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invasion extrathyroidal extension and CCLNM in cN0 PTC. (A) Multifocality; (B) capsular invasion; (C) extrathyroidal extension. Capsular invasion The data from six included studies was assessed using a random-effects model ( P = 0.04, I 2
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, year of publication, time of operation, criteria for TCVPTC/PTC-TCF, multifocality, extrathyroidal extension, lymph node metastasis, pathological T factor of the TNM staging system (pT factor), distant metastasis at time of presentation, tumor
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location, extrathyroidal extension, capsular invasion), pathological characteristics of LNM (stage, number, size of the largest metastatic focus of LNM, extranodal extension), distant metastases, the BRAF V600E status in primary tumor and in LNM, the 131 I
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Conventional 97.0% (32) 94.4% (68) 95.8% (68) NS NS Follicular 0% (0) 4.2% (3) 4.2% (3) Macrofollicular 0% (0) 1.4% (1) 0% (0) Oncocytic 3.0% (1) 0% (0) 0% (0) Extrathyroidal extension 9.1% (3) 31
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.1 and 3.7 GBq were equivalent in terms of ablation success rate ( 6 , 9 ). These studies have led to a change in UK practice over time because they have demonstrated how to minimise radiation exposure and the risk of potential side effects or
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median had a significantly higher risk of T stage 3/4, LNM, lateral LNM, stage III/IV, and extrathyroidal extension (ETE) ( 15 ). Conversely, a study in 2022 revealed that low serum vitamin D levels were not associated with the aggressive pathological
Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland
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, with extrathyroidal extension, massive nodal involvement or in case of airways compression. However, according to the authors of ATA guidelines, the qualification for radiotherapy has to be cautious due to a risk of acute and late complications ( 6
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fluid over time, and effects of thyroid nodule fine needle aspiration (FNA) or radiofrequency ablation, and the nodules may become dry, shrunken, and solid. Lacout et al. referred to these as mummified TNs (MTNs) ( 8 ). According to ACR-TIRADS, MTNs
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such as male sex, advanced age, tumor size, extrathyroidal extension of the neoplasm, and incomplete surgical resection can negatively affect the prognosis ( 9 ). An important aspect of understanding neoplastic aggressiveness is the assessment of the
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features, including extrathyroidal extension, lymph node metastases (LNM), advanced stage, and poor clinical outcomes. In a meta-analysis of 19 studies on clinicopathologic features of papillary thyroid microcarcinoma (PTMC) with information on BRAF