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Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi, Donatella Caruso, Guido Cavaletti, and Manuela Simoni

Introduction Finasteride is an inhibitor of 5 alpha-reductase (5α-R) type 1 and 2 enzymes, encoded by the SRD5A1 and SRD5A2 gene, respectively, with higher affinity for 5α-R type 2 in the human ( 1 , 2 ). This enzyme converts testosterone

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L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran, and N F Taylor

order to seek to identify which 5α-reductase isoform was being targeted by mitotane, we also made comparisons with steroid excretion in patients with 5α-reductase 2 deficiency (5ARD2) and those receiving the 5α-reductase inhibitors finasteride or

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Michael Ulm, Arvind V Ramesh, Keely M McNamara, Suriyan Ponnusamy, Hironobu Sasano, and Ramesh Narayanan

precursors such as androstenedione and androstenediol by the enzyme 5α-reductase ( 15 ). Finasteride and dutasteride are the two approved 5α-reductase inhibitors used for the prevention of PCa. Three isoforms of 5α-reductase have been discovered. While

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Alexander Tacey, Lewan Parker, Bu B Yeap, John Joseph, Ee M Lim, Andrew Garnham, David L Hare, Tara Brennan-Speranza, and Itamar Levinger

2005 90 678 – 688 . ( https://doi.org/10.1210/jc.2004-1184 ) 10.1210/jc.2004-1184 41 Page ST Amory JK Bowman FD Anawalt BD Matsumoto AM Bremner WJ Tenover JL. Exogenous testosterone (T) alone or with finasteride increases physical performance

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Lina S Silva-Bermudez, Freddy J K Toloza, Maria C Perez-Matos, Russell J de Souza, Laura Banfield, Andrea Vargas-Villanueva, and Carlos O Mendivil

prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism . Journal of Clinical Endocrinology and Metabolism 1999 84 1304 – 1310 . ( https://doi.org/10