Xiaobing Lu
Xiaobing Lu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Jiang Yue
Jiang Yue
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Qianjing Liu
Qianjing Liu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Shengyun He
Shengyun He
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Ying Dong
Ying Dong
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Ming Zhang
Ming Zhang
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Yicheng Qi
Yicheng Qi
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Minglan Yang
Minglan Yang
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Wang Zhang
Wang Zhang
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Hua Xu
Hua Xu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Qing Lu
Qing Lu
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Jing Ma
Jing Ma
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Diagnostics). According to the World Health Organization (WHO) OGTT definition ( 26 ), subjects were classified as normal (fasting plasma glucose (FPG) <5.6 mmol/L) and impaired glucose metabolism either with established T2DM (FPG ≥7.0 and/or 2-h postprandial
Wenqi Yang
Wenqi Yang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Ling Liu
Ling Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yuan Wei
Yuan Wei
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Chunlu Fang
Chunlu Fang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Fu Zhou
Fu Zhou
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Jinbao Chen
Jinbao Chen
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qinghua Han
Qinghua Han
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Meifang Huang
Meifang Huang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xuan Tan
Xuan Tan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiuyue Liu
Qiuyue Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiang Pan
Qiang Pan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Lu Zhang
Lu Zhang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xiaojuan Lei
Xiaojuan Lei
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Liangming Li
Liangming Li
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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present study was to investigate whether exercise could alleviate the FGF21–adiponectin axis impairment and ameliorate glucose metabolism and insulin resistance in diet-induced obese mice. Materials and methods Animals and diet Eight
Selina Mäkinen
Selina Mäkinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Neeta Datta
Neeta Datta
Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Yen H Nguyen
Yen H Nguyen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Petro Kyrylenko
Petro Kyrylenko
Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Markku Laakso
Markku Laakso
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland
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Heikki A Koistinen
Heikki A Koistinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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, 19 ). Lactone-form statins have been observed to be more prone to cause myotoxic effects ( 19 ), and thus may contribute to impairments in glucose metabolism. Glucose uptake was inhibited with lactone-form simvastatin in rat L6 myotubes via inhibition
Jakob Høgild Langdahl
Jakob Høgild Langdahl
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Endocrinology, Hospital of Southwest Jutland, Esbjerg, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Endocrinology, Hospital of Southwest Jutland, Esbjerg, Denmark
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Anja Lisbeth Frederiksen
Anja Lisbeth Frederiksen
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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John Vissing
John Vissing
Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Copenhagen, Denmark
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Morten Frost
Morten Frost
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
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Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
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Knud Bonnet Yderstræde
Knud Bonnet Yderstræde
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
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Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
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Per Heden Andersen
Per Heden Andersen
Department of Endocrinology, Hospital of Southwest Jutland, Esbjerg, Denmark
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muscle is inversely correlated to age of diabetes debut ( 14 ). It is debated whether the impaired glucose metabolism in m.3243A>G carriers is characterized by insulin resistance, insulin secretion defect or a combination. The nuclear gene encoded
Tao Yuan
Tao Yuan
Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Lanping Jiang
Lanping Jiang
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Chen Chen
Chen Chen
Department of Pediatrics, State Key Laboratory of Medical Genetics, Xiangya Hospital, Central South University, Changsha, China
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Xiaoyan Peng
Xiaoyan Peng
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Min Nie
Min Nie
Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xuemei Li
Xuemei Li
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xiaoping Xing
Xiaoping Xing
Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xuewang Li
Xuewang Li
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Limeng Chen
Limeng Chen
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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600968) of the distal convoluted tubule (DCT) ( 2 ). Recently ( 3 ), impaired glucose metabolism and insulin sensitivity were reported in GS patients, but insulin secretion function has not been studied in this population. Due to the lack of research in
Tingting Shu
Tingting Shu
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Zhigang Lv
Zhigang Lv
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Yuchun Xie
Yuchun Xie
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Junming Tang
Junming Tang
Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China
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Xuhua Mao
Xuhua Mao
Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China
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excessive ROS production inducing oxidative stress. Abnormal iron metabolism in the mitochondria eventually impaired insulin secretion as Fig. 6 showed. Relieved iron overload status had a positive effect on the blood glucose control in the early onset of
A V Dreval
A V Dreval
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I V Trigolosova
I V Trigolosova
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I V Misnikova
I V Misnikova
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Y A Kovalyova
Y A Kovalyova
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R S Tishenina
R S Tishenina
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I A Barsukov
I A Barsukov
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A V Vinogradova
A V Vinogradova
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B H R Wolffenbuttel
B H R Wolffenbuttel
Moscow Regional Scientific Research Clinical Institute, Department of Endocrinology, 61/2 Shepkina str., 129110 Moscow, Russia
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BMI. SBP, systolic blood pressure; DBP, diastolic blood pressure; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; ECMDs, early carbohydrate metabolism disorders. Table 2 Comparative characteristics and results of the oral glucose
Leanne Hodson
Leanne Hodson
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK
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Fredrik Karpe
Fredrik Karpe
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK
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impaired insulin-dependent regulation of glucose and hepatic lipid metabolism ( 3 ). Hyperinsulinaemia is a common finding in obesity, and may be the result of insulin hypersecretion and/or impaired hepatic insulin extraction; individuals with
Olli Helminen
Olli Helminen
Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University, Hospital and University of Oulu, Oulu, Finland
Surgery Research Unit, Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
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Surgery Research Unit, Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
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Tytti Pokka
Tytti Pokka
Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University, Hospital and University of Oulu, Oulu, Finland
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Susanna Aspholm
Susanna Aspholm
Tampere Centre for Child Health Research, Tampere University Hospital, Tampere, Finland
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Jorma Ilonen
Jorma Ilonen
Immunogenetics Laboratory, University of Turku, Turku, Finland
Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
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Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
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Olli G Simell
Olli G Simell
Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
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Mikael Knip
Mikael Knip
Tampere Centre for Child Health Research, Tampere University Hospital, Tampere, Finland
Pediatric Research Center, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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Pediatric Research Center, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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Riitta Veijola
Riitta Veijola
Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University, Hospital and University of Oulu, Oulu, Finland
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factor with a risk of 70% for clinical diabetes over the subsequent 10 years ( 6 ). Abnormalities in the glucose metabolism appear approximately 2 years before the clinical presentation ( 7 ). Metabolic parameters assessed based on HbA1c ( 8 ), oral
Peter Wolf
Peter Wolf
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Alexandre Dormoy
Alexandre Dormoy
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Luigi Maione
Luigi Maione
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Sylvie Salenave
Sylvie Salenave
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Jacques Young
Jacques Young
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Peter Kamenický
Peter Kamenický
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Philippe Chanson
Philippe Chanson
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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mortality, mainly because of cardio-metabolic complications ( 1 , 2 , 3 ). Impaired glucose metabolism is frequently observed in acromegaly. It is mainly caused by the insulin-antagonizing effects of GH-inducing hepatic and peripheral insulin resistance
