Lei Lei
Lei Lei
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Yi-Hua Bai
Yi-Hua Bai
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Hong-Ying Jiang
Hong-Ying Jiang
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Ting He
Ting He
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Meng Li
Meng Li
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Jia-Ping Wang
Jia-Ping Wang
Department of Radiology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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out as the hub gene for T2D, providing a new research direction for T2D molecular research. Materials and methods Data acquisition and processing The raw data of GSE120024, including 30 samples obtained from 7 T2D patients and 8 non
Xu Chen
Xu Chen
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Yi Tang
Yi Tang
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Shen Chen
Shen Chen
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Wenhua Ling
Wenhua Ling
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Qing Wang
Qing Wang
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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can be further mined to identify hub genes that can be targeted to treat hepatic steatosis. In this study, we combined two public datasets which have full histological data to identify differentially expressed genes (DEGs) between SS and healthy
Tian Zhou
Tian Zhou
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Dai-wei Zhao
Dai-wei Zhao
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Ning Ma
Ning Ma
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Xue-ying Zhu
Xue-ying Zhu
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Xing-hong Chen
Xing-hong Chen
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Xue Luo
Xue Luo
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Song Chen
Song Chen
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Qing-jun Gao
Qing-jun Gao
Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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construction We established a protein–protein interaction (PPI) network of FOXP4-related genes via the STRING database ( http://www.string-db.org/ ) ( 26 ). The cytoHubba plugin of the Cytoscape software was used to identify hub genes. Cytoscape was used for
Huifei Sophia Zheng
Huifei Sophia Zheng
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Jeffrey G Daniel
Jeffrey G Daniel
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Julia M Salamat
Julia M Salamat
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Laci Mackay
Laci Mackay
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Chad D Foradori
Chad D Foradori
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Robert J Kemppainen
Robert J Kemppainen
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Satyanarayana R Pondugula
Satyanarayana R Pondugula
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Ya-Xiong Tao
Ya-Xiong Tao
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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Chen-Che Jeff Huang
Chen-Che Jeff Huang
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama
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negative feedback from the hypothalamic–pituitary–adrenal (HPA) axis ( 2 ). Although GCs have non-genomic actions, they may still rapidly affect gene expression via different mechanisms such as mRNA destabilization and coactivator competition ( 3 , 4
Erika Urbano Lima
Erika Urbano Lima
Biological Science Department, Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Ileana G S Rubio
Ileana G S Rubio
Biological Science Department, Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
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Joaquim Custodio Da Silva
Joaquim Custodio Da Silva
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Ana Luiza Galrão
Ana Luiza Galrão
Biological Science Department, Thyroid Molecular Sciences Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
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Danielle Pêssoa
Danielle Pêssoa
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Taise Cerqueira Oliveira
Taise Cerqueira Oliveira
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Fabiane Carrijo
Fabiane Carrijo
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Igor Silva Campos
Igor Silva Campos
Department of Pathology, Sao Rafael Hospital, Salvador, Brazil
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Luciano Fonseca Espinheira
Luciano Fonseca Espinheira
Department of Pathology, Sao Rafael Hospital, Salvador, Brazil
Department of Anatomic Pathology & Legal Medicine, Bahia Federal Medical School, Federal University of Bahia, Salvador, Brazil
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Department of Anatomic Pathology & Legal Medicine, Bahia Federal Medical School, Federal University of Bahia, Salvador, Brazil
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Luiz Jose Sampaio
Luiz Jose Sampaio
Nuclear Medicine Department, Sao Rafael Hospital, Salvador, Brazil
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Claudio Rogerio Lima
Claudio Rogerio Lima
Head and Neck Surgery Department, Sao Rafael Hospital, Salvador, Brazil
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Janete Maria Cerutti
Janete Maria Cerutti
Structural and Functional Biology Program, Universidade Federal de São Paulo, São Paulo, Brazil
Division of Genetics, Department of Morphology and Genetics, Genetic Basis of Thyroid Tumors Laboratory, Paulista School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
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Division of Genetics, Department of Morphology and Genetics, Genetic Basis of Thyroid Tumors Laboratory, Paulista School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
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Helton Estrela Ramos
Helton Estrela Ramos
Department of Bio-regulation, Thyroid Study Laboratory, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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Post-graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Brazil
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affected by a growing number of DNA alterations in tumor-suppressor genes, especially via gene promoter methylation ( 4 ) causing a silencing of tumor-suppressor genes that are linked to apoptosis or DNA repair ( 5 , 6 ). A better understanding of such
P G Murray
P G Murray
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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D Hanson
D Hanson
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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T Coulson
T Coulson
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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A Stevens
A Stevens
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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A Whatmore
A Whatmore
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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R L Poole
R L Poole
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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D J Mackay
D J Mackay
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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G C M Black
G C M Black
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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P E Clayton
P E Clayton
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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2001 11 19R – 23R . ( doi:10.1093/glycob/11.3.19R ). 37 Pilia G Hughes-Benzie RM MacKenzie A Baybayan P Chen EY Huber R Neri G Cao A Forabosco A Schlessinger D . Mutations in GPC3, a glypican gene, cause the Simpson
Masatada Watanabe
Masatada Watanabe
Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan
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Shuji Ohno
Shuji Ohno
Division of Research for Pharmacy Students Education, Hoshi University, Shinagawa, Tokyo, Japan
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Hiroshi Wachi
Hiroshi Wachi
Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan
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number of transcripts of the CYP19A1 gene in human skin tissues ( 7 ). In vitro -cultured human skin fibroblast cells have been reported to express aromatase ( 8 , 9 ). Aromatase activity was induced in human skin fibroblasts by dexamethasone (Dex
Luis Eduardo Barbalho de Mello
Luis Eduardo Barbalho de Mello
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Thaise Nayane Ribeiro Carneiro
Thaise Nayane Ribeiro Carneiro
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
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Aline Neves Araujo
Aline Neves Araujo
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
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Camila Xavier Alves
Camila Xavier Alves
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Pedro Alexandre Favoretto Galante
Pedro Alexandre Favoretto Galante
Centro de Oncologia Molecular, Hospital Sírio-libanês, São Paulo, São Paulo, Brazil
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Vanessa Candiotti Buzatto
Vanessa Candiotti Buzatto
Centro de Oncologia Molecular, Hospital Sírio-libanês, São Paulo, São Paulo, Brazil
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Maria das Graças de Almeida
Maria das Graças de Almeida
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
Department of Clinical and Toxicological Analyses, Natal, Rio Grande do Norte, Brazil
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Department of Clinical and Toxicological Analyses, Natal, Rio Grande do Norte, Brazil
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Karina Marques Vermeulen-Serpa
Karina Marques Vermeulen-Serpa
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Sancha Helena de Lima Vale
Sancha Helena de Lima Vale
Department of Clinical and Toxicological Analyses, Natal, Rio Grande do Norte, Brazil
Department of Nutrition, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Department of Nutrition, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Fernando José de Pinto Paiva
Fernando José de Pinto Paiva
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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José Brandão-Neto
José Brandão-Neto
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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Janete Maria Cerutti
Janete Maria Cerutti
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
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Carney complex, Werner’s syndrome, phosphatase and tensin homologue gene (PTEN) hamartoma tumour syndrome (PHTS) and familial adenomatous polyposis (FAP), NMTC occurs as a minor component of familial cancer syndromes ( 2 , 3 ). As the predisposing genes
Anastasia K Armeni
Anastasia K Armeni
Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece
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Konstantinos Assimakopoulos
Konstantinos Assimakopoulos
Department of Psychiatry, University of Patras Medical School, Patras, Greece
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Dimitra Marioli
Dimitra Marioli
Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece
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Vassiliki Koika
Vassiliki Koika
Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece
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Euthychia Michaelidou
Euthychia Michaelidou
Department of Biology, University of Patras, Patras, Greece
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Niki Mourtzi
Niki Mourtzi
Department of Biology, University of Patras, Patras, Greece
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Gregoris Iconomou
Gregoris Iconomou
Department of Psychiatry, University of Patras Medical School, Patras, Greece
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Neoklis A Georgopoulos
Neoklis A Georgopoulos
Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece
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sensitivity ( 8 ). Estrogens binding to estrogen receptors (ERA or ERB) activate estrogen-responsive genes and stimulate ER-positive cell lines. Although single-nucleotide polymorphisms (SNPs) of ERB gene (rs1271572, rs4986938 and rs928554) have been
Weiwei He
Weiwei He
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Caoxin Huang
Caoxin Huang
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiulin Shi
Xiulin Shi
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Menghua Wu
Menghua Wu
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Han Li
Han Li
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Qiuhong Liu
Qiuhong Liu
School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xiaofang Zhang
Xiaofang Zhang
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Yan Zhao
Yan Zhao
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
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Xuejun Li
Xuejun Li
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Prevention and Treatment Center, Xiamen, China
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Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Prevention and Treatment Center, Xiamen, China
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development of NASH and the underlying key functional pathways. Materials and methods scRNA-seq data of NASH and healthy control liver tissues scRNA-seq data of NASH and healthy control liver tissues from Gene Expression Omnibus (GEO) were analyzed
