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(CHD) and kidney disease in diabetes ( 13 , 14 ). Besides, lipocalin-2, a well-recognized biomarker of inflammation, infection, as well as kidney damage, may accelerate the development of diabetes by promoting IR and inflammation ( 15 ). However
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inflammatory cascades have been demonstrated to be implicated in the development and progression of DPN ( 3 ). However, the precise mechanisms underlying the development and progression of DPN remain elusive. Lipocalin 2 (LCN2), also known as 24p3 or
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complications in China . Diabetologia 2018 61 1249 – 1260 . ( https://doi.org/10.1007/s00125-018-4557-7 ) 3 Hosny SS Bekhet MM Hebah HA Mohamed NR . Urinary neutrophil gelatinase-associated lipocalin in type 2 diabetes: relation to nephropathy
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inflammation and oxidative stress Expression of the proinflammatory cytokine interleukin 18 ( Il18 ) was 3.5-fold downregulated by FGF21, but not by chow, whereas another biomarker of inflammation, lipocalin 2 ( Lcn2 ), was about five-fold downregulated by
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.3 ( 2 ), which is consistent with the susceptible sites for metabolic syndrome (MS). It has a wide range of physiological functions such as regulating blood glucose and lipid metabolism and inhibiting tissue calcification ( 3 , 4 , 5 ). Previous
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