levels decrease with aging, and the possibility that the GHRH/GH/IGF-1 axis is involved in age-related cognitive deficits is suggested by several studies ( 2 , 3 , 4 ). Accordingly, in rodents, the age-related decline in spatial and reference memory is
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Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori, and Luigi Brunetti
Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, and Weiping Teng
memory dysfunction ( 2 , 3 , 4 , 5 ). We previously found that decreased activation of the cAMP response element-binding protein signaling pathway in pups was related to impaired cognitive function caused by maternal SCH ( 6 ). However, the
Lukas Engler, Christian Adolf, Daniel A Heinrich, Anna-Katharine Brem, Anna Riester, Anna Franke, Felix Beuschlein, Martin Reincke, Axel Steiger, and Heike Künzel
, 4 ); however, the underlying pathophysiology is not fully clarified. Animal data emphasize the importance of a balanced MR/glucocorticoid receptor (GR) system for cognitive functions ( 5 ) and support the role of MR in memory functions. Furthermore
Lin Ji, Huan-Tong Wu, Xiao-Yan Qin, and Rongfeng Lan
(BDNF) secretion from cortical neurons ( 7 ), low bone mineral density and deficits in learning and memory ( 15 ). Therefore, pathophysiological conditions observed in Cpe fat /Cpe fat mice and Cpe KO mice suggest that CPE plays a variety of roles in
Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant, and Agnès Linglart
similar to those previously reported, i.e., non-specific digestive symptoms, concentration or memory problems, exhaustion and adrenal insufficiency. One individual, who had a high plasma concentration of mitotane, developed acute severe hepatitis with
Elena V Varlamov, Dan Alexandru Niculescu, Swechya Banskota, Simona Andreea Galoiu, Catalina Poiana, and Maria Fleseriu
(35.6%), snoring (32.9%), memory loss (29.2%), frontal bossing (25%), hirsutism (25%), jaw changes (24.5%), excessive sweating (23.6%), coarse facies (21.8%), skin tags (21.3%), carpal tunnel syndrome (20.4%), round face (19.4%), back neck pain (19
Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader, and Robson Augusto Souza Santos
kidney ( 3 ). A relevant part of this new understanding is derived from the phenotypic characterization of Mas-deficient mice in a variety of models, tissues and conditions, including the cardiovascular system ( 4 ), liver ( 5 ), testis ( 6 ), memory
Elena Valassi, Iacopo Chiodini, Richard A Feelders, Cornelie D Andela, Margueritta Abou-Hanna, Sarah Idres, and Antoine Tabarin
.3 Depression/mood problems 58.8 48.1 Muscle weakness 57.8 43.4 Anxiety 54.1 39.1 Hypertension 52.5 22.2 Loss of concentration 45.0 28.4 Memory problems 41.9 30.3 Menstrual disturbances 35.6 12
Caroline Culen, Diana-Alexandra Ertl, Katharina Schubert, Lisa Bartha-Doering, and Gabriele Haeusler
involved, classification skills improve, egocentric view is over, viewpoints of others can be taken in account – Ask for achievements in school – when difficulties are reported, organize specific support – Specific risk of impairment in visual memory
Jane Fletcher, Emma L Bishop, Stephanie R Harrison, Amelia Swift, Sheldon C Cooper, Sarah K Dimeloe, Karim Raza, and Martin Hewison
actions of 1,25D during antigen presentation is to better facilitate the development of memory T cells. Inflammatory stimuli are required to activate DC to enable antigen presentation and subsequent expansion of effector T cells and the development of
