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Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller and Henning Grønbæk

epinephrine) stimulate lipolysis through the actions of adipose triglyceride lipase and hormone-sensitive lipase (HSL), which are rate-limiting enzymes in the conversion of triglycerides into glycerol and FFA. Increased rates of lipolysis elevate circulating

Open access

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz and Marek Strączkowski

catalyzed by the enzyme adipose triglyceride lipase (ATGL), encoded by PNPLA2 . Diacylglycerol is further hydrolyzed to monoacylglycerol and fatty acid with hormone-sensitive lipase (HSL), encoded by LIPE , and monoacylglycerol is ultimately hydrolyzed to

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Julie Smith, Jan Fahrenkrug, Henrik L Jørgensen, Christina Christoffersen and Jens P Goetze

; NPR-C: 5′-tga cac cat tcg gag aat ca, 3′-ttt cac ggt cct cag tag gg; HPRT: 5′-aag ctt gct ggt gaa aag ga, 3′-ttg cgc tca tct tag gct tt; TBP: 5′-taa tcc caa gcg att tgc tgc, 3′-ctt cac atc aca gct ccc ca; hormone-sensitive lipase (HSL): 5′-tgc tct tct

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Mohammed S Albreiki, Benita Middleton and Shelagh M Hampton

experimental animals ( 18 , 19 ) and humans ( 20 , 21 ). In addition, melatonin has been reported to influence insulin ( 16 ) and glucagon ( 22 ), which in turn affect enzymes involved in lipid metabolism such as hormone-sensitive lipase (HSL) and lipoprotein

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Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

, which stimulates the insulin-signaling pathway ( 66 ). In adipose tissue, GH is an important mediator of lipolysis and directly acts on hormone sensitive lipase and enhances the responsiveness for beta-adrenergic activity, which might explain higher

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Jana Ernst, Urszula Grabiec, Kathrin Falk, Faramarz Dehghani and Kristina Schaedlich

), monoacylglycerol lipase ( MAGL ), N-acylphosphatidylethanolamine phospholipase D ( NAPE-PLD ), TATA-box binding protein ( TBP ) and transient receptor potential vanilloid 1 ( TRPV1 ). Hormone assay Cell supernatants were collected to measure the

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J Chycki, A Zajac, M Michalczyk, A Maszczyk and J Langfort

circumstances intramuscular TG hydrolysis may at least partially substitute reduced accessibility of NEFA from plasma by adrenaline ( 23 ) and contraction ( 24 ) stimulation of hormone-sensitive lipase (HSL) within muscle cells. It seems that the efficiency of

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Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan and Anil Bhansali

levels of HDL-C. This is possibly due to a decrease in lipoprotein lipase activity and increase in hormone-sensitive lipase activity (26, 27) . This study observed a decrease in TGs, cholesterol, and LDL-C levels and an increment in HDL-C after 6-month r

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Maximilian Bielohuby, Martin Bidlingmaier and Uwe Schwahn

set of regulatory factors controlling metabolism and new, previously unknown circulating metabolic hormones are discovered in periodic intervals. In addition, known hormones can also become a ‘hot-topic’ with the need to develop novel or more sensitive

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Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey and Christopher J Kenyon

been identified: hormone-sensitive lipase ( Lipe ) ( 11 ) and more recently neutral cholesterol ester hydrolase ( Nceh1 ) ( 33 ). Control of hormone-sensitive lipase activity may be post-translational ( 34 ); Lipe expression is not significantly