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Lauren E Henke, John D Pfeifer, Thomas J Baranski, Todd DeWees and Perry W Grigsby

pathologic markers, such as histologic subtype or somatic mutation profile, which might stratify patients at risk for these poor long-term outcomes. The majority of PTC cases comprise two histologic subtypes: classic papillary (CP) and follicular variant

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Ana P Estrada-Flórez, Mabel E Bohórquez, Alejandro Vélez, Carlos S Duque, Jorge H Donado, Gilbert Mateus, Cesar Panqueba-Tarazona, Guadalupe Polanco-Echeverry, Ruta Sahasrabudhe, Magdalena Echeverry and Luis G Carvajal-Carmona

cities. A total of 149 incident and histologically verified PTC patients, 81 with classical variant PTC (CVPTC) and 68 with follicular variant PTC (FVPTC), were recruited in between 2006 and 2016. All patients provided written informed consent, were

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Barbora Pekova, Sarka Dvorakova, Vlasta Sykorova, Gabriela Vacinova, Eliska Vaclavikova, Jitka Moravcova, Rami Katra, Petr Vlcek, Pavla Sykorova, Daniela Kodetova, Josef Vcelak and Bela Bendlova

in many different types of cancer, including PTC. Several variants have been revealed in the conserved part of the IDH1 gene with an association with follicular variant of PTC ( 14 ). In the EZH1 gene a hotspot Q571R mutation was detected that

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Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

lack of data of TCVPTC and PTC-TCF, (ii) studies including different variants (e.g., follicular variant) other than classical variant in the control group, (iii) datasets considered as overlapping or duplicated, (iv) reviews, (v) case reports and (vi

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Dario de Biase, Federica Torricelli, Moira Ragazzi, Benedetta Donati, Elisabetta Kuhn, Michela Visani, Giorgia Acquaviva, Annalisa Pession, Giovanni Tallini, Simonetta Piana and Alessia Ciarrocchi

subgroup ( Table 1 ). Lung was the most frequent metastatic site (54.1%, data not shown). Of 151 cases, 88 were diagnosed as ‘classic-PTC’ (C-PTC, 58.3%), 25 as ‘Tall-cell Variant-PTC’ (TCV-PTC, 16.6%), 17 as ‘Follicular Variant-PTC’ (FV-PTC, 11.3%), 3 as

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Klaudia Zajkowska, Janusz Kopczyński, Stanisław Góźdź and Aldona Kowalska

Introduction The follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common histological variant of papillary thyroid carcinoma (PTC) ( 1 ). There are two variants of FVPTC, non-encapsulated (infiltrative) and

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Ana Carolina de Jesus Paniza, Thais Biude Mendes, Matheus Duarte Borges Viana, Débora Mota Dias Thomaz, Paula B O Chiappini, Gabriel A Colozza-Gama, Susan Chow Lindsey, Marcos Brasilino de Carvalho, Venâncio Avancini Ferreira Alves, Otavio Curioni, André Uchimura Bastos and Janete Maria Cerutti

thyroid carcinoma (PTC), the increase can also be partially ascribed to the evolution of histological criteria for the diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC) ( 1 , 2 , 3 , 4 , 5 , 6 ). This variant is composed

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Guoquan Zhu, Yuying Deng, Liqin Pan, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang, Yanying Chen and Jiaxin Luo

was 38.6 ± 12.4 years (range 5–76 years); 68.0% (830) of patients were female and 32.0% (390) were male. The histologic cancer types included 1168 (95.7%) classic PTCs, 36 (3.0%) follicular variant PTCs and 16 (1.3%) other aggressive PTC variants

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Simonetta Piana, Eleonora Zanetti, Alessandra Bisagni, Alessia Ciarrocchi, Davide Giordano, Federica Torricelli, Teresa Rossi and Moira Ragazzi

histotype NOTCH1 was detected primarily in the cytoplasm. Figure 3 Pattern of NOTCH1 positivity in PTC classic type (A and B), tall cell variant (C) and follicular variant (D). (A and B) Magnification 40×, (C and D) 100×. Scale bar 100 µm

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Joana Simões-Pereira, Daniel Macedo and Maria João Bugalho

Histological characteristics and staging. Characteristics Number of patients (percentage) Histological type • PTC 15 (55.6%)  Classical variant 6 (22.2%)  Follicular variant 4 (14.8%)  Macrofollicular