Introduction Idiopathic hypogonadotropic hypogonadism (IHH) is also known as congenital hypogonadotropic hypogonadism. This rare clinically and genetically heterogeneous disorder is characterized by complete or partial pubertal failure, which
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Clinical characteristics of 138 Chinese female patients with idiopathic hypogonadotropic hypogonadism
Rui-yi Tang, Rong Chen, Miao Ma, Shou-qing Lin, Yi-wen Zhang, and Ya-ping Wang
Clinical characteristics and genetic expansion of 46,XY disorders of sex development children in a Chinese prospective study
Yijun Tang, Yao Chen, Jiayi Wang, Qianwen Zhang, Yirou Wang, Yufei Xu, Xin Li, Jian Wang, and Xiumin Wang
.3109/09513590.2012.752459 ) 48 Topaloğlu AK . Update on the genetics of idiopathic hypogonadotropic hypogonadism . Journal of Clinical Research in Pediatric Endocrinology 2017 9 ( Supplement 2 ) 113 – 122 . ( https://doi.org/10.4274/jcrpe.2017.S010 ) 49 Li L Gao F Fan
Mutation spectrum and frequency of copy number variations of the ANOS1 gene in patients with Kallmann syndrome or normosmic isolated hypogonadotropic hypogonadism
Ja Hye Kim, Yunha Choi, Soojin Hwang, Ji-Hee Yoon, Jieun Lee, Min Jae Kang, Gu-Hwan Kim, Han-Wook Yoo, and Jin-Ho Choi
panel sequencing for molecular diagnosis of Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism . Experimental and Clinical Endocrinology and Diabetes 2019 127 538 – 544 . ( https://doi.org/10.1055/a-0681-6608 ) 7 Amato LGL
Functional hypogonadism in adolescence: an overlooked cause of secondary hypogonadism
Rebeca Esquivel-Zuniga and Alan D Rogol
other neuroendocrine deficiencies or be isolated (isolated hypogonadotropic hypogonadism, IHH) or lastly idiopathic; and (3) functional hypogonadotropic hypogonadism (FHH), characterized by low levels of FSH and LH, but which represents a transient
Phenotypic spectrum of patients with mutations in CHD7: clinical implications of endocrinological findings
Ja Hye Kim, Yunha Choi, Soojin Hwang, Gu-Hwan Kim, Han-Wook Yoo, and Jin-Ho Choi
-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome . American Journal of Human Genetics 2008 83 511 – 519 . ( https://doi.org/10.1016/j.ajhg.2008.09.005 ) 18834967 10.1016/j.ajhg.2008.09.005 5 Shin SJ Sul Y Kim JH Cho
Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism
Mikkel Andreassen, Anders Juul, Ulla Feldt-Rasmussen, and Niels Jørgensen
Liu Z Zhen J Nie M Min L Wu X. Congenital combined pituitary hormone deficiency patients have better responses to gonadotrophin-induced spermatogenesis than idiopathic hypogonadotropic hypogonadism patients . Human Reproduction 2015 30 2031
GNRHR biallelic and digenic mutations in patients with normosmic congenital hypogonadotropic hypogonadism
Catarina I Gonçalves, José M Aragüés, Margarida Bastos, Luísa Barros, Nuno Vicente, Davide Carvalho, and Manuel C Lemos
– 28 . ( doi:10.1016/j.mce.2011.04.018 ) 6 Bianco SD Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism . Nature Reviews Endocrinology 2009 5 569 – 576 . ( doi:10.1038/nrendo.2009.177 ) 7 Lemos
Gonadotropin administration to mimic mini-puberty in hypogonadotropic males: pump or injections?
Tristan Avril, Quentin Hennocq, Anne-Sophie Lambert, Juliane Leger, Dominique Simon, Laetitia Martinerie, and Claire Bouvattier
, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism . Journal of Clinical Endocrinology and Metabolism 2002 87 152 – 160 . ( https://doi.org/10.1210/jcem.87.1.8131 ) 7 Sarfati J Bouvattier C Bry
Beyond hormone replacement: quality of life in women with congenital hypogonadotropic hypogonadism
Shota Dzemaili, Jitske Tiemensma, Richard Quinton, Nelly Pitteloud, Diane Morin, and Andrew A Dwyer
: reversible hypogonadotropic hypogonadism . European Journal of Endocrinology 2016 174 R267 – R274 . ( doi:10.1530/EJE-15-1033 ) 7 Seminara SB Hayes FJ Crowley WF Jr. Gonadotropin-releasing hormone deficiency in the human (idiopathic
Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy
Nathalie Ly, Sophie Dubreuil, and Philippe Touraine
deficiency (GHD) without GHRT ( 9 , 10 , 11 , 12 ). However, spontaneous pregnancies are scarce, as hypogonadotropic hypogonadism is frequently concomitant with GHD. Vila et al. report the largest international cohort of 8152 women with GHD, who received
