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Metformin ameliorates body mass gain and early metabolic changes in ovariectomized rats

Clarissa Souza Barthem, Camila Lüdke Rossetti, Denise P Carvalho, and Wagner Seixas da-Silva

. Ovariectomy is frequently used in literature for a better understanding of metabolic disorders of menopause ( 6 , 7 ), and for testing pharmacological alternatives to prevent menopause disturbances ( 8 , 9 ). During recent decades, the biguanide metformin

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Metformin decreases miR-122, miR-223 and miR-29a in women with polycystic ovary syndrome

Pernille Bækgaard Udesen, Dorte Glintborg, Anja Elaine Sørensen, Rikke Svendsen, Nanna Louise Skov Nielsen, Marie Louise Muff Wissing, Marianne Skovsager Andersen, Anne Lis Mikkelsen Englund, and Louise Torp Dalgaard

lifestyle management ( 1 ), however medical treatment with metformin and/or oral contraceptive pills (OCPs) is often considered necessary. Metformin reduces insulin resistance, decreases insulin levels and improves dyslipidemia in women with PCOS, especially

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Long-term efficacy of metformin in overweight-obese PCOS: longitudinal follow-up of retrospective cohort

Mojca Jensterle, Nika Aleksandra Kravos, Simona Ferjan, Katja Goricar, Vita Dolzan, and Andrej Janez

clinical predictors of progressive metabolic burden ( 2 ). Metformin that has been used in PCOS over the past few decades ( 3 , 4 ) may decrease the metabolic risk ( 1 ), yet the majority of therapeutic studies in this population have been small and have

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Predictors of metformin monotherapy failure in gestational diabetes mellitus

Vânia Benido Silva, Liliana Fonseca, Maria Teresa Pereira, Joana Vilaverde, Clara Pinto, Fernando Pichel, Maria do Céu Almeida, and Jorge Dores

, metformin has emerged as a very attractive oral therapeutic alternative, with several studies proving its positive impact on glycemic control and its easier administration ( 1 , 12 ). Furthermore, it has been shown that, compared to insulin, metformin is

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A breakthrough-like effect of metformin reduces peripheral resistance to triiodothyronine in euthyroid, non-insulin-resistant, type 2 diabetic patients

Melinda Kertész, Szilárd Kun, Eszter Sélley, Zsuzsanna Nagy, Tamás Kőszegi, and István Wittmann

level, blood pressure, and heart rate) should also be measured. Metformin is used in prediabetes and in type 2 diabetic patients to treat insulin resistance resulting in a decreased level of plasma glucose and triglycerides, leading in this way to a

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Metformin improves the glucose homeostasis of Wuchang bream fed high-carbohydrate diets: a dynamic study

Chao Xu, Xiang-Fei Li, Hong-Yan Tian, Hua-Juan Shi, Ding-Dong Zhang, Kenneth Prudence Abasubong, and Wen-Bin Liu

expressions of lipogenic genes ( 16 , 17 ). Until now, extensive studies have confirmed that the activity of AMPK can be modulated by the phosphorylation of a threonine at position 172 (Thr172) in the α-subunit ( 18 , 19 ). As an activator of AMPK, metformin

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Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome

Dorte Glintborg, Hanne Mumm, Jens Juul Holst, and Marianne Andersen

are not aware of data in obese patients with PCOS. Increased insulin levels during OCP could be associated with increased risk of RH in PCOS, but no study tested this hypothesis. Treatment with metformin improved insulin sensitivity and ovulatory

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Effect of metformin on reducing platelet dysfunction in gestational diabetes mellitus: a randomized controlled trial

Panisa Hantrakun, Rattanaporn Sekararithi, Thidarat Jaiwongkam, Sirinart Kumfu, Chatree Chai-adisaksopha, Nipon Chattipakorn, Theera Tongsong, and Phudit Jatavan

Highlight Metformin significantly reduces fetal weight in women with GDM, theoretically preventing macrosomia. Metformin does not improve oxidative stress and platelet dysfunction in women with GDM. Introduction

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Effects and safety of metformin in patients with concurrent diabetes mellitus and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Ziting Liang, Mengge Yang, Changjuan Xu, Rong Zeng, and Liang Dong

hospitalizations and mortality ( 5 , 6 ). As a result, appropriate treatments are urgently needed for patients with concurrent DM and COPD. Metformin, a typical oral biguanide, is still the first-line therapy for DM ( 7 ). Metformin can decrease plasma glucose

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The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Zeeshan Javed, Maria Papageorgiou, Leigh A Madden, Alan S Rigby, Eric S Kilpatrick, Stephen L Atkin, and Thozhukat Sathyapalan

the EMP levels have yielded mixed results. For example, hormonal contraceptives, which are often prescribed to manage hyperandrogenism and menstrual disturbances in this population, have been shown to increase serum ICAM-1 ( 21 ). Metformin, which may