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in patients with pS6K1-positive than -negative tumors. Estrogen depletion therapy was developed for treating HR-positive breast cancer in recent decades. Gonadotropin-releasing hormone (GnRH) agonists are specific estradiol depletion therapy for
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Hematology Department, Fundeni Hospital, Bucharest, Romania
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Endocrine Department, Elias Hospital, Bucharest, Romania
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review from reliable electronic databases conducted between October 2016 and April 2017 using the following key words related to the topic: ‘gonadotropin-releasing hormone analogues’, ‘GnRHa’, ‘luteinizing hormone-releasing hormone agonist’, ‘LHRHa
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–pituitary–gonadal (HPG) axis. Within the HPG axis, reproductive function is regulated by gonadotropin-releasing hormone (GnRH) neurons located in the hypothalamus, which control the production and release of gonadotropins from the pituitary to regulate gonadal function
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Introduction The gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are released from the gonadotropic cells in the anterior pituitary gland. In men, the main target cells for LH are Leydig cells with subsequent
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Imperial College London, Institute of Reproductive and Developmental Biology, London, UK
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Malmö University Hospital, Reproductive Medicine Center, Malmö, Sweden
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Introduction For decades, gonadotropin-releasing hormone (GnRH) agonists have formed the mainstay hormonal treatment of prostate cancer ( 1 ). While they generate suppression of testosterone due to persistent suppression of luteinizing hormone
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seeking to conceive, 1 patient unsuccessfully underwent pulsatile gonadotropin-releasing hormone (GnRH) treatment. Ten patients underwent ovulation induction with gonadotropin, including 4 women who became pregnant and 2 women who failed and gave up
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Introduction Congenital hypogonadotropic hypogonadism (CHH) is characterised by partial or complete lack of pubertal development, secondary to deficient gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion ( 1 ). Diagnosis is
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
Mount Auburn Hospital, Harvard Medical School Teaching Hospital, Cambridge, Massachusetts, USA
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Introduction Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a rare disease with a wide spectrum of reproductive and non-reproductive clinical characteristics. Apart from the phenotypic heterogeneity, IGD is also a
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brain culminate in a signal to the pituitary gland to release the gonadotropins (GTHs). The pituitary GTHs include follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and together are responsible for gametogenesis, steroidogenesis, protein
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– 141 . ( https://doi.org/10.1016/j.mce.2017.10.015 ) 52 Melamed P Haj M Yosefzon Y Rudnizky S Wijeweera A Pnueli L Kaplan A . Multifaceted targeting of the chromatin mediates gonadotropin-releasing hormone effects on gene expression in the