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Tingting Shu, Zhigang Lv, Yuchun Xie, Junming Tang and Xuhua Mao

Introduction Hepcidin is synthesized and secreted primarily in the liver and is a key regulator in iron metabolism ( 1 , 2 ). In 2008, Kulaksiz et al. first reported that hepcidin was expressed in human and rat islet tissues and only

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Xuhua Mao, Hucheng Chen, Junmin Tang, Liangliang Wang and Tingting Shu

-toxicity leads to depressed Pdx-1 expression, causing downregulated insulin synthesis; JNK, FoxO1 and NF-κB have been confirmed as target molecules involved in the regulation of Pdx-1 expression ( 6 , 9 ). The peptide hepcidin, which was first isolated from

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Aleksandra Krygier, Ewelina Szczepanek-Parulska, Dorota Filipowicz and Marek Ruchała

cause of haematologic changes in GD, next to the thyroid hormone excess ( 8 ). Hepcidin is a liver-derived protein responsive to Fe plasma concentration and helps maintain proper iron status. It acts mainly through blockage of Fe transporters in the

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Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan and Chuang Guo

washed, treated with 5% bovine serum albumin for 30 min and subsequently incubated overnight with rabbit anti-Hepcidin (1:100; Santa Cruz Biotechnology) at 4°C. The sections were rinsed and then incubated with biotinylated goat anti-rabbit IgG (1:200) for

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Angelica Lindén Hirschberg

. Furthermore, testosterone stimulates the formation of new erythrocytes and elevates circulating levels of hemoglobin ( 45 ), apparently as a result of secretion of more erythropoietin and less hepcidin ( 46 ). Experiments performed in the 1970s revealed a

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Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian A Groth, Kurt Kristensen, Anne Grethe Jurik, Niels H Birkebæk and Claus H Gravholt

treatment, the level was still somewhat lower than among controls. The testosterone-induced increase in hemoglobin seems to occur via increased erythropoietin and decreased ferritin and hepcidin ( 27 ). Due to the design of the study with withdrawal of study