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Tristan Avril Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France

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Quentin Hennocq Datascience platform, Imagine Institute, Université Paris Cité, Paris, France

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Anne-Sophie Lambert Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France

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Juliane Leger Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France
Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France

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Dominique Simon Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France

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Laetitia Martinerie Pediatric Endocrinology Department, CHU Robert Debré, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR de la Croissance et du Développement, Paris, France
Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France
Inserm UMR1185, Le Kremlin Bicetre, Paris, France

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Claire Bouvattier Pediatric Endocrinology Department, CHU Bicetre, Assistance Publique-Hôpitaux de Paris, Reference Center for Rare Disease CRMR DevGen, Le Kremlin Bicêtre, Paris, France
Inserm UMR1185, Le Kremlin Bicetre, Paris, France
Paris-Saclay University, Paris, France

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modalities of gonadotropins administration in two groups of CHH boys, treated during the mini-pubertal period. Multi-weekly injections of recombinant human chorionic gonadotrophin (hCG) and FSH for 3 months was the first modality (injection group). Continuous

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0252
Volume/Issue:
Volume 12: Issue 4
Open access
Nandini Shankara Narayana Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Lam P Ly Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Veena Jayadev Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Carolyn Fennell Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Sasha Savkovic Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Ann J Conway Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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David J Handelsman Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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most common route of administration has been the parenteral injection of testosterone as a pro-drug esterified to short-chain aliphatic fatty acids in a vegetable oil vehicle ( 2 ). These injectable products are affordable with depot effects that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0109
Volume/Issue:
Volume 10: Issue 7
Open access
Eric M Ndombi Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Valentine Budambula Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Mark K Webale Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Francis O Musumba Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Jesca O Wesongah Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Erick Mibei Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Aabid A Ahmed
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Raphael Lihana Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Tom Were Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya

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Introduction Injection drug use and associated co-morbidities are an increasing public health burden in the world (1) . An estimated 15.9 million people worldwide are injection drug users (IDUs), comprising 3 and 10 million HIV and hepatitis C

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0071
Volume/Issue:
Volume 4: Issue 4
Open access
Cecilia Follin Department of Endocrinology, Skåne University Hospital, Lund, Sweden

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Sven Karlsson Department of Endocrinology, Skåne University Hospital, Lund, Sweden

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( 9 ). In patients with acromegaly, impaired quality of life (QoL) – as assessed by specific questionnaires – has been reported even in patients who experience long-term cure ( 10 ). The chronic need for monthly injections of SSA might negatively

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0038
Volume/Issue:
Volume 5: Issue 4
Open access
Régis Coutant Department of Pediatric Endocrinology and Diabetology, Reference Center for Rare Pituiatry Diseases, University Hospital of Angers, Angers, France

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Maithé Tauber Reference Center for the Prader-Willi syndrome and other rare obesities with feeding disorders (PRADORT), Children Hospital, CHU Toulouse, Toulouse, France
Pediatric team of the Clinical Investigation Center 9302/INSERM, Hospital of Children, Toulouse, France
Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), INSERM UMR1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France

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Béatrice Demaret GRANDIR - French Growth Disorders Association, Asnières-sur-Seine, France

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Robin Henocque Pfizer France, Paris France

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Yves Brault Pfizer France, Paris France

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François Montestruc eXYSTAT, Malakoff, France

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Olivier Chassany Health Economics Clinical Trial Unit (URC-ECO), Hospital of Hotel-Dieu, AP-HP, Paris, France
Patient-Reported Outcomes Unit (PROQOL), UMR 1123, University Paris Cité, INSERM, Paris, France

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Michel Polak Hôpital Universitaire Necker Enfants Malades, Pediatric Endocrinology, Gynecology and Diabetology, Imagine Institute, INSERM U1163, Cochin Institute, INSERM U1016, Centre de référence des pathologies endocriniennes rares de la croissance et du développement, Université de Paris Cité, Paris, France

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the QOLITHOR Study Group
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the QOLITHOR Study Group

improvement of psychosocial problems ( 3 , 4 ) and improvement in quality of life (QOL) ( 5 , 6 ). In addition, rhGH injections are well tolerated ( 7 , 8 ) even if adherence to treatment was shown as suboptimal ( 9 ). The majority of currently available

Article Type:
Research Article
Collections:
Paediatric Endocrinology
DOI:
https://doi.org/10.1530/EC-22-0464
Volume/Issue:
Volume 12: Issue 4
Open access
Ashley N Reeb Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Andrea Ziegler Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Reigh-Yi Lin Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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microenvironment. Previously, we and other laboratories developed an orthotopic thyroid cancer model that faithfully recapitulates the clinical characteristics of advanced thyroid cancer ( 1 , 2 , 3 , 4 ). In addition, tail vein or intracardiac injection models

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0114
Volume/Issue:
Volume 5: Issue 2
Open access
Esben S Lauritzen The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark

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Nikolaj Rittig The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark

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Ermina Bach The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark

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Niels Møller The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark

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Mette Bjerre The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark

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), healthy and without regular intake of medicine were investigated two times: (1) After isotonic saline injection (bolus saline) and (2) after an Escherichia coli endotoxin (10,000 USP Endotoxin, lot H0K354; The United States Pharmacopeial Convention, Inc

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0103
Volume/Issue:
Volume 6: Issue 1
Open access
Myrtille Fouché Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Yves Bouffard Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Mary-Charlotte Le Goff Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Johanne Prothet Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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François Malavieille Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Pierre Sagnard Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Françoise Christin Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Davy Hayi-Slayman Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Arnaud Pasquer Department of Visceral Surgery, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Gilles Poncet Department of Visceral Surgery, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Thomas Walter Department of Hepatogastroenterology and Oncology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Thomas Rimmelé Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France
EA 7426 Hospices Civils de Lyon-University Claude Bernard Lyon 1-Biomérieux ‘Pathophysiology of Injury-Induced Immunosuppression’ Pi3, Lyon, France

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(HR) or blood pressure (BP)) ≥40%, not explained by surgical or anaesthetic management and regressive ≥20% within 5 min after the octreotide bolus injection; probable ioCS was defined as cases for which manifestations did not meet all criteria of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0324
Volume/Issue:
Volume 7: Issue 12
Open access
Fahim Ebrahimi Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Basel Hospital, Basel, Switzerland
Department of Clinical Research, University of Basel Hospital, Basel, Switzerland

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Sandrine A Urwyler Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Basel Hospital, Basel, Switzerland
Department of Clinical Research, University of Basel Hospital, Basel, Switzerland

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Philipp Schuetz Department of Clinical Research, University of Basel Hospital, Basel, Switzerland
Division of Endocrinology, Diabetes and Metabolism, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland

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Beat Mueller Department of Clinical Research, University of Basel Hospital, Basel, Switzerland
Division of Endocrinology, Diabetes and Metabolism, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland

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Luca Bernasconi Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland

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Peter Neyer Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland

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Marc Y Donath Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Basel Hospital, Basel, Switzerland
Department of Clinical Research, University of Basel Hospital, Basel, Switzerland

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Mirjam Christ-Crain Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Basel Hospital, Basel, Switzerland
Department of Clinical Research, University of Basel Hospital, Basel, Switzerland

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anakinra, purchased by Swedish Orphan Biovitrum, or an identically appearing placebo twice-daily, as self-administered, subcutaneous injections for 4 weeks. Compliance to treatment was assessed by counting returned empty syringes, by keeping a medication

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0201
Volume/Issue:
Volume 8: Issue 6
Open access
Milou Cecilia Madsen Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands

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Martin den Heijer Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands

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Claudia Pees Walaeus Library, Leiden University Medical Center, Leiden, the Netherlands

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Nienke R Biermasz Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Leontine E H Bakker Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands

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-acting intramuscular injections, such as Sustanon®, are esters of testosterone (TE) that have been used for many years for the treatment of testosterone deficiency prior to the availability of transdermal testosterone preparations. However, they have to be administered

Article Type:
Review Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0112
Volume/Issue:
Volume 11: Issue 8
Open access