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L Bahler, H J Verberne, E Brakema, R Tepaske, J Booij, J B Hoekstra and F Holleman

study was to gain a better understanding of the mechanism of action of bromocriptine on insulin sensitivity. First, we aimed to investigate whether bromocriptine administration for 2 weeks had a different effect on insulin sensitivity in lean compared

Open access

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Magdalena Stefanowicz, Natalia Matulewicz, Irina Kowalska and Marek Strączkowski

. As chemerin is related to the sequelae of insulin resistance, the association between chemerin and insulin sensitivity seems to be of importance. However, studies regarding this relationship are inconsistent. Significant positive correlation between

Open access

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz and Marek Strączkowski

ATGL. Upon hormonal stimulation, PLIN is phosphorylated, and ABHD5 is dissociated from PLIN and may interact with ATGL promoting its activation ( 4 ). The inter-relationships between AT lipolysis and insulin sensitivity are complex and still not fully

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Anna Kistner, Mireille Vanpée and Kerstin Hall

development. Our hypothesis is that leptin may enhance hepatic insulin sensitivity and exert a protective property. Materials and methods Subjects The characterizations and the modes of selection for the children (7) and the adult women (23

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Tao Yuan, Lanping Jiang, Chen Chen, Xiaoyan Peng, Min Nie, Xuemei Li, Xiaoping Xing, Xuewang Li and Limeng Chen

600968) of the distal convoluted tubule (DCT) ( 2 ). Recently ( 3 ), impaired glucose metabolism and insulin sensitivity were reported in GS patients, but insulin secretion function has not been studied in this population. Due to the lack of research in

Open access

Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, John Vissing, Morten Frost, Knud Bonnet Yderstræde and Per Heden Andersen

glucose intolerance were studied with both OGTT and hyperinsulinemic clamp. In these patients, both decreased insulin sensitivity and impaired β-cell function was demonstrated prior to development of overt diabetes ( 20 ). Insulin sensitivity was equally

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Esben Thyssen Vestergaard, Morten B Krag, Morten M Poulsen, Steen B Pedersen, Niels Moller, Jens Otto Lunde Jorgensen and Niels Jessen

sensitivity (17) . A correlation between insulin sensitivity and serum concentrations of RBP4 has, however, not been consistently reported (18) , and a number of reports have questioned the role of RBP4 in insulin resistance (19) . The aim of the present

Open access

Giorgio Bedogni, Andrea Mari, Alessandra De Col, Sofia Tamini, Amalia Gastaldelli and Alessandro Sartorio

metabolism deteriorates more rapidly than in adults but with similar mechanisms ( 1 ). The RISC (Relationship between Insulin Sensitivity and Cardiovascular risk) study has recently evaluated the association between serum lipids and β-cell function under

Open access

Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo and Carla Giordano

). Blood samples were collected every 30 min for 2 h for glucose and insulin measurements. As surrogate estimates of insulin sensitivity we considered the homeostasis model assessment estimate of insulin resistance (Homa-IR) ( 19 ) and the insulin

Open access

C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby and M D Robertson

fiber and has been shown to have beneficial effects on insulin sensitivity and fatty acid (FA) metabolism in both healthy individuals and those with metabolic syndrome (3, 4, 5, 6, 7) . However, the efficacy of RS in individuals with T2DM has not been