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  • gastric high-grade neuroendocrine neoplasms x
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Qi Zhang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongshan Wang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yanhong Xie Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Suming Huang Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Ke Chen Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Botian Ye Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yupeng Yang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Jie Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongyong He Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Fenglin Liu Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Zhenbin Shen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Weidong Chen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Kuntang Shen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Yihong Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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of gastric neuroendocrine neoplasms (gNENs) ( 12 ). However, Coriat et al. ( 13 ) found that the gastric-originated neoplasms accounted for 8–24% in G3 NET and 7–8% in NEC in several major studies on GEP-NENs. The investigation on gastric high-grade

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0017
Volume/Issue:
Volume 10: Issue 8
Open access
Klaus W Fagerstedt Department of Pathology, University of Helsinki, Helsinki, Finland

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Tom Böhling Department of Pathology, University of Helsinki, Helsinki, Finland
HUH Diagnostic Center and Helsinki University Hospital, Helsinki, Finland

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Harri Sihto Department of Pathology, University of Helsinki, Helsinki, Finland

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Tarja Salonen HUH Diagnostic Center and Helsinki University Hospital, Helsinki, Finland

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Fang Zhao Department of Pathology, University of Helsinki, Helsinki, Finland

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Mia Kero Department of Pathology, University of Helsinki, Helsinki, Finland
HUH Diagnostic Center and Helsinki University Hospital, Helsinki, Finland

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Leif C Andersson Department of Pathology, University of Helsinki, Helsinki, Finland

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Johanna Arola Department of Pathology, University of Helsinki, Helsinki, Finland
HUH Diagnostic Center and Helsinki University Hospital, Helsinki, Finland

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). Tumor cell lines offer versatile tools for studying the molecular biology of neoplasms. Here we describe the establishment and characterization of a spontaneously transformed cell line from a gastric MINEN, composed of high-grade neuroendocrine carcinoma

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0206
Volume/Issue:
Volume 10: Issue 9
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Peiwen Wu Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

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Dongjie He Department of Radiation Oncology, Tangdu Hospital, the Second Affiliated Hospital of Air Force Medical University, Xi’an, China

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Hao Chang Department of Radiation Oncology, Tangdu Hospital, the Second Affiliated Hospital of Air Force Medical University, Xi’an, China

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Xiaozhi Zhang Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

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increased significantly ( Fig. 2B ). Figure 2 Incidence of neuroendocrine tumors from 2000 to 2018. (A) All neuroendocrine tumors and all malignant neoplasms, (B) by sex and race, (C) by stage and grade, (D) by site. NETs, neuroendocrine tumors

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-23-0331
Volume/Issue:
Volume 12: Issue 12
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Matteo Scopel Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Eugenio De Carlo Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Francesca Bergamo Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Sabina Murgioni Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Riccardo Carandina Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy

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Anna Rita Cervino Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Marta Burei Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Federica Vianello Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Vittorina Zagonel Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Matteo Fassan Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Roberto Vettor Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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(92% of total) are invariably low-grade NETs (grading equal to or lower than G2 or typical/atypical carcinoid), on the other hand, in the synchronous group, the low-grade tumors represent only 70% and there is a 13% of high-grade neuroendocrine

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Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0568
Volume/Issue:
Volume 11: Issue 7
Open access
Thomas Couronne Service d’Oncologie Médicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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Paul Girot Service de Gastroentérologie et Oncologie Digestive, Centre Hospitalier Départemental Vendée, La Roche-sur-Yon, France

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Julien Hadoux Service de Médecine Nucléaire et de Cancérologie Endocrinienne, Institut Gustave-Roussy, Villejuif, France

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Thierry Lecomte Service d’Hépato-Gastroentérologie et de Cancérologie Digestive, Centre Hospitalier Régional Universitaire de Tours, Tours, France

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Alice Durand Service d’Oncologie Médicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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Caroline Fine Service d’Oncologie Médicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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Katia Vandevoorde Service d’Oncologie Médicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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Catherine Lombard-Bohas Service d’Oncologie Médicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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Thomas Walter Service d’Oncologie Médicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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. Gastroenteropancreatic high-grade neuroendocrine carcinoma . Cancer 2014 120 2814 – 2823 . ( https://doi.org/10.1002/cncr.28721 ) 5 Garcia-Carbonero R Sorbye H Baudin E Raymond E Wiedenmann B Niederle B Sedlackova E Toumpanakis C Anlauf M

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0192
Volume/Issue:
Volume 9: Issue 6
Open access
Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK

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Omar Faiz Department of Surgery, St Mark’s Hospital, London, UK

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Robert Goldin Centre for Pathology, Imperial College London, London, UK

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John Martin Department of Gastroenterology, Imperial College London, London, UK

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Harpreet Wasan Department of Surgery and Cancer, Imperial College London, London, UK

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Marc-Olaf Liedke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Erik Schloericke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Anna Malczewska Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Guido Rindi Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Irvin M Modlin Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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stage have been developed for SB NET, namely the World Health Organisation (WHO)/European Neuroendocrine Tumor Society (ENETS) staging and grading system ( 15 ) and the American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0114
Volume/Issue:
Volume 6: Issue 2
Open access
Mark J C van Treijen Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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Catharina M Korse Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wieke H Verbeek Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Margot E T Tesselaar Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Gerlof D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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for gastric neuroendocrine neoplasms . Journal of Cancer 2019 10 5944 – 5954 . ( https://doi.org/10.7150/jca.35785 ) 8 Modlin IM Gustafsson BI Pavel M Svejda B Lawrence B Kidd M . A nomogram to assess small-intestinal neuroendocrine

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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0146
Volume/Issue:
Volume 11: Issue 10
Open access
Wentao Zhou The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Tiantao Kuang The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xu Han Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenqi Chen Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xuefeng Xu The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenhui Lou Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Dansong Wang The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Introduction Pancreatic neuroendocrine neoplasm (pNEN) is a rare malignancy arising from pancreatic islet cells and accounts for 1–2% of all pancreatic tumors ( 1 ). However, with the popularization of abdominal imaging and the promotion of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0541
Volume/Issue:
Volume 9: Issue 4
Open access
Carole Morin Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Keo-Morakort Benedetto Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Agathe Deville Hospices Civils de Lyon, Hôpital Louis Pradel, Médecine Nucléaire, Bron, France
Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France

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Laurent Milot Hospices Civils de Lyon, Hôpital Edouard Herriot, Radiologie, Lyon Cedex 03, France
University of Lyon, Université Lyon 1, France

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Aurélie Theillaumas Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Valérie Hervieu Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France
University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Institut de Pathologie Est, Bron Cedex, France

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Mathieu Pioche University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Edouard Herriot, Gastroentérologie, Lyon Cedex 03, France

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Gilles Poncet Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France
University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Edouard Herriot, Chirurgie Digestive, Lyon Cedex 03, France

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Julien Forestier Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Laurent François Hospices Civils de Lyon, Hôpital Louis Pradel, Exploration Fonctionnelle, Bron Cedex, France

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Francoise Borson-Chazot University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Louis Pradel, Endocrinologie, Bron Cedex, France

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Mustapha Adham University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Edouard Herriot, Chirurgie Digestive, Lyon Cedex 03, France

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Catherine Lombard-Bohas Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Thomas Walter Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France
Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France
University of Lyon, Université Lyon 1, France

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Introduction Neuroendocrine neoplasm (NEN) is a rare disease, though its incidence is rising ( 1 , 2 ). NENs are heterogeneous diseases regarding the number of primary origins, clinical presentation, staging, grading, and prognosis. Their

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Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0097
Volume/Issue:
Volume 11: Issue 6
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Linfei Yang Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China

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Xiao Yu Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China

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Yongchao Yang Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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test was used for statistics analysis. ★ P  < 0.001 vs NC. ATX, autotaxin; NC, normal control; pNEN, pancreatic neuroendocrine neoplasms. ATX expression levels are significantly correlated with tumour grade, lymph node metastasis and TNM

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0356
Volume/Issue:
Volume 7: Issue 12
Open access