Ruixin Hu
Ruixin Hu
School of pharmacy, Qing Dao University, Qingdao, China
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Yanting Yuan
Yanting Yuan
School of pharmacy, Qing Dao University, Qingdao, China
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Chaolong Liu
Chaolong Liu
School of pharmacy, Qing Dao University, Qingdao, China
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Ji Zhou
Ji Zhou
School of pharmacy, Qing Dao University, Qingdao, China
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Lixia Ji
Lixia Ji
School of pharmacy, Qing Dao University, Qingdao, China
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Guohui Jiang
Guohui Jiang
School of pharmacy, Qing Dao University, Qingdao, China
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abundance of gut microbiota ( Table 1 ). After metformin treatment on obese mice, the total amount of SCFAs in feces increased; the number of Akkermansia muciniphila , Clostridium cocleatum and the phylum Bacteroidetes elevated; the number of Prevotella
Ling Zhou
Ling Zhou
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Zhexin Ni
Zhexin Ni
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Wen Cheng
Wen Cheng
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Jin Yu
Jin Yu
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Shuai Sun
Shuai Sun
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Dongxia Zhai
Dongxia Zhai
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Chaoqin Yu
Chaoqin Yu
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Zailong Cai
Zailong Cai
Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China
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IR, promoting the development of PCOS ( 2 ). The interrelation between gut microbiota and PCOS is attracting increased attention. Compared with healthy women, Lindheim et al . ( 3 ) found that the abundance of ML615J-28 and 124-7 from phylum
Lilit Egshatyan
Lilit Egshatyan
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Daria Kashtanova
Daria Kashtanova
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Anna Popenko
Anna Popenko
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Olga Tkacheva
Olga Tkacheva
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Alexander Tyakht
Alexander Tyakht
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Dmitry Alexeev
Dmitry Alexeev
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Natalia Karamnova
Natalia Karamnova
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Elena Kostryukova
Elena Kostryukova
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Vladislav Babenko
Vladislav Babenko
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Maria Vakhitova
Maria Vakhitova
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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Sergey Boytsov
Sergey Boytsov
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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592 million by 2035 (5) . Recently, it has been established that the human gut microbiota (GM) plays key roles in health maintenance. The GM is altered in the development of chronic inflammation, T2DM, atherosclerosis, hypertension, and many other
Ying Pei
Ying Pei
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Rui Wang
Rui Wang
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Wanyu Chen
Wanyu Chen
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Shulin Yi
Shulin Yi
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Chen Huang
Chen Huang
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Shaochan Liang
Shaochan Liang
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Hongying Cao
Hongying Cao
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Yifei Xu
Yifei Xu
Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China
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Bo Tan
Bo Tan
Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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colonic neuromuscular function and motility via excitatory and inhibitory neurotransmitters (acetylcholine, nitric oxide, and VIP, respectively) ( 8 , 9 , 10 ). For decades, research has focused on the role of the gut microbiota in ENS homeostasis and
Aaron Lerner
Aaron Lerner
B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
AESKU.KIPP Institute, Wendelsheim, Germany
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AESKU.KIPP Institute, Wendelsheim, Germany
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Patricia Jeremias
Patricia Jeremias
AESKU.KIPP Institute, Wendelsheim, Germany
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Torsten Matthias
Torsten Matthias
AESKU.KIPP Institute, Wendelsheim, Germany
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) not less important is the transcriptomic, proteinomic and the metabolomics changes induced by the gut microbes, being direct messengers between the bugs and us. Changes in microbiota and short chain fatty acids production are clearly related to the
Niels B Dalsgaard
Niels B Dalsgaard
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Lærke S Gasbjerg
Lærke S Gasbjerg
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Laura S Hansen
Laura S Hansen
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Dennis S Nielsen
Dennis S Nielsen
Department of Food Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
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Torben S Rasmussen
Torben S Rasmussen
Department of Food Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
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Filip K Knop
Filip K Knop
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark
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lifespan of primates) and time to the introduction of acarbose to their respective gut microbiome remains unknown. It is noteworthy that microbiota composition in each intestinal segment is different, and the analysis of mucosal rather than faecal
Yao Su
Yao Su
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Li Chen
Li Chen
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Dong-Yao Zhang
Dong-Yao Zhang
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xu-Pei Gan
Xu-Pei Gan
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yan-Nan Cao
Yan-Nan Cao
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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De-Cui Cheng
De-Cui Cheng
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Wen-Yu Liu
Wen-Yu Liu
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Fei-Fei Li
Fei-Fei Li
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xian-Ming Xu
Xian-Ming Xu
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hong-Kun Wang
Hong-Kun Wang
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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intervention and evaluation components of the study. References 1 Tremaroli V Bäckhed F . Functional interactions between the gut microbiota and host metabolism . Nature 2012 489 242 – 249 . ( https://doi.org/10.1038/nature11552 ) 2 Salah M Azab M
Yinqiong Huang
Yinqiong Huang
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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Zhaozhao Zhu
Zhaozhao Zhu
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China
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Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China
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Zhiqin Huang
Zhiqin Huang
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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Jingxiong Zhou
Jingxiong Zhou
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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showed gut microbiota-dependent TMAO may be associated with the development of T2DM. The addition of TMAO to the diet has been reported to increase fasting insulin levels and insulin resistance in mice, exacerbating impaired glucose tolerance ( 9 ). TMAO
Emmi Naskali
Emmi Naskali
Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
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Katja Dettmer
Katja Dettmer
Institute of Functional Genomics, University of Regensburg, Regensburg, Germany
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Peter J Oefner
Peter J Oefner
Institute of Functional Genomics, University of Regensburg, Regensburg, Germany
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Pedro A B Pereira
Pedro A B Pereira
Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland
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Kai Krohn
Kai Krohn
Clinical Research Institute HUCH Ltd, Biomedicum Helsinki 1, Helsinki, Finland
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Petri Auvinen
Petri Auvinen
Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland
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Annamari Ranki
Annamari Ranki
Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
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Nicolas Kluger
Nicolas Kluger
Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
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Finnish APECED patients and compared the results with the presence of TPH-1, TPH-2 and AADC Aabs and with clinical manifestations such as GI dysfunction and depressive symptoms. We also compared the gut microbiota of APECED patients against that of healthy
Stavroula A Paschou
Stavroula A Paschou
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Nektaria Papadopoulou-Marketou
Nektaria Papadopoulou-Marketou
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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George P Chrousos
George P Chrousos
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Christina Kanaka-Gantenbein
Christina Kanaka-Gantenbein
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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1. Viruses (rubella, enteroviruses) 2. Diet (cow’s milk, cereals, omega-3 fatty acids, vitamin D) 3. Gut microbiota D. Immunologic factors 1. Immune tolerance (central, peripheral, Tregs) 2. Cellular immunity
