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Daiki Kobayashi Division of General Internal Medicine Department of Medicine, St. Luke’s International Hospital, Tokyo, Japan
Department of Epidemiology St. Luke’s International University Graduate School of Public Health, Tokyo, Japan
Fujita Health University Toyoake, Japan

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Nagato Kuriyama Department of Epidemiology for Community Health and Medicine Kyoto Prefectural University of Medicine, Kyoto, Japan

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Keita Hirano Department of Nephrology Kyoto University Graduate School of Medicine, Kyoto, Japan

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Osamu Takahashi Division of General Internal Medicine Department of Medicine, St. Luke’s International Hospital, Tokyo, Japan
Department of Epidemiology St. Luke’s International University Graduate School of Public Health, Tokyo, Japan

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Hiroshi Noto Department of Endocrinology St. Luke’s International Hospital, Tokyo, Japan

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. Although the association of diabetes with malignancies among diabetic patients compared to nondiabetic patients has been well evaluated, the differences in the incidence of malignancies among diabetic patients in terms of the level of glycemic control are

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Zhou-Qing Kang Department of Nursing, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, Liaoning Province, China

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Jia-Ling Huo Department of Respiratory Medicine, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, Liaoning Province, China

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Xiao-Jie Zhai Department of Nursing, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, Liaoning Province, China

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was the first use of glucose range 80–110 mg/dL to define tight glycemic control (TGC), and then tight control of glycemic target became popular. Many researchers have made attempt to practice perioperative TGC with different upper level of glucose

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Xiuzhen Zhang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Dan Xu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Ping Xu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Shufen Yang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Qingmei Zhang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Yan Wu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Fengyi Yuan Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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atherosclerosis in T1DM patients, which was primarily ascribed to the reduction in hemoglobin A1c (HbA1c) level ( 5 ). As the standard metric of glycemic control, the HbA1c level is ideally maintained as close to normal as possible for the purpose of reducing the

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Louise Færch Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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Anders Juul Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark
Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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Ulrik Pedersen-Bjergaard Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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Birger Thorsteinsson Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark
Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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cohort of nonpregnant adult patients with type 1 diabetes and to explore whether a similar association exists with mild and biochemical hypoglycemia and with glycemic control as indicated by HbA1c levels. Materials and methods The study is a post hoc

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Annalisa Blasetti Department of Paediatrics, University of Chieti, Chieti, Italy

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Valeria Castorani Department of Paediatrics, University of Chieti, Chieti, Italy

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Nella Polidori Department of Paediatrics, University of Chieti, Chieti, Italy

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Ilaria Mascioli Department of Paediatrics, University of Chieti, Chieti, Italy

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Francesco Chiarelli Department of Paediatrics, University of Chieti, Chieti, Italy

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Cosimo Giannini Department of Paediatrics, University of Chieti, Chieti, Italy

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Introduction Type 1 diabetes (T1D) and other chronic diseases are well recognized to adversely affect linear growth in childhood. Indeed, early studies have shown that suboptimal glycemic control and longer disease duration can impair

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Aldo Bonaventura Department of Internal Medicine, Division of Cardiology, Division of Laboratory Medicine, First Clinic of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

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Fabrizio Montecucco Department of Internal Medicine, Division of Cardiology, Division of Laboratory Medicine, First Clinic of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Department of Internal Medicine, Division of Cardiology, Division of Laboratory Medicine, First Clinic of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Department of Internal Medicine, Division of Cardiology, Division of Laboratory Medicine, First Clinic of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

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Franco Dallegri Department of Internal Medicine, Division of Cardiology, Division of Laboratory Medicine, First Clinic of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

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and compliance with achieving good glycemic control that minimizes the risk of diabetic complications, with a consequent increase in cardiovascular (CV) and neurological morbidities. In this review, based on the material searched for and obtained via

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Vânia Benido Silva Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Liliana Fonseca Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Maria Teresa Pereira Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Joana Vilaverde Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Clara Pinto Department of Obstetrics, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Fernando Pichel Department of Nutrition, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Maria do Céu Almeida In representation of the Diabetes and Pregnancy Study Group of the Portuguese Society of Diabetology, Lisbon, Portugal

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Jorge Dores Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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, 7 , 8 ). These adverse pregnancy outcomes can be minimized by an optimized glycemic control ( 7 , 8 ). The recommended initial treatment is centered in lifestyle modifications, supported by an individualized medical nutrition therapy and a daily

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Peter Wolf Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Alexandre Dormoy Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Luigi Maione Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Sylvie Salenave Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Jacques Young Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Peter Kamenický Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Philippe Chanson Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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( 4 ). Glycemic control is associated with disease activity ( 5 ), but the effects of GH-lowering therapy on glucose metabolism depend on the chosen therapeutic modality. Whereas pituitary surgery and treatment with the GH receptor antagonist

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Hathairat Rueangdetnarong Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Rattanaporn Sekararithi Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Thidarat Jaiwongkam Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Sirinart Kumfu Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Theera Tongsong Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Phudit Jatavan Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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develop overt diabetes mellitus later in life or 20 years later ( 4 ). Therefore, we hypothesize that women with GDM with high oxidative stress markers, even in the case of good glycemic control, may have a higher chance of developing DM type 2 later in

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Hoda Gad Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Einas Elgassim Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Ibrahim Mohammed Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
Department of Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA

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Ahmad Yaser Alhaddad Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar

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Hussein Ahmed Hussein Zaky Aly KINDI Center for computing research, Qatar University, Doha, Qatar

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John-John Cabibihan Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar

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Abdulaziz Al-Ali KINDI Center for computing research, Qatar University, Doha, Qatar

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Kishor Kumar Sadasivuni Center for Advanced Materials, Qatar University, Doha, Qatar

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Aliyaa Haji Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Neila Lamine Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Adnan Khan Faculty of Healthy Sciences, Khyber Medical University, Peshawar, Pakistan

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Ioannis N Petropoulos Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Georgios Ponirakis Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Alise Kalteniece Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Maryam Ferdousi Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Shazli Azmi Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Uazman Alam Diabetes and Neuropathy Research, Department of Eye and Vision Sciences and Pain Research Institute, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, UK
Department of Diabetes and Endocrinology, Royal Liverpool and Broadgreen University NHS Hospital Trust, Liverpool, UK
Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, UK

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Wajeeha Abuhelaiqa Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Amin Jayyousi Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Dabia AlMohanadi Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Khaled Baagar Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Rayaz A Malik Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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lower limb amputation ( 1 ). Recognized risk factors for DPN include poor glycemic control, obesity, hypertension and dyslipidemia ( 3 , 4 ). However, HbA1c provides limited insight into the short-term variations in blood glucose, which may affect nerve

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