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S E Baldeweg, S Ball, A Brooke, H K Gleeson, M J Levy, M Prentice, J Wass and the Society for Endocrinology Clinical Committee

could be perceived as prejudicing the impartiality of this guideline. Funding This work did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. Disclaimer The document should be

Open access

Stefan Pilz, Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz, Elisabeth Lerchbaum, Martin H Keppel, Martin R Grübler, Winfried März and Marlene Pandis

) 2017 Clinical Practice Guideline’ that vitamin D deficiency and insufficiency be corrected by vitamin D supplementation using treatment strategies recommended for the general population ( 107 ). Parathyroid diseases also require particular attention

Open access

Malachi J McKenna and Barbara F Murray

Introduction Two conflicting reports on vitamin D intake requirements were published in 2011: Institute of Medicine (IOM) report on Dietary Reference Intakes for Calcium and Vitamin D and the Endocrine Society's Clinical Practice Guideline (CPG

Open access

Yang Lv, Ning Pu, Wei-lin Mao, Wen-qi Chen, Huan-yu Wang, Xu Han, Yuan Ji, Lei Zhang, Da-yong Jin, Wen-Hui Lou and Xue-feng Xu

Aim

We aim to investigate the clinical characteristics of the rectal NECs and the prognosis-related factors and construct a nomogram for prognosis prediction.

Methods

The data of 41 patients and 1028 patients with rectal NEC were retrieved respectively from our institution and SEER database. OS or PFS was defined as the major study outcome. Variables were compared by chi-square test and t-test when appropriate. Kaplan–Meier analysis with log-rank test was used for survival analysis and the Cox regression analysis was applied. The nomogram integrating risk factors for predicting OS was constructed by R to achieve superior discriminatory ability. Predictive utility of the nomogram was determined by concordance index (C-index) and calibration curve.

Results

In the univariate and multivariate analyses, tumor differentiation, N stage, M stage and resection of primary site were identified as independent prognostic indicators. The linear regression relationship was found between the value of Ki-67 index and the duration of OS (P < 0.05). Furthermore, the independent prognostic factors were added to formulate prognostic nomogram. The constructed nomogram showed good performance according to the C-index.

Conclusions

Contrary to WHO classification guideline, we found that the rectal NEC diseases are heterogeneous and should be divided as different categories according to the pathological differentiation. Besides, the nomogram formulated in this study showed excellent discriminative capability to predict OS for those patients. More advanced predictive model for this disease is required to assist risk stratification via the formulated nomogram.

Open access

Marie Freel

this guideline is Professor Weibke Arlt who was also an author on the Endocrine Society Clinical Practice Guideline and the diagnosis and treatment of primary adrenal insufficiency published in 2016 ( 2 ). Severe symptomatic hyponatraemia ( 3 ): this

Open access

Jeremy Turner, Neil Gittoes, Peter Selby and the Society for Endocrinology Clinical Committee

therapy as early as possible. This guideline aims to take the non-specialist through the initial phase of assessment and management. Clinical presentation Symptoms of hypocalcaemia typically develop when adjusted serum calcium levels fall below

Open access

Stephanie E Baldeweg, Mark Vanderpump, Will Drake, Narendra Reddy, Andrew Markey, Gordon T Plant, Michael Powell, Saurabh Sinha, John Wass and the Society for Endocrinology Clinical Committee

suspicion is essential to diagnose this condition as prompt management may be life and vision saving. This guideline aims to take the non-specialist through the initial phase of assessment and management. Clinical presentation The diagnosis of

Open access

Jennifer Walsh, Neil Gittoes, Peter Selby and the Society for Endocrinology Clinical Committee

to fail and serum calcium to rise. Serum calcium is bound to albumin, and measurements should be adjusted for serum albumin. This guideline aims to take the non-specialist through the initial phase of assessment and management. Severity of

Open access

Stephen Ball, Julian Barth, Miles Levy and the Society for Endocrinology Clinical Committee

guidance, is outlined in Fig. 3 ( 1 , 4 ). Figure 3 Diagnostic algorithm for patients presenting with hyponatraemia. For use following emergency treatment. Disclaimer The document should be considered as a guideline only; it is

Open access

Wiebke Arlt and the Society for Endocrinology Clinical Committee

and prompt management can save lives. This guideline aims to take the non-specialist through the initial phase of assessment and management. Underlying conditions Primary adrenal insufficiency is caused by loss of function of the adrenal gland