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Xuechao Jiang, Yonghui Wang, Xiaoying Li, Leqi He, Qian Yang, Wei Wang, Jun Liu and Bingbing Zha

transcription factors, splicing factors, or RNA-decay machinery ( 17 , 18 ). In this study, we aimed to identify lncRNA–mRNA pairs that play a functional role in GD. We found that patients with newly diagnosed GD had significantly higher numbers of B cells

Open access

Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer and Irvin M Modlin

, and aggressiveness e.g., non-progressive vs malignant/metastatic) ( 41 , 42 ) and have demonstrable predictive utility at a tissue level ( 43 ). More recently, blood-based assays (CTCs, miRNA and circulating mRNA) have been developed. The most

Open access

June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim and Kyu Eun Lee

expression of VDR mRNA in malignant thyroid tissues is higher than that in normal thyroid ( 2 ). They also reported correlations between VDR and other genes such as ECM1 (extracellular matrix protein-1) and TMPRSS4 (type II transmembrane serine

Open access

D A Dart, K Ashelford and W G Jiang

to the AR mRNA transcript and may be in part responsible for increased AR mRNA and protein expression in response to AR-antagonist-mediated hormone starvation. Materials and methods Cell culture LNCaP cells were maintained at 37°C, 5% CO

Open access

Neil R Chappell, Beth Zhou, Amy K Schutt, William E Gibbons and Chellakkan S Blesson

. Unlike most cells whose mRNA transcripts lasts for only a few hours ( 50 ), an oocyte transcribes mRNAs to last several days ( 50 ) from fertilization to blastulation and implantation ( 50 ). The longevity of these mRNA transcripts in this unique

Open access

Erika Urbano Lima, Ileana G S Rubio, Joaquim Custodio Da Silva, Ana Luiza Galrão, Danielle Pêssoa, Taise Cerqueira Oliveira, Fabiane Carrijo, Igor Silva Campos, Luciano Fonseca Espinheira, Luiz Jose Sampaio, Claudio Rogerio Lima, Janete Maria Cerutti and Helton Estrela Ramos

thyroid cancer and HOPXβ mRNA expression. Pt. (M/F) Age (years) Histology MF EE Invasion LN TNM staging Risk HOPXβ mRNA (AU) Capsular Vascular Perineural Metastasis T N M ATA AJCC Nontumor Tumor

Open access

Julie Smith, Jan Fahrenkrug, Henrik L Jørgensen, Christina Christoffersen and Jens P Goetze

-renal adipose tissue 23 ♀/29 ♂ 23 ♀/24 ♂ Lipids in plasma 24 ♀/30 ♂ 24 ♀/24 ♂ ZT, zeitgeber time; CT, circadian time. n , number of mice included from start. Tissue mRNA extraction Approximately 30–50 mg fat tissue was

Open access

Thiago U Pantaleão, Andrea C F Ferreira, Maria C S Santos, Álvaro S P Figueiredo, Ruy A N Louzada, Doris Rosenthal, Denise P Carvalho and Vânia M Corrêa da Costa

–1992 ( 14 ). Cerebellum, hypothalamus, cerebral cortex, hippocampus, pituitary, liver and kidney were excised after treatment, immediately frozen in liquid nitrogen, and stored at −80°C for mRNA extraction and deiodinase and H 2 O 2 generating activities

Open access

Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Kaio Fernando Vitzel, Thiago Pantaleão, Vânia Maria Corrêa da Costa and Maria Tereza Nunes

. Effects of maternal IE exposure on hypothalamus and pituitary gene expression Rat dams exposed to IE treatment presented a significant increase in the hypothalamic expression of Trh mRNA ( Fig. 2A ). Moreover, Trhr mRNA content was augmented in the

Open access

Sarah J Delforce, Eugenie R Lumbers, Celine Corbisier de Meaultsart, Yu Wang, Anthony Proietto, Geoffrey Otton, Jim Scurry, Nicole M Verrills, Rodney J Scott and Kirsty G Pringle

the PCR products were verified by agarose gel electrophoresis (data not shown). mRNA abundance was constructed using a standard curve of the calibrator sample (a term placental sample collected at elective Caesarean section), and abundance was