Emmely M de Vries
Emmely M de Vries
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Hermina C van Beeren
Hermina C van Beeren
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Albert C W A van Wijk
Albert C W A van Wijk
Department of Experimental Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Andries Kalsbeek
Andries Kalsbeek
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Johannes A Romijn
Johannes A Romijn
Department of Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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regulation, fasting changes peripheral thyroid hormone (TH) metabolism, thereby contributing to the low serum TH concentrations ( 2 , 3 , 4 ), and also to low tissue TH concentrations ( 5 ). In the liver, TH can be metabolized via different pathways
David Koeckerling
David Koeckerling
Medical Sciences Division, University of Oxford, Oxford, UK
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Jeremy W Tomlinson
Jeremy W Tomlinson
Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK
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Jeremy F Cobbold
Jeremy F Cobbold
Oxford Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK
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Why fight liver fat? What is NAFLD? Non-alcoholic fatty liver disease (NAFLD) is recognised as the most common aetiology of chronic liver disease, with an estimated global prevalence of 25.2%, and as a major cause of cirrhosis and
Leanne Hodson
Leanne Hodson
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK
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Fredrik Karpe
Fredrik Karpe
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK
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Introduction The liver is a key metabolic organ that performs a multitude of physiological processes, including the regulation of systemic lipid and glucose metabolism. It provides metabolic flexibility where, over the course of a day
Christin Krause
Christin Krause
Epigenetics & Metabolism, Medical Department I, University of Lübeck, Lübeck, Germany
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Martina Grohs
Martina Grohs
Epigenetics & Metabolism, Medical Department I, University of Lübeck, Lübeck, Germany
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Alexander T El Gammal
Alexander T El Gammal
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Stefan Wolter
Stefan Wolter
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Hendrik Lehnert
Hendrik Lehnert
Medical Department I, University of Lübeck, Lübeck, Germany
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Oliver Mann
Oliver Mann
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Jens Mittag
Jens Mittag
Molecular Endocrinology, Medical Department I, University of Lübeck, Lübeck, Germany
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Henriette Kirchner
Henriette Kirchner
Epigenetics & Metabolism, Medical Department I, University of Lübeck, Lübeck, Germany
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Introduction Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in Western countries, affecting for instance more than 10% of all adults in the United States. NAFLD encompasses a wide spectrum of different stages
Sandra Pereira
Sandra Pereira
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Jessy Moore
Jessy Moore
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Jia-Xu Li
Jia-Xu Li
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Wen Qin Yu
Wen Qin Yu
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Husam Ghanim
Husam Ghanim
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Filip Vlavcheski
Filip Vlavcheski
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Yemisi Deborah Joseph
Yemisi Deborah Joseph
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Paresh Dandona
Paresh Dandona
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Allen Volchuk
Allen Volchuk
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Carolyn L Cummins
Carolyn L Cummins
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Evangelia Tsiani
Evangelia Tsiani
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Adria Giacca
Adria Giacca
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Introduction Obesity is characterized by elevated circulating free fatty acids (FFAs) that cause insulin resistance in the liver and periphery ( 1 , 2 ). FFAs induce endoplasmic reticulum (ER) stress, which occurs when misfolded or unfolded
Bledar Daka
Bledar Daka
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Thord Rosen
Thord Rosen
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Per Anders Jansson
Per Anders Jansson
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Lennart Råstam
Lennart Råstam
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Charlotte A Larsson
Charlotte A Larsson
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Ulf Lindblad
Ulf Lindblad
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Introduction Sex hormone-binding globulin (SHBG) is a circulating plasma globulin binding sex hormones, both oestradiol and testosterone and is produced primarily by the liver. In two recent studies, SHBG could predict type 2 diabetes (T2D) in
Robert Maidstone
Robert Maidstone
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Martin K Rutter
Martin K Rutter
Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK
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Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK
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Thomas Marjot
Thomas Marjot
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK
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Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK
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David W Ray
David W Ray
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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Matthew Baxter
Matthew Baxter
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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Introduction Life in advanced societies is a challenge to evolutionarily conserved mechanisms regulating rhythmic human behaviour. In preindustrial societies sunlight exposure dominates organisation of activity, feeding, and fasting. The liver
Aneta Gawlik
Aneta Gawlik
Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Michael Shmoish
Michael Shmoish
Bioinformatics Knowledge Unit, Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion – Israel Institute of Technology, Haifa, Israel
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Michaela F Hartmann
Michaela F Hartmann
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Stefan A Wudy
Stefan A Wudy
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Zbigniew Olczak
Zbigniew Olczak
Department of Diagnostic Imaging, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Katarzyna Gruszczynska
Katarzyna Gruszczynska
Department of Diagnostic Imaging, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Ze’ev Hochberg
Ze’ev Hochberg
Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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Introduction Nonsyndromic childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), a spectrum of conditions, ranging from steatosis to nonalcoholic steatohepatitis (NASH), and various degrees of fibrosis and cirrhosis ( 1
Magaly Zappa
Magaly Zappa
Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France
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INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France
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Olivia Hentic
Olivia Hentic
Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France
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Marie-Pierre Vullierme
Marie-Pierre Vullierme
Department of Radiology, AP-HP, Clichy, France
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Matthieu Lagadec
Matthieu Lagadec
Department of Radiology, AP-HP, Clichy, France
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Maxime Ronot
Maxime Ronot
Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France
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INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France
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Philippe Ruszniewski
Philippe Ruszniewski
Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France
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INSERM, UMR1149 CRI, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France
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Valérie Vilgrain
Valérie Vilgrain
Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France
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INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France
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grouped as gastroenteropancreatic neuroendocrine tumours, or GEP-NETs. They are frequently metastasised at diagnosis, and the liver is the most common site of metastases ( 1 ). The presence of liver metastases is a significant negative prognostic factor
María L Bacigalupo
María L Bacigalupo
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Verónica G Piazza
Verónica G Piazza
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Nadia S Cicconi
Nadia S Cicconi
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Pablo Carabias
Pablo Carabias
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Andrzej Bartke
Andrzej Bartke
Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA
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Yimin Fang
Yimin Fang
Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA
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Ana I Sotelo
Ana I Sotelo
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Gabriel A Rabinovich
Gabriel A Rabinovich
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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María F Troncoso
María F Troncoso
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Johanna G Miquet
Johanna G Miquet
Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina
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Introduction Liver cancer is the third most common cause of cancer-related deaths worldwide ( 1 ). Hepatocellular carcinoma (HCC) accounts for 90% of liver tumors and it is strongly associated with chronic hepatitis B or C virus infection
