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Jing Hong, Wen-Yue Liu, Xiang Hu, Fei-Fei Jiang, Ze-Ru Xu, Fang Li, Fei-Xia Shen, and Hong Zhu

). About 49% of patients with DM and foot ulcers (DFUs) have coexisting peripheral artery disease (PAD) ( 3 ), which is usually asymptomatic. For these patients, the coexisting sensory neuropathy may mask the symptoms of intermittent claudication and

Open access

A H Ludwig-Slomczynska, S Borys, M T Seweryn, J Hohendorff, P Kapusta, B Kiec-Wilk, E Pitera, P P Wolkow, and M T Malecki

Introduction Diabetic foot syndrome (DFS) is characterized as an infection, ulceration, or destruction of deep tissues of the foot associated with neuropathy and/or peripheral arterial disease ( 1 ). Diabetic foot ulcer (DFU) is a frequently

Open access

Natalio García-Honduvilla, Alberto Cifuentes, Miguel A Ortega, Marta Pastor, Garazi Gainza, Eusebio Gainza, Julia Buján, and Melchor Álvarez-Mon

estimated to have diagnosed or undiagnosed diabetes ( 5 ). The lifetime risk of a foot ulcer in patients with diabetes may be as high as 25 percent ( 6 ). Diabetic foot ulcers are a major cause of morbidity and mortality, accounting for approximately two

Open access

Shufei Zang, Lei Shi, Jinying Zhao, Min Yang, Jun Liu, and Heyuan Ding

morbidity and mortality, which increases the financial burden of T2DM treatment ( 5 , 6 ). Furthermore, DPN is responsible for the development of various serious diseases, such as foot ulcer, infection, gangrene and non-traumatic lower limb amputation

Open access

Eva O Melin, Jonatan Dereke, Maria Thunander, and Magnus Hillman

heart disease, cardiac failure, stroke or transient ischemic attack. Foot complications These were defined as neuropathy, angiopathy, earlier or present diabetes foot ulcer, foot infection, foot deformity, arthropathy or amputation of the lower

Open access

Fang Lv, Xiaoling Cai, Chu Lin, Tianpei Hong, Xiaomei Zhang, Zhufeng Wang, Huifang Xing, Guizhi Zong, Juming Lu, Xiaohui Guo, Jing Wu, Leili Gao, Xianghai Zhou, Xueyao Han, and Linong Ji

completely or incompletely recovered. Cardiovascular disease was defined as having either coronary heart disease or stroke. Peripheral vascular disease was defined as intermittent claudication, foot ulcer, or amputation. Nephropathy was defined as the

Open access

Trevor Lewis, Eva Zeisig, and Jamie E Gaida

glucose levels such as is seen in insulin resistance and type 2 diabetes ( 74 ). The mechanical properties of Achilles tendons obtained following amputations for non-healing diabetic ulcers were compared with Achilles tendons obtained following amputations