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Ashley N Reeb, Andrea Ziegler, and Reigh-Yi Lin

immunodeficient NSG ( NOD/ScidIl2rg-/- ) mice to initiate primary tumors. These cell lines were also injected into the lateral tail vein to evaluate their metastatic potential for lung colonization. Tumor progression and metastasis were evaluated by bioluminescent

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Keiko Ohkuwa, Kiminori Sugino, Mitsuji Nagahama, Wataru Kitagawa, Kenichi Matsuzu, Akifumi Suzuki, Chisato Tomoda, Kiyomi Hames, Junko Akaishi, Chie Masaki, and Koichi Ito

patients with DTC and is predominantly observed in the lungs and bone ( 3 , 4 , 5 , 6 ). When treating metastatic tumors of differentiated thyroid carcinoma, a favorable prognosis can be expected after radioactive iodine (RAI) therapy after total

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Tiina Vesterinen, Teijo Kuopio, Maarit Ahtiainen, Aija Knuuttila, Harri Mustonen, Kaisa Salmenkivi, Johanna Arola, and Caj Haglund

pulmonary neuroendocrine tumors together with high-grade large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC). However, PCs constitute a totally different entity based on a low number of genetic mutations, low metastatic potential

Open access

David T Broome, Gauri B Gadre, Ehsan Fayazzadeh, James F Bena, and Christian Nasr

their tumor ( n  = 112). The majority of patients did not have visible lung metastases on diagnosis (62.9%, n  = 90), but 37.1% of patients had developed lung metastases ( n  = 53) during follow-up ( Table 2 ). In the patients with lung metastases, a

Open access

B C M Hermans, J L Derks, H J M Groen, J A Stigt, R J van Suylen, L M Hillen, E C van den Broek, E J M Speel, and A-M C Dingemans

Introduction Neuroendocrine neoplasms can originate in various organ systems and are subdivided in neuroendocrine tumors (NET) and neuroendocrine carcinoma (NEC) ( 1 ). The most common NEC is small-cell lung carcinoma (SCLC), followed by

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Sandeep Kumar, Anurag Ranjan Lila, Saba Samad Memon, Vijaya Sarathi, Virendra A Patil, Santosh Menon, Neha Mittal, Gagan Prakash, Gaurav Malhotra, Nalini S Shah, and Tushar R Bandgar

72 and 55.2%, and median tumor size was 3.5 and 3.6 cm, respectively ( 34 , 35 ). In our collated data, the common metastatic sites for MEN2 PCC are the liver (47.8%), lungs (34.9%), bone (26.1%), and lymph node (8.3%) which is in agreement with the

Open access

Chao-bin He, Yu Zhang, Zhi-yuan Cai, and Xiao-jun Lin

surrounding organs such as liver and lung are pushed aside by these metastatic sites, making it possible to remove tumor from the surrounding liver and lung tissues and essentially enucleating them ( 5 ). Moreover, different from metastatic pancreatic

Open access

Norra Kwong, Ellen Marqusee, Michael S Gordon, P Reed Larsen, Jeffrey R Garber, Matthew I Kim, and Erik K Alexander

after decades. Metabolically active metastatic disease was defined as positive FDG uptake on PET scanning or lung radioactive iodine uptake upon radionuclide scanning consistent with metastatic disease. Permission was obtained from the BWH Institutional

Open access

M Ingenwerth, T Brandenburg, D Führer-Sakel, M Goetz, F Weber, H Dralle, H-U Schildhaus, K W Schmid, and S Theurer

Delta-like ligand 3 (DLL3), is an inhibitory NOTCH ligand, which is overexpressed in high grade neuroendocrine tumors-like small cell lung cancer (SCLC) and other tumors of neuroendocrine origin-like small cell bladder cancer and metastatic

Open access

Aida Javanbakht, Massimo D’Apuzzo, Behnam Badie, and Behrouz Salehian

first metastatic manifestation of the primary tumor in 34.5% of cases and lung cancers were the source of Pit Mets in 50% ( 11 ). Thyroid cancer is the third most common source of Pit Met. Occasionally, papillary thyroid cancer is diagnosed after finding