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  • free 25-hydroxyvitamin D x
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Shatha Alharazy Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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M Denise Robertson Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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Susan Lanham-New Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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Muhammad Imran Naseer Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

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Adeel G Chaudhary Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Centre for Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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Eman Alissa Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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.41) *Significant correlation ( P < 0.05). 25(OH)D, 25-hydroxyvitamin D; BMI, body mass index; Ca, calcium; PO 4 , phosphate; PTH is parathyroid hormone. Total 25(OH)D and free 25(OH)D associations with skin tone, veiling type, parity, and sun

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0445
Volume/Issue:
Volume 10: Issue 12
Open access
Johanna Öberg Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway

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Rolf Jorde Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway

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Yngve Figenschau Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway

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Per Medbøe Thorsby Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway

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Sandra Rinne Dahl Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway

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Anne Winther Division of Neurosciences, Orthopedics and Rehabilitation Services, University Hospital of North Norway, Tromso, Norway

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Guri Grimnes Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway

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+, combined hormonal contraceptive users; DBP, vitamin D-binding protein; free 25(OH)D , measured free 25(OH)D; FGF23, fibroblast growth factor; PTH, parathyroid hormone; VMR, 24,25(OH) 2 D/25(OH)D vitamin D metabolite ratio; 2325(OH)D, 25-hydroxyvitamin D; 1,25

Article Type:
Research Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-21-0395
Volume/Issue:
Volume 11: Issue 3
Open access
Göran Oleröd Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Lillemor Mattsson Hultén Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ola Hammarsten Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Eva Klingberg Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Kowalski MA Ryzen E Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein . Journal of Clinical Endocrinology and Metabolism 1986 63 954 – 959 . ( doi:10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0078
Volume/Issue:
Volume 6: Issue 2
Open access
Niek F Dirks Atalmedial Diagnostics Centre, Spaarne Gasthuis, Haarlem, The Netherlands
Department of Clinical Chemistry, Hematology and Immunology, Noordwest Ziekenhuis, Alkmaar, The Netherlands

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Etienne Cavalier Department of Clinical Chemistry, University of Liège, CHU de Liège, Liège, Belgium

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Annemieke C Heijboer Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Boelelaan, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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-hydroxyvitamin D Over 85% of 25(OH)D and 1,25(OH) 2 D is bound to VDBP, while most of the remaining are bound to albumin and only about 0.03% circulates free of any binding protein ( 21 ). Some have suggested that calculated bioavailable 25(OH)D (not bound to

Article Type:
Review Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-22-0269
Volume/Issue:
Volume 12: Issue 4
Open access
J A Tamblyn Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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C Jenkinson Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK

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D P Larner Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK

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M Hewison Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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M D Kilby Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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major site for vitamin D metabolism, expressing the 25-hydroxyvitamin D3 1α-hydroxylase (1α-hydroxylase) enzyme that synthesises 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D3) from precursor 25-hydroxyvitamin D3 (25(OH)D3), as well as 25-hydroxyvitamin D-24

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0308
Volume/Issue:
Volume 7: Issue 1
Open access
Jane Fletcher Nutrition Nurses, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, UK
School of Nursing, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK

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Emma L Bishop Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK

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Stephanie R Harrison Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK

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Amelia Swift School of Nursing, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK

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Sheldon C Cooper Gastroenterology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, UK

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Sarah K Dimeloe Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK

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Karim Raza Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK

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Martin Hewison Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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outlined in Fig. 1 , the physiological actions of vitamin D metabolites are dependent on further metabolic steps ( 1 ). The first occurs in the liver via the enzyme vitamin D-25-hydroxylase (25-OHase) to generate 25-hydroxyvitamin D (25D). While this is

Article Type:
Review Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-21-0554
Volume/Issue:
Volume 11: Issue 3
Open access
Zhen-yu Song Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Qiuming Yao Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Zhiyuan Zhuo Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Zhe Ma Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Gang Chen Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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useful treatment measures are urgently needed by people to improve the survival rate of prostate cancer patients. The major circulating form of vitamin D in human body is 25-hydroxyvitamin D (25(OH)D), which comes from vitamin D via 25-hydroxylation

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0283
Volume/Issue:
Volume 7: Issue 12
Open access
Barbara J Boucher Blizard Institute, Barts & The London school of Medicine & Dentistry, Queen Mary University of London, London, UK

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analyses. Free vs bound 25-hydroxyvitamin D Most 25(OH)D in the circulation is bound to the binding proteins already mentioned but small amounts remain unbound or ‘free’. The relative importance of unbound versus bound 25(OH)D uptake by different

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0274
Volume/Issue:
Volume 9: Issue 9
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Behnaz Abiri Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Majid Valizadeh Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Amirhossein Ramezani Ahmadi Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

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Shirin Amini Department of Nutrition, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran

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Mohammad Nikoohemmat Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Faeze Abbaspour Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Farhad Hosseinpanah Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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2021 75 e14718 . ( https://doi.org/10.1111/ijcp.14718 ) 50 Saarnio E Pekkinen M Itkonen ST Kemi V Karp H Ivaska KK Risteli J Koivula MK Kärkkäinen M Mäkitie O , et al. Low free 25-hydroxyvitamin D and high vitamin D binding

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Research Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-23-0394
Volume/Issue:
Volume 13: Issue 2
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Stefan Pilz Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Armin Zittermann Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr University Bochum, Bad Oeynhausen, Germany

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Christian Trummer Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Verena Theiler-Schwetz Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Elisabeth Lerchbaum Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Martin H Keppel University Institute for Medical and Chemical Laboratory Diagnostics, Paracelsus Medical University, Salzburg, Austria

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Martin R Grübler Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, University of Bern, Bern, Switzerland

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Winfried März Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Ruperto-Carola University of Heidelberg, Heidelberg, Germany
Synlab Medical Center of Human Genetics Mannheim, Mannheim, Germany

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Marlene Pandis Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Lerchbaum E Pieber TR Obermayer-Pietsch B Wilhelm M Hahn A , et al . Hormonal contraceptive use is associated With higher total but unaltered free 25-hydroxyvitamin D serum concentrations . Journal of Clinical Endocrinology and Metabolism 2018 103

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0432
Volume/Issue:
Volume 8: Issue 2
Open access