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speculated that the increase of Hcy was at least partially due to the decrease of renal function ( 15 ), because of the evidence that Hcy was negatively correlated with kidney function in general population ( 16 , 17 , 18 ). However, it is unknown whether
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Introduction Chronic kidney disease (CKD) is a highly prevalent condition ( 1 ) and is often characterized by a decline in kidney function over time. Generally, a higher prevalence of CKD is found in women, while men with CKD have a higher
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Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
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Department of Renal Medicine, St George Hospital, Sydney, NSW, Australia
Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia
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effective means to protect kidney function in patients with T2D. Although SGLT2 inhibitors achieve urinary glucose wasting and were initially developed as glucose-lowering agents for the treatment of T2D, this represents only one of their potential
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Department of Internal Medicine, HagaHospital, The Hague, The Netherlands
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Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
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function to a lower estimated glomerular filtration rate (eGFR) and increased prevalence of CKD ( 10 , 11 , 12 ). Longitudinal studies have presented conflicting results, linking kidney function decline to low ( 13 ) or high thyroid function ( 14
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Department of Health Sciences, Department of Epidemiology and Biostatistics, Department of Public Health, Department of General Practice, Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Department of Internal Medicine, Faculty of Earth and Life Sciences, EMGO Institute for Health and Care Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
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(skeletal and in) cardiac muscle (2, 3) , indicating a potential functional role in myocardial function. Thereby, a disturbed vitamin D–PTH–calcium axis – which includes calcitriol the active form of vitamin D that is produced in the kidney – may play a
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’s pathological progression to death. Meanwhile, its fibrosis degree affects renal function ( 1 , 2 ). Silent information regulator factor 2-related enzyme 1 (Sirt1), as a key factor in regulating energy metabolism, exerts a nephroprotective effect by mediating
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.1097/00041552-199607000-00008 ) 2 Evenepoel P Claes K Kuypers D Maes B Bammens B Vanrenterghem Y . Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study . Nephrology, Dialysis, Transplantation 2004 19 1281
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany
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Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany
German Center for Diabetes Research (DZD), München-Neuherberg, Germany
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Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
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Chair of Epidemiology at UNIKAT Augsburg, Ludwig-Maximilians-Universität München, Munich, Germany
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KORA Study Center, University Hospital Augsburg, Augsburg, Germany
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Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
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Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
Deutsches Herzzentrum München, Technische Universität München, Munich, Germany
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Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
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Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
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Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany
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clinical diagnosis, since obesity and other components of the metabolic syndrome, such as elevated fasting glucose and elevated blood pressure, are associated with glomerular hyperfiltration. The currently available kidney function markers (creatinine
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Vascular Research Group, School of Community Based Medicine, Centre for Integrated Genomic Medical Research, Cardiovascular Research Group, Endocrinology and Diabetes, Salford R&D, Department of Endocrinology and Diabetes, Faculty of Medical, Human and Life Sciences, The University of Manchester, Manchester M13 9PT, UK
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Vascular Research Group, School of Community Based Medicine, Centre for Integrated Genomic Medical Research, Cardiovascular Research Group, Endocrinology and Diabetes, Salford R&D, Department of Endocrinology and Diabetes, Faculty of Medical, Human and Life Sciences, The University of Manchester, Manchester M13 9PT, UK
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IGFBP2 is a marker for deterioration in renal function in Caucasians with type 2 diabetes. The cellular activities of IGFBP2 in the kidney may have significant implications in diabetic nephropathy and research is required to elucidate whether there is a
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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Endocrinology and Metabolism 2001 86 5301 – 5306 . ( https://doi.org/10.1210/jcem.86.11.8059 ) 23 Levey AS Eckardt KU Dorman NM Christiansen SL Cheung M Jadoul M Winkelmayer WC . Nomenclature for kidney function and disease-executive summary and