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Dirk-Jan van Beek, Rachel S van Leeuwaarde, Carolina R C Pieterman, Menno R Vriens, Gerlof D Valk and the DutchMEN Study Group

by indication ( 8 , 9 ). Confronted by the principles of evidence-based medicine and need for high-quality scientific evidence regarding follow-up and interventions in MEN1, in the Netherlands in 2007, a retrospective MEN1 database was carefully

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Raymond J Rodgers, Jodie C Avery, Vivienne M Moore, Michael J Davies, Ricardo Azziz, Elisabet Stener-Victorin, Lisa J Moran, Sarah A Robertson, Nigel K Stepto, Robert J Norman and Helena J Teede

disorder that affects more than one in ten women, significantly impacting health and well-being ( 2 , 3 ). The pathophysiology of PCOS is poorly understood and a US National Institute of Health (NIH) evidence-based consensus workshop has recognised that

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Suvanjaa Sivalingam, Marianne Thvilum, Thomas Heiberg Brix, Laszlo Hegedüs and Frans Brandt

surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland . Journal of Internal Medicine 1991 229 415 – 420 . ( ) 6 Brix TH Kyvik KO Christensen K Hegedüs L. Evidence for a

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Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

, increasing evidence has demonstrated the beneficial effects of GLP-1 on β cell function because GLP-1 has been shown to improve β cell function and survival in vitro and in several rodent models of diabetes ( 33 ). Therefore, incretin-based treatment offers

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Yongli Fu, Yaowu Sun, Jiankun Zhang and Yu Cheng

Introduction The past two decades have witnessed great progress on the research regarding optimal glycemic control strategy for critically ill patients based on several randomized controlled trials (RCTs). However, there are still debates on

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J Chycki, A Zajac, M Michalczyk, A Maszczyk and J Langfort

have been obtained during steady-state endurance exercises. However, there remains a paucity of evidence on how continuous running with low, moderate, or high intensity during a single continuous bout of exercise affect plasma hormonal and metabolic

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Willem de Ronde and Diederik L Smit

steroids for performance or image enhancing purposes. Managing health problems in active users asks for a strategy of harm reduction. The problem is that the harms for the individual patient are hard to predict and there are no evidence-based harm

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Trevor Lewis, Eva Zeisig and Jamie E Gaida

with elevated cortisol levels ( 92 ). Whilst there is an established evidence base for the link between metabolic disorders and tendon problems in patients with Cushing’s syndrome, there are no data on cortisol levels in tendinopathy. This is

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Antonia Ertelt, Ann-Kristin Barton, Robert R Schmitz and Heidrun Gehlen

equines. Pathophysiology of metabolic syndrome Multiple hypotheses regarding the pathogenesis of metabolic syndrome exist in human and equine medicine. Some of them can be supported by evidence, while others require further research. One of these

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Nella Augusta Greggio, Elisa Rossi, Silvia Calabria, Alice Meneghin, Joaquin Gutierrez de Rubalcava, Carlo Piccinni and Antonella Pedrini

Survey (NHANES III), the largest community-based study on thyroid function conducted in the United States, found that 4.6% of patients had hypothyroidism, out of these 4.3% was affected by a subclinical form of the disease ( 3 ). To date, data regarding