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Anna-Pauliina Iivonen, Johanna Känsäkoski, Kirsi Vaaralahti and Taneli Raivio

, and over 60% of human protein-coding genes are miRNA targets ( 5 ). The significance of miRNAs in the hypothalamus–pituitary–gonadal system regulation has been shown in several animal models. Garaffo et al. showed that miR-200 (named miR-8 in miRBase

Open access

Ashley N Reeb, Andrea Ziegler and Reigh-Yi Lin

tumors removed from thyroid cancer patients provide a useful model of thyroid disease mechanisms. Genetically defined cell lines with known driver mutations are particularly useful for clinicians and researchers striving to develop a more personalized

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Giorgio Bedogni, Andrea Mari, Alessandra De Col, Sofia Tamini, Amalia Gastaldelli and Alessandro Sartorio

); (3) availability of oral glucose tolerance test (OGTT); (4) absence of type 1 or type 2 diabetes mellitus. The exclusion criteria were (1) genetic or syndromic obesity; (2) treatment with drugs known to interfere with glucose metabolism. The study was

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Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori and Luigi Brunetti

lack the decline in cognitive ability in the Morris water maze test that is observed in WT mice ( 9 , 10 ). GHRHKO mice represent an animal model of isolated GH deficiency with otherwise normal pituitary function ( 11 ). We have recently demonstrated

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Susanna Cirera, Sophia G Moesgaard, Nora E Zois, Nathja Ravn, Jens P Goetze, Signe E Cremer, Tom Teerlink, Páll S Leifsson, Jesper L Honge, J Michael Hasenkam and Lisbeth H Olsen

experimental animal models. By using large animal models (i.e. pigs), physiologically and genetically closer to humans than rodents, improved understanding of disease and potential testing of new therapeutic and diagnostic approaches ensues (11, 12) . In this

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Natalio García-Honduvilla, Alberto Cifuentes, Miguel A Ortega, Marta Pastor, Garazi Gainza, Eusebio Gainza, Julia Buján and Melchor Álvarez-Mon

described in the literature. In order to model this kind of wounds, the experimental induction of diabetes mellitus with streptozotocin in rodents has been widely used, which causes an impaired wound healing response in the diabetic animals ( 14 , 15

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Janko Sattler, Jinwen Tu, Shihani Stoner, Jingbao Li, Frank Buttgereit, Markus J Seibel, Hong Zhou and Mark S Cooper

-mediated arthritis and their non-inflammatory controls. Methods Mouse models Mice were housed under standard laboratory conditions on a 12:12-h light–darkness cycle with free access to standard chow and water. Animals were kept at the animal facility of

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K E Lines, R P Vas Nunes, M Frost, C J Yates, M Stevenson and R V Thakker

that of the 12–18 months required for development of similar NETs in the conventional models ( 14 , 15 , 16 , 17 ). Thus, our study helps to provide useful refinements in the methodology of animal experiments, as promoted by the National Centre for

Open access

María L Bacigalupo, Verónica G Piazza, Nadia S Cicconi, Pablo Carabias, Andrzej Bartke, Yimin Fang, Ana I Sotelo, Gabriel A Rabinovich, María F Troncoso and Johanna G Miquet

serves as an endocrine factor mediating GH actions in other tissues ( 3 , 4 , 5 ). Evidence from both humans and animal models revealed a link between GH/IGF1 status and cancer risk ( 5 , 6 , 7 , 8 , 9 ). In particular, aberrations in the

Open access

Neil R Chappell, Beth Zhou, Amy K Schutt, William E Gibbons and Chellakkan S Blesson

metabolic components of this model, research on the reproductive system of these animals, in particular the oocyte itself, remains sparse. Prior studies have shown impaired mitochondrial function with hyperandrogenic environments in the oocyte to have