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Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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Introduction Chemical flame retardants (FRs) are commonly applied to foam-based furniture and infant products to meet commercial flammability standards. Many FRs are additive rather than reactive, and therefore able to migrate, resulting in
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perchlorate, phenols, pesticides, polychlorinated biphenyls (PCBs), poly brominated flame retardants, perfluorinated compounds (PFCs) and phthalates ( Fig. 1 ). Many of these substances are classed as persistent organic pollutants (POPs) and were banned
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Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
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mice: reproductive toxicity and intergenerational transmission . Toxicological Sciences 2012 126 213 – 226 . ( doi:10.1093/toxsci/kfr327 ). 9 Darnerud PO . Brominated flame retardants as possible endocrine disrupters . International Journal
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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-called endocrine disruptors may have estrogen activity or may cause an increase of endogenous estrogen secretion ( 46 , 47 , 48 ). Flame retardants have been widely used in the last decades to reduce flammability of electronic devices. Their effect as endocrine
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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generations, referred to as ‘generational toxicology’ ( 104 ). Obesogens, old and new A variety of chemicals have been demonstrated to be obesogenic in animal studies. These include such widely used chemicals as phthalates, bisphenols, parabens, flame