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I Azzam, S Gilad, R Limor, N Stern, and Y Greenman

hydrocortisone injection (phase 4) ( Fig. 1A , P  = 0.008; and P  = 0.02, P  = 0.01 and P  = 0.01 for the comparison among phase 1 vs 4, 2 vs 4 and 3 vs 4, respectively). Similarly, the expected and concordant changes occurred in plasma ACTH levels, with a

Open access

Stephanie Burger-Stritt, Linda Bachmann, Max Kurlbaum, and Stefanie Hahner

intramuscular (i.m.) hydrocortisone (HC) self-injection ( 18 ). Furthermore, off-label use of subcutaneous (s.c.) administration of HC appears to be a safe and efficient alternative ( 19 ). However, an easy to handle GC emergency set, for example, a ‘ready

Open access

Wiebke Arlt and the Society for Endocrinology Clinical Committee

.v. injection of 250 micrograms ACTH 1–24 ); however, if the patient is severely ill, confirmation of diagnosis can be safely left until after clinical recovery following implementation of emergency dose hydrocortisone treatment Serum/plasma aldosterone and

Open access

Salem A Beshyah, Khawla F Ali, and Hussein F Saadi

preparation do you, most commonly, use for replacement therapy? (Hydrocortisone, Cortisone acetate, Prednisone/Prednisolone, Long-acting prednisolone, Dexamethasone).  4. How do you usually divide the daily dose of glucocorticoids used for replacement

Open access

Anastasia P Athanasoulia-Kaspar, Matthias K Auer, Günter K Stalla, and Mira Jakovcevski

with conventional hydrocortisone usually divided into 2–3 doses per day. Secondary hypothyroidism was treated with levothyroxine. Gonadotropic insufficiency was treated with testosterone in men (in form of transdermal gel or intramuscular injections

Open access

Stephanie E Baldeweg, Mark Vanderpump, Will Drake, Narendra Reddy, Andrew Markey, Gordon T Plant, Michael Powell, Saurabh Sinha, John Wass, and the Society for Endocrinology Clinical Committee

potentially lifesaving in these patients In adults, hydrocortisone 100 mg i.m. bolus followed by 50–100 mg six hourly by intramuscular injection or 100–200 mg as an intravenous bolus followed by 2–4 mg per hour by continuous i.v. infusion can be used

Open access

C E Higham, A Olsson-Brown, P Carroll, T Cooksley, J Larkin, P Lorigan, D Morganstein, P J Trainer, and the Society for Endocrinology Clinical Committee

definitive diagnosis of adrenal insufficiency. Referral to endocrinology services is advised in all cases. Patients should be provided with a Steroid Emergency Card, education with regards to ‘sick day rules’, and an hydrocortisone emergency injection

Open access

Kathrin Zopf, Kathrin R Frey, Tina Kienitz, Manfred Ventz, Britta Bauer, and Marcus Quinkler

dose of hydrocortisone was lowered in recent years to an average of 20 mg per day. Failure of dose adaptations in situations with a high need for glucocorticoids is likely to lead to adrenal crisis (AC), which is a major threat to patients with AI ( 14

Open access

V Guarnotta, C Di Stefano, A Santoro, A Ciresi, A Coppola, and C Giordano

Introduction Adrenal insufficiency (AI) is characterized by high morbidity and mortality, likely due to inappropriate glucocorticoid (GC) treatment and no physiological daily exposure. Indeed, conventional GC treatment, with hydrocortisone (HC

Open access

Bruno Donadille, Muriel Houang, Irène Netchine, Jean-Pierre Siffroi, and Sophie Christin-Maitre

was taking daily 30 mg of hydrocortisone (17.3 mg/m²/day) and 75 µg of fludrocortisone. At the age of 20 years, he travelled back to Sri Lanka and did not present any acute adrenal insufficiency. A prophylactic 100 mg hydrocortisone injection has only