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Benjamin G Challis, Andrew S Powlson, Ruth T Casey, Carla Pearson, Brian Y Lam, Marcella Ma, Deborah Pitfield, Giles S H Yeo, Edmund Godfrey, Heok K Cheow, V Krishna Chatterjee, Nicholas R Carroll, Ashley Shaw, John R Buscombe and Helen L Simpson

Introduction Hyperinsulinaemic hypoglycaemia (HH) is uncommon in otherwise healthy adults due to the existence of robust counter-regulatory homeostatic mechanisms that defend against falling blood glucose concentrations. A clinical diagnosis

Open access

Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel and André P van Beek

accompanied by long-term complications such as postprandial hyperinsulinaemic hypoglycaemia (PHH) ( 2 , 3 ). PHH typically occurs 1–3 h after a meal and can lead to autonomic and neuroglycopenic symptoms such as sweating, palpitations, hunger and drowsiness

Open access

Peter L Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, Valeriya Lyssenko, Leif Groop, Jens J Holst, Allan A Vaag and Birger Thorsteinsson

Introduction Patients with type 1 diabetes are at daily risk of events of severe hypoglycaemia ( 1 , 2 , 3 , 4 , 5 , 6 , 7 ). The distribution of these events is much skewed with a minority of subjects accounting for the vast majority of

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Xiaolei Hu and Fengling Chen

human insulin analogues ( 1 ), especially in Asian populations ( 6 , 7 , 8 , 9 , 10 , 11 , 12 ). Different from insulin autoimmune syndrome (IAS, also called Hirata disease), which is a condition characterized by spontaneous hypoglycaemia and is

Open access

Dorte Glintborg, Hanne Mumm, Jens Juul Holst and Marianne Andersen

in insulin resistant states such as obesity and type 2 diabetes ( 3 ), whereas results in patients with PCOS are conflicting ( 4 , 5 , 6 ). Reactive hypoglycaemia (RH) is defined as a drop in blood glucose levels 1½–5 h after food consumption

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

neuropathy ( 3 ). However, adverse events, such as severe hypoglycaemia and weight gain, are also strongly associated with long-term administration of insulin ( 4 ). To overcome this shortcoming, the development of new therapy agents is urgently needed

Open access

Richard H Tuligenga

been inconclusive (12) . Recent randomised controlled trials (RCTs) show that intensive glycaemic control does not have beneficial effects on the rate of cognitive decline (13, 14, 15, 16) . The increased frequency of hypoglycaemia in patients treated

Open access

Amalie R Lanng, Lærke S Gasbjerg, Natasha C Bergmann, Sigrid Bergmann, Mads M Helsted, Matthew P Gillum, Bolette Hartmann, Jens J Holst, Tina Vilsbøll and Filip K Knop

glucose metabolism ( 2 ). It is well known that acute alcohol ingestion increases the risk of hypoglycaemia; most likely due to inhibitory effects of alcohol on hepatic gluconeogenesis ( 3 ). In addition, it is well known that chronic alcohol consumption

Open access

Marko Stojanovic, Zida Wu, Craig E Stiles, Dragana Miljic, Ivan Soldatovic, Sandra Pekic, Mirjana Doknic, Milan Petakov, Vera Popovic, Christian Strasburger and Márta Korbonits

0.1 ng/mL range. Baseline serum AIP was independent of age, gender or BMI. Serum AIP levels in all investigated groups were stable over time in samples taken at 30-min intervals over 2-h course and were unchanged by severe hypoglycaemia (induced by

Open access

Aldo Bonaventura, Fabrizio Montecucco and Franco Dallegri

measures recommended to limit iatrogenic hypoglycaemia are summarized in Fig. 1 . Figure 1 Measures to limit iatrogenic hypoglycemia. The first step is to limit the hypoglycemic episodes, since this approach can completely restore hypoglycemia awareness in