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Ingeborg Brønstad Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Lars Breivik Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Paal Methlie Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Anette S B Wolff Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Eirik Bratland Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Ingrid Nermoen Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Kristian Løvås Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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Eystein S Husebye Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway

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the sequences of B. taurus and S. scrofa 21OH ( Fig. 2 ), and was predicted as harmless ( Table 3 ), again in line with a normal enzyme activity. Discussion In the present study, we introduced a novel method for functional studies of CYP21A2

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Gamze Akkuş Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey

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Isa Burak Güney Nuclear Medicine Department, Cukurova University Medical Faculty, Adana, Turkey

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Fesih Ok Urology Department, Cukurova University Medical Faculty, Adana, Turkey

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Mehtap Evran Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey

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Volkan Izol Urology Department, Cukurova University Medical Faculty, Adana, Turkey

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Şeyda Erdoğan Pathology Department, Cukurova University Medical Faculty, Adana, Turkey

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Yıldırım Bayazıt Urology Department, Cukurova University Medical Faculty, Adana, Turkey

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Murat Sert Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey

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Tamer Tetiker Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey

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do not separate the functional adenomas from the non-functional adenomas. 18 F-FDG positron emission CT was originally developed to evaluate benign and malignant lesions. However, there were limited studies on the usage in determining the

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Xingyao Tang Beijing Tongren Hospital, Capital Medical University

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Zhi-Hui Song Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Dawei Wang General Practice Department, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Jinkui Yang Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Marly Augusto Cardoso Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil

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Jian-Bo Zhou Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Rafael Simó Endocrinology and Nutrition Department, Hospital Universitari Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

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.neurobiolaging.2007.07.019 ) 28 Formiga F Ferrer A Padros G Contra A Corbella X Pujol R Octabaix Study Group. Thyroid status and functional and cognitive status at baseline and survival after 3 years of follow-up: the OCTABAIX study . European Journal

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Antonina Khoruzhenko Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium
Institute of Molecular Biology and Genetics, NAS of Ukraine, Kiev, Ukraine

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Françoise Miot Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium

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Claude Massart Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium

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Jacqueline Van Sande Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium

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Jacques Emile Dumont Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles, Brussels, Belgium

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Renaud Beauwens Laboratory of Physiology and Pharmacology, Université libre de Bruxelles, Brussels, Belgium

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Alain Boom Laboratoire d’Histologie, de Neuroanatomie et de Neuropathologie, Université libre de Bruxelles, Brussels, Belgium

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Introduction Thyroid cell cultures are widely used to study the basic mechanisms of the gland function, as well as to investigate the processes of carcinogenesis, sensitivity to drugs, toxicological studies, and others. The functional activity

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Marianna Viukari Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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Helena Leijon Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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Tiina Vesterinen Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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Sanni Söderlund Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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Päivi Hämäläinen Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

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Iina Yliaska Medical Research Center Oulu, Oulu University Hospital and Research Unit of Internal Medicine, University of Oulu, Oulu, Finland

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Päivi Rautiainen Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Joensuu, Finland

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Reeta Rintamäki Department of Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland

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Minna Soinio Department of Endocrinology, Turku University Hospital, Turku, Finland

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Ilkka Pörsti Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

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Pasi I Nevalainen Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

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Niina Matikainen Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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> 3 and <4. Functional imaging with radioisotopes All 11 C-MTO-PET studies were performed in Turku PET center without dexamethasone pretreatment as previously described ( 18 ). The scans were analyzed by an expert in nuclear medicine, although

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Weiwei He School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Caoxin Huang Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Xiulin Shi Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China

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Menghua Wu School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Han Li School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Qiuhong Liu School of Medicine, Xiamen University, Xiamen, China
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Xiaofang Zhang Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Yan Zhao Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China

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Xuejun Li Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, China
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Prevention and Treatment Center, Xiamen, China

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progression, we also performed GSEA using data from our previous study ( 28 ). Weighted gene co-expression network analysis To further clarify the possible functional pathways related to the enrichment of signature gene sets, weighted gene co

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R A M Quax Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J A M van Laar Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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R van Heerebeek Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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K Greiner Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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E Ben-Chetrit Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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M Stanford Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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G R Wallace Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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F Fortune Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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M Ghabra Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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M Soylu Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J M W Hazes Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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S W J Lamberts Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J H Kappen Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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P M van Hagen Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J W Koper Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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R A Feelders Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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polymorphism) were participants in the Rotterdam Study, a population-based prospective cohort study on determinants of disease and disability in persons, aged 55 years and older, living in Rotterdam, The Netherlands. To study functional differences in in vitro

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Wenrui Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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Chuan Zhang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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and transdifferentiation, as well as the highlights of exciting new research. Optimized protocols to augment functional mature β-cells will guide future precision medicine studies of improved treatment strategies for patients with DM and may even

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Shan Wu College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China
Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

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Jianjun Zhou Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

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Jing Guo Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China

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Zhan Hua Department of General Surgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China

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Jianchen Li College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China

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Zai Wang Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China

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In this study, we generated insulinoma and non-functional PNET preclinical models based on INR1G9 and INS-1 cells and compared the antitumor efficacy of apatinib with that of sunitinib in these models. Currently, PNET preclinical models are scarce

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Hanbaro Kim Department of Surgery, Hallym University College of Medicine, Chuncheon, Republic of Korea

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Ki Byung Song Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Dae Wook Hwang Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Jae Hoon Lee Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Shadi Alshammary Department of Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

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Song Cheol Kim Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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PNETs has been steadily increasing, possibly as a result of increased detection on endoscopic and cross-sectional imaging studies ( 3 , 4 ). PNETs are functional or non-functional tumors and represent a heterogeneous group of neoplasms with extremely

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