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Open access

Ghrelin- and GH-induced insulin resistance: no association with retinol-binding protein-4

Esben Thyssen Vestergaard, Morten B Krag, Morten M Poulsen, Steen B Pedersen, Niels Moller, Jens Otto Lunde Jorgensen, and Niels Jessen

hyperinsulinemic–euglycemic clamp (plasma glucose clamped at 5.0 mmol/l, insulin 0.6 mU/kg per min, Actrapid, Novo Nordisk, Copenhagen, Denmark) was performed from t =120 to t =300 min. The period from t =0 to t =120 min is referred to as the basal period and

Open access

Efficacy of increased resistant starch consumption in human type 2 diabetes

C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby, and M D Robertson

period, participants completed a 7-day food and drink diary and a 7-day bowel habit and symptom diary. Participants attended for three study visits at the end of each intervention: i) a two-step euglycemic–hyperinsulinemic clamp combined with an infusion

Open access

4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo

Sandra Pereira, Jessy Moore, Jia-Xu Li, Wen Qin Yu, Husam Ghanim, Filip Vlavcheski, Yemisi Deborah Joseph, Paresh Dandona, Allen Volchuk, Carolyn L Cummins, Evangelia Tsiani, and Adria Giacca

infusion study and an infusion study followed by a hyperinsulinemic-euglycemic clamp. An overnight fast was started on the second experiment day for both types of studies. In the basal infusion study, the treatment was infused for 48 h and this was followed

Open access

Macrophage activation marker sCD163 correlates with accelerated lipolysis following LPS exposure: a human-randomised clinical trial

Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller, and Henning Grønbæk

followed by a two-hour hyperinsulinemic euglycemic clamp period. Ethics The Danish Ethical Committee approved the study (1-10-71-410-12) and registered at (Nbib1705782). Both written and oral consents were obtained before

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Changes in adipose tissue lipolysis gene expression and insulin sensitivity after weight loss

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz, and Marek Strączkowski

clamp study at the end of the program. Measurement of insulin sensitivity Insulin sensitivity was measured with the 2 h hyperinsulinemic-euglycemic clamp ( 27 , 28 ). On the morning of the study, two venous catheters were inserted into

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A placebo-controlled randomized study with testosterone in Klinefelter syndrome: beneficial effects on body composition

Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian A Groth, Kurt Kristensen, Anne Grethe Jurik, Niels H Birkebæk, and Claus H Gravholt

) subjects were admitted to the clinical research unit and confined to bed. Hyperinsulinemic euglycemic clamp At 08:00 h ( t  = −180 min) a catheter was placed into an antecubital vein for infusion of saline to maintain catheter patency. Another

Open access

Accelerated metabolic susceptibility to type 2 diabetes in older women with a history of gestational diabetes

Alice S Ryan, John C McLenithan, and Gretchen M Zietowski

low-density-lipoprotein cholesterol (LDL-C) was calculated by the Friedewald equation (18) . Hyperinsulinemic–euglycemic clamps Peripheral tissue sensitivity to exogenous insulin was measured using a 3 h hyperinsulinemic–euglycemic clamp technique

Open access

Serum and adipose tissue chemerin is differentially related to insulin sensitivity

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Magdalena Stefanowicz, Natalia Matulewicz, Irina Kowalska, and Marek Strączkowski

sensitivity measurement with the 2-h hyperinsulinemic-euglycemic clamp and SAT biopsy were performed as described previously ( 22 ). Insulin sensitivity (M value) was calculated per fat-free mass (ffm). Biochemical measurements Plasma glucose, serum

Open access

The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes

Julia Otten, Andreas Stomby, Maria Waling, Elin Chorell, Mats Ryberg, Michael Svensson, Jens Juul Holst, and Tommy Olsson

or a Paleolithic diet combined with supervised exercise. At baseline and after 12 weeks of intervention, patients were examined with a solid mixed meal test, hyperinsulinemic-euglycemic clamping, and liver magnetic resonance spectroscopy. This paper

Open access

Association of metabolic syndrome components with circulating levels of cytokine clusters in young women

Xingrong Tan, Wenjing Hu, Shan Yang, Han Dai, Shangcheng Xu, Gangyi Yang, Ling Li, Shiguo Tang, and Yi Wang

impact of high insulin levels on circulating ZAG, irisin, and betatrophin concentrations by the euglycemic–hyperinsulinemic clamp (EHC). We also compared the characteristics of each MetS component in the study population. Materials and methods