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Wei Sun Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China

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Boyuan Zheng Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China

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Zhihong Wang Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China

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Wenwu Dong Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China

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Yuan Qin Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China

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Hao Zhang Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China

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invasion extrathyroidal extension and CCLNM in cN0 PTC. (A) Multifocality; (B) capsular invasion; (C) extrathyroidal extension. Capsular invasion The data from six included studies was assessed using a random-effects model ( P  = 0.04, I 2

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Huy Gia Vuong Department of Pathology, University of Yamanashi, Yamanashi, Japan

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Nguyen Phuoc Long Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam

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Nguyen Hoang Anh School of Medicine, Viet Nam National University, Ho Chi Minh City, Viet Nam

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Tran Diem Nghi School of Medicine, Viet Nam National University, Ho Chi Minh City, Viet Nam

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Mai Van Hieu School of Medicine, Viet Nam National University, Ho Chi Minh City, Viet Nam

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Le Phi Hung Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam

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Tadao Nakazawa Department of Pathology, University of Yamanashi, Yamanashi, Japan

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Ryohei Katoh Department of Pathology, University of Yamanashi, Yamanashi, Japan

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Tetsuo Kondo Department of Pathology, University of Yamanashi, Yamanashi, Japan

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, year of publication, time of operation, criteria for TCVPTC/PTC-TCF, multifocality, extrathyroidal extension, lymph node metastasis, pathological T factor of the TNM staging system (pT factor), distant metastasis at time of presentation, tumor

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Pan Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Liqin Pan Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wensi Huang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Huijuan Feng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wei Ouyang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Juqing Wu Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jing Wang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yuying Deng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jiaxin Luo Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yanying Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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location, extrathyroidal extension, capsular invasion), pathological characteristics of LNM (stage, number, size of the largest metastatic focus of LNM, extranodal extension), distant metastases, the BRAF V600E status in primary tumor and in LNM, the 131 I

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Ayana Suzuki Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan

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Mitsuyoshi Hirokawa Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan

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Izumi Otsuka Secretary Section, Kuma Hospital, Kobe, Japan

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Akihiro Miya Department of Surgery, Kuma Hospital, Kobe, Japan

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Akira Miyauchi Department of Surgery, Kuma Hospital, Kobe, Japan

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Takashi Akamizu Department of Internal Medicine, Kuma Hospital, Kobe, Japan

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 Conventional 97.0% (32) 94.4% (68) 95.8% (68) NS NS  Follicular 0% (0) 4.2% (3) 4.2% (3)  Macrofollicular 0% (0) 1.4% (1) 0% (0)  Oncocytic 3.0% (1) 0% (0) 0% (0)  Extrathyroidal extension 9.1% (3) 31

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Eugenie S Lim Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Shanty G Shah Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Mona Waterhouse Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Scott Akker Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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William Drake Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Nick Plowman Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Daniel M Berney Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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Polly Richards Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Ashok Adams Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Ewa Nowosinska Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Carmel Brennan Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK

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Maralyn Druce Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK

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.1 and 3.7 GBq were equivalent in terms of ablation success rate ( 6 , 9 ). These studies have led to a change in UK practice over time because they have demonstrated how to minimise radiation exposure and the risk of potential side effects or

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Yuting Shao Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Xiaole Hu Department of Operating Room, Qilu Hospital of Shandong University, Shandong, China

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Yuxi Wang Department of Breast and Thyroid Surgery, People’s Hospital of Mengyin County, Linyi, Shandong, China

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Yi Shao Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Luchuan Li Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Qingdong Zeng Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Hong Lai Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Lei Sheng Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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median had a significantly higher risk of T stage 3/4, LNM, lateral LNM, stage III/IV, and extrathyroidal extension (ETE) ( 15 ). Conversely, a study in 2022 revealed that low serum vitamin D levels were not associated with the aggressive pathological

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Aleksandra Kukulska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland
Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Jolanta Krajewska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Zofia Kolosza Department of Epidemiology and Silesia Cancer Registry, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Ewa Paliczka-Cieslik Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Aleksandra Kropinska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Agnieszka Pawlaczek Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Zbigniew Puch Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Kornelia Ficek Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Teresa Lisik Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Dorota Sygula Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Zbigniew Wygoda Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Jozef Roskosz Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Jerzy Wydmanski Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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Barbara Jarzab Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

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, with extrathyroidal extension, massive nodal involvement or in case of airways compression. However, according to the authors of ATA guidelines, the qualification for radiotherapy has to be cautious due to a risk of acute and late complications ( 6

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Jiali Tian Ultrasound Department, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China

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Jinlei Liang Ultrasound Department, Zhuhai People's Hospital, Zhuhai, China

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Yuhong Lin Ultrasound Department, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China

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Liping Wang Ultrasound Department, Zhuhai Xiangzhou District People's Hospital, Zhuhai, China

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Xiaobo Chen Ultrasound Department, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China

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fluid over time, and effects of thyroid nodule fine needle aspiration (FNA) or radiofrequency ablation, and the nodules may become dry, shrunken, and solid. Lacout et al. referred to these as mummified TNs (MTNs) ( 8 ). According to ACR-TIRADS, MTNs

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Camila Aparecida Moma Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Icléia Siqueira Barreto Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Ligia Vera Montali Assumpção Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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Denise Engelbrecht Zantut-Wittmann Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

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such as male sex, advanced age, tumor size, extrathyroidal extension of the neoplasm, and incomplete surgical resection can negatively affect the prognosis ( 9 ). An important aspect of understanding neoplastic aggressiveness is the assessment of the

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Sara Ahmadi Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Iñigo Landa Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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features, including extrathyroidal extension, lymph node metastases (LNM), advanced stage, and poor clinical outcomes. In a meta-analysis of 19 studies on clinicopathologic features of papillary thyroid microcarcinoma (PTMC) with information on BRAF

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