Search Results

You are looking at 1 - 10 of 29 items for :

  • growth hormone insensitivity x
Clear All
Open access

Sumana Chatterjee, Emily Cottrell, Stephen J Rose, Talat Mushtaq, Avinaash V Maharaj, Jack Williams, Martin O Savage, Louise A Metherell and Helen L Storr

Introduction Growth hormone insensitivity (GHI) is characterised by growth failure, IGF1 deficiency and normal or elevated GH levels. GHI encompasses a spectrum of genetic, phenotypic and biochemical abnormalities associated with growth

Open access

Werner F Blum, Abdullah Alherbish, Afaf Alsagheir, Ahmed El Awwa, Walid Kaplan, Ekaterina Koledova and Martin O Savage

Rosenfeld RG Savage MO. Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity . Endocrine Reviews 2011 32 472 – 497 . ( ) 10.1210/er.2010

Open access

Kennett Sprogøe, Eva Mortensen, David B Karpf and Jonathan A Leff

-I deficiency due to growth hormone insensitivity. Journal of Clinical Endocrinology and Metabolism 2007 92 902 – 910 . ( doi:10.1210/jc.2006-1610 ) 10.1210/jc.2006-1610 61 LeRoith D Yakar S . Mechanisms of disease: metabolic effects of growth

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen and on behalf of the Growth Hormone Research Society

). The requirement for rigorous procedures utilizing biomarkers in drug development is evident and recognized ( 2 , 5 ). The obvious biomarkers of growth hormone (GH) action in children and adults are serum levels of GH itself and of insulin-like growth

Open access

R Walia, M Singla, K Vaiphei, S Kumar and A Bhansali

origin. The presence of Mullerian structures in general suggests either a female genetic sex or gonadal dysgenesis in a genetic male with inadequate production of ­anti-Mullerian hormone (AMH). Sex of rearing depends on the genetic sex, degree of

Open access

Iben Katinka Greiber, Casper P Hagen, Alexander Siegfried Busch, Mikkel Grunnet Mieritz, Lise Aksglæde, Katharina Main, Kristian Almstrup and Anders Juul

.1016/0092-8674(86)90783-X ) 3754790 10.1016/0092-8674(86)90783-X 4 Imbeaud S Faure E Lamarre I Mattéi MG di Clemente N Tizard R Carré-Eusèbe D Belville C Tragethon L Tonkin C , Insensitivity to anti-Müllerian hormone due to a mutation in the human anti

Open access

R Solomon-Zemler, L Basel-Vanagaite, D Steier, S Yakar, E Mel, M Phillip, L Bazak, D Bercovich, H Werner and L de Vries

Rosenfeld RG Savage MO . Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity . Endocrine Reviews 2011 32 472 – 497 . ( doi:10.1210/er.2010-0023 ) 22 Greulich WW

Open access

Jintao Hu, Qingbo Chen, Xiao Ding, Xin Zheng, Xuefeng Tang, Song Li and Hui Yang

Background Pituitary adenoma (PA) is the second most common brain tumor. Except for prolactinoma, pituitary tumors associated with acromegaly (growth hormone-secreting) and Cushing’s disease (adrenocorticotropic hormone-secreting) as well as

Open access

Ananda A Santana-Ribeiro, Giulliani A Moreira-Brasileiro, Manuel H Aguiar-Oliveira, Roberto Salvatori, Vitor O Carvalho, Claudia K Alvim-Pereira, Carlos R Araújo-Daniel, Júlia G Reis-Costa, Alana L Andrade-Guimarães, Alécia A Oliveira-Santos, Edgar R Vieira and Miburge B Gois-Junior

pressure data in 31 isolated growth hormone deficiency (IGHD) and 40 controls. Data are expressed as mean ± standard deviation. IGHD Controls P value Sex (Males) 16 20 1.000 Age (years) 46 ± 12 43 ± 11 0

Open access

Angelica Lindén Hirschberg

insulin and insulin-like growth factor I (IGF-I) and high levels of growth hormone and IGF-binding protein-1 ( Fig. 1 ) ( 4 , 7 , 8 ). Because IGF-I stimulates the release of both GnRH and LH, a decline in IGF-I activity may, at least in part, explain