51.91 349 44.63 1.22 (0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0261
Volume/Issue:
Volume 10: Issue 11
Open access
Elena Valassi Endocrinology/Medicine Department, Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Natalia García-Giralt URFOA, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autònoma de Barcelona, Barcelona, Spain

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Jorge Malouf Mineral Metabolism Unit, Medicine Department, Hospital Sant Pau, Barcelona, Spain

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Iris Crespo Endocrinology/Medicine Department, Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Jaume Llauger Radiology Department, Hospital Sant Pau, Barcelona, Spain

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Adolfo Díez-Pérez URFOA, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autònoma de Barcelona, Barcelona, Spain

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Susan M Webb Endocrinology/Medicine Department, Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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.006 −1.88 ± 0.008 −1.2 0.17 0.35 hsa-miR-324-5p −0.44 ± 0.008 −4.77 ± 0.008 1.23 0.17 0.35 hsa-miR-29a-3p −2.65 ± 0.006 −2.43 ± 0.007 −1.16 0.23 0.43 hsa-miR-122-5p −1.88 ± 1.02 −0.15 ± 0.13 −0.12 0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0482
Volume/Issue:
Volume 8: Issue 1
Open access
Magnolia Ariza-Nieto Cornell University, Meinig School of Biomedical Engineering, Ithaca, New York, USA
epiWELL, LLC, Ithaca, New York, USA

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Joshua B Alley Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Sanjay Samy Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Laura Fitzgerald Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Francoise Vermeylen Cornell University, Cornell Statistical Consulting Unit, Ithaca, New York, USA

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Michael L Shuler Cornell University, Meinig School of Biomedical Engineering, Ithaca, New York, USA

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José O Alemán New York University Langone Medical Center, New York, New York, USA

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critical changes in the expression and function of genes. The presence of MIR148A has been associated with DNA hypomethylation caused by sequence complementarity between MIR148A and DNMT1 ( 15 , 16 , 17 ). MicroRNAs in general have large amounts of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0205
Volume/Issue:
Volume 7: Issue 9
Open access
Marco Marino Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Valentina Cirello Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Valentina Gnarini Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Carla Colombo Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Elisa Pignatti Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Livio Casarini Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Chiara Diazzi Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Vincenzo Rochira Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Katia Cioni Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Bruno Madeo Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Cesare Carani Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Manuela Simoni Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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Laura Fugazzola Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy
Unit and Chair of Endocrinology and Metabolism, Center for Genomic Research, Department of Clinical Sciences and Community Health, Endocrine Unit, Azienda USL of Modena, NOCSAE, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Pietro Giardini 1355, 41126 Modena, Italy

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blood sample for association studies on thyroid cancers. The study protocol was approved by the Local Ethics Committee (file no. 122/08). Criteria for the selection of SNPs We selected the rs2910164 SNP of the pre-miR-146a gene because of its direct

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0066
Volume/Issue:
Volume 2: Issue 4
Open access