Lena-Maria Levin
Lena-Maria Levin
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
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Henry Völzke
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
DZD (German Center for Diabetes Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
DZD (German Center for Diabetes Research), Greifswald, Germany
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Markus M Lerch
Markus M Lerch
Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
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Jens-Peter Kühn
Jens-Peter Kühn
Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
Institute and Policlinic for Radiology and Interventional Radiology, University Hospital, Carl-Gustav-Carus University Dresden, Dresden, Germany
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Institute and Policlinic for Radiology and Interventional Radiology, University Hospital, Carl-Gustav-Carus University Dresden, Dresden, Germany
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Matthias Nauck
Matthias Nauck
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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Nele Friedrich
Nele Friedrich
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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Stephanie Zylla
Stephanie Zylla
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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Introduction In industrialized countries, the prevalence and incidence of hepatic steatosis have steadily increased over the past decades ( 1 ). Besides excessive alcohol consumption, obesity and other metabolic disorders have been frequently
Xu Chen
Xu Chen
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Yi Tang
Yi Tang
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
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Shen Chen
Shen Chen
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Wenhua Ling
Wenhua Ling
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Qing Wang
Qing Wang
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China
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can be further mined to identify hub genes that can be targeted to treat hepatic steatosis. In this study, we combined two public datasets which have full histological data to identify differentially expressed genes (DEGs) between SS and healthy
Helle Keinicke
Helle Keinicke
Insulin and Device Trial Operations, Novo Nordisk A/S, Søborg, Denmark
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Gao Sun
Gao Sun
Pharmacology and Histopathology, Novo Nordisk A/S, China
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Caroline M Junker Mentzel
Caroline M Junker Mentzel
Department of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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Merete Fredholm
Merete Fredholm
Department of Veterinary Clinical and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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Linu Mary John
Linu Mary John
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Birgitte Andersen
Birgitte Andersen
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Kirsten Raun
Kirsten Raun
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Marina Kjaergaard
Marina Kjaergaard
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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has multiple effects on the liver either by direct or indirect actions ( 11 ). For instance, FGF21 has been shown to reduce hepatic steatosis through increased fatty acid (FA) oxidation and decreased lipogenesis in rodents ( 11 ). Moreover, an FGF21
Silan Zheng
Silan Zheng
School of Medicine, Xiamen University, Xiamen, China
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Meifeng Tong
Meifeng Tong
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Lianqin Dong
Lianqin Dong
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
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Chunmin Du
Chunmin Du
School of Medicine, Xiamen University, Xiamen, China
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Xin Zheng
Xin Zheng
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Liying Wang
Liying Wang
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Peiying Huang
Peiying Huang
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Wei Liu
Wei Liu
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Mingzhu Lin
Mingzhu Lin
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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Changqin Liu
Changqin Liu
Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
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The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
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most common forms of liver diseases, which is typically characterized by more than 5% accumulation of hepatocellular lipids and comprises a spectrum of disease stages ranging from simple hepatic steatosis (HS) to nonalcoholic steatohepatitis (NASH) ( 4
Stephen J Winters
Stephen J Winters
Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA
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Charles R Scoggins
Charles R Scoggins
Division of Surgical Oncology, University of Louisville, Louisville, Kentucky, USA
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Duke Appiah
Duke Appiah
Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
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Dushan T Ghooray
Dushan T Ghooray
Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA
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linoleic (18:2), stearic (18:0), arachidonic (20:4), palmitoleic (16:1) and myristic (14:0) acids ( Table 1 ). Table 1 Clinical characteristics and hepatic fatty acid composition in individuals with steatosis compared to the low-fat group
Agnieszka Adamska
Agnieszka Adamska
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
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Aleksandra Maria Polak
Aleksandra Maria Polak
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Anna Krentowska
Anna Krentowska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Agnieszka Łebkowska
Agnieszka Łebkowska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Justyna Hryniewicka
Justyna Hryniewicka
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
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Monika Leśniewska
Monika Leśniewska
Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, Poland
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Irina Kowalska
Irina Kowalska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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as in patients with coronary artery disease, in comparison to healthy controls ( 14 ). Fetuin-B appears to be a hepatokine that becomes dysregulated in hepatic steatosis and insulin resistance. However, no evidence regarding the association between
Tatsuya Kondo
Tatsuya Kondo
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Nobukazu Miyakawa
Nobukazu Miyakawa
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Sayaka Kitano
Sayaka Kitano
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Takuro Watanabe
Takuro Watanabe
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Rieko Goto
Rieko Goto
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Mary Ann Suico
Mary Ann Suico
Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Miki Sato
Miki Sato
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Yuki Takaki
Yuki Takaki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Masaji Sakaguchi
Masaji Sakaguchi
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Motoyuki Igata
Motoyuki Igata
Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan
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Junji Kawashima
Junji Kawashima
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Hiroyuki Motoshima
Hiroyuki Motoshima
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Takeshi Matsumura
Takeshi Matsumura
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Hirofumi Kai
Hirofumi Kai
Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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Eiichi Araki
Eiichi Araki
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan
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from simple hepatic steatosis to its inflammatory variant, nonalcoholic steatohepatitis (NASH); progressive fibrosis; cirrhosis and eventually hepatocellular carcinoma in the absence of significant alcohol consumption. NAFLD is considered an important
Xiaonan Guo
Xiaonan Guo
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Wenjing Hu
Wenjing Hu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Xiaorui Lyu
Xiaorui Lyu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Hanyuan Xu
Hanyuan Xu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Huijuan Zhu
Huijuan Zhu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Hui Pan
Hui Pan
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Linjie Wang
Linjie Wang
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Hongbo Yang
Hongbo Yang
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Fengying Gong
Fengying Gong
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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/dw rats to explore the characterizations of hepatic metabolic profiles and their relationship with liver function. We found that (1) dw/dw rats represented reduced serum IGF-1 levels, increased AST and ALT levels, and more obvious hepatic steatosis
Frederique Van de Velde
Frederique Van de Velde
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
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Marlies Bekaert
Marlies Bekaert
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
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Anja Geerts
Anja Geerts
Department of Hepatology, Ghent University Hospital, Ghent, Belgium
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Anne Hoorens
Anne Hoorens
Department of Pathology, Ghent University Hospital
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Arsène-Hélène Batens
Arsène-Hélène Batens
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
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Samyah Shadid
Samyah Shadid
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
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Margriet Ouwens
Margriet Ouwens
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
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Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
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Yves Van Nieuwenhove
Yves Van Nieuwenhove
Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium
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Bruno Lapauw
Bruno Lapauw
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
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. Recent experimental work suggested that excess accumulation of diacylglycerol (DAG) in hepatocytes, rather than hepatic steatosis per se (intrahepatic triglyceride (TG) content), is the main molecular mechanism of development of IR ( 7 , 8 ). Until now
Robert Maidstone
Robert Maidstone
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Martin K Rutter
Martin K Rutter
Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK
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Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK
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Thomas Marjot
Thomas Marjot
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK
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Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK
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David W Ray
David W Ray
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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Matthew Baxter
Matthew Baxter
Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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.1 Depression (%) 4.63 5.09 4.72 Cardiovascular disease (%) 3.72 4.24 4 Dallas steatosis index (DSI) −2.65 (1.39) −2.42 (1.42) −2.26 (1.4) Data are mean ( s.d. ) or percentages. DSI (Dallas steatosis index) is defined in
