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Yao Chen and Shu-ying Fang

steroid biosynthesis and action, gonadotropic secretion and action, folliculogenesis, weight and energy regulation and insulin action ( 13 ). In this review, we aimed to provide an overview of the main genetic polymorphisms that were found or

Open access

Piera Rizzolo, Valentina Silvestri, Virginia Valentini, Veronica Zelli, Agostino Bucalo, Ines Zanna, Simonetta Bianchi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Gianluca Tedaldi, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Alessandra Viel, Marco Montagna, Paolo Peterlongo, Paolo Radice, Domenico Palli and Laura Ottini

, increase the risk of developing MBC ( 2 , 3 , 4 ). Common polymorphisms may also contribute to MBC genetic predisposition and may have a modifying effect on BC risk for male BRCA1/2 mutation carriers, particularly through a polygenic inheritance model

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Anastasia K Armeni, Konstantinos Assimakopoulos, Dimitra Marioli, Vassiliki Koika, Euthychia Michaelidou, Niki Mourtzi, Gregoris Iconomou and Neoklis A Georgopoulos

oxytocin has been shown to increase expression of ERα ( 28 ). Therefore, the interaction of these two genetic polymorphisms could have an additive effect on female sexuality. The aim of the present study was to investigate the correlation of estrogen

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Dmitry M Davydov and Malik K Nurbekov

differences between the groups was found in genotype or allele frequency of the other two genetic polymorphisms. Table 2 Genotype frequencies of studied loci in patients with diabetes and controls without diabetes Groups: Diabetes Control

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Kathrin Zopf, Kathrin R Frey, Tina Kienitz, Manfred Ventz, Britta Bauer and Marcus Quinkler

Introduction Polymorphisms of the glucocorticoid receptor (GR) may influence the sensitivity to glucocorticoids by altering the GR expression (e.g. reducing transcription) and influencing transactivation and transrepression of target genes

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Katica Bajuk Studen and Marija Pfeifer

and its different phenotypes result from complex interactions between multiple genetic predisposing variants and environmental and lifestyle factors ( 2 ). Possible associations between several genetic polymorphisms in PCOS in relation to its metabolic

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Susana Pastor, Abdelmounaim Akdi, Eddy R González, Juan Castell, Josefina Biarnés, Ricard Marcos and Antonia Velázquez

the susceptibility to DTC significantly, suggesting a lack of influence of these polymorphisms on the development of DTC. Indeed, the role of TSHR in thyroid cancer is not clear; however, it is a major thyroid autoantigen, and genetic variants in the

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Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

. Journal of Endocrinological Investigation 2013 [in press] . 26 Srivastava K Srivastava A . Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk . PLoS ONE 2012 7 e50966 . ( doi:10

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Kirsty G Pringle, Sarah J Delforce, Yu Wang, Katie A Ashton, Anthony Proietto, Geoffrey Otton, C Caroline Blackwell, Rodney J Scott and Eugenie R Lumbers

can often be attributed to single nucleotide polymorphisms (SNPs) in RAS genes. In this study, we measured the prevalence of five polymorphisms in RAS genes in Australian women with EC and in healthy controls. These polymorphisms were AGT (rs699

Open access

Renata C Scalco, Ericka B Trarbach, Edoarda V A Albuquerque, Thais K Homma, Thais H Inoue-Lima, Mirian Y Nishi, Berenice B Mendonca and Alexander A L Jorge

height, breast development and uterine volume, the high variability especially of the latter suggests that genetic variants play an important role. More efforts to identify polymorphisms associated with estrogen outcomes may allow for individualization of