hyperinsulinemic–euglycemic clamp (plasma glucose clamped at 5.0 mmol/l, insulin 0.6 mU/kg per min, Actrapid, Novo Nordisk, Copenhagen, Denmark) was performed from t =120 to t =300 min. The period from t =0 to t =120 min is referred to as the basal period and
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Esben Thyssen Vestergaard, Morten B Krag, Morten M Poulsen, Steen B Pedersen, Niels Moller, Jens Otto Lunde Jorgensen, and Niels Jessen
C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby, and M D Robertson
period, participants completed a 7-day food and drink diary and a 7-day bowel habit and symptom diary. Participants attended for three study visits at the end of each intervention: i) a two-step euglycemic–hyperinsulinemic clamp combined with an infusion
Sandra Pereira, Jessy Moore, Jia-Xu Li, Wen Qin Yu, Husam Ghanim, Filip Vlavcheski, Yemisi Deborah Joseph, Paresh Dandona, Allen Volchuk, Carolyn L Cummins, Evangelia Tsiani, and Adria Giacca
infusion study and an infusion study followed by a hyperinsulinemic-euglycemic clamp. An overnight fast was started on the second experiment day for both types of studies. In the basal infusion study, the treatment was infused for 48 h and this was followed
Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller, and Henning Grønbæk
followed by a two-hour hyperinsulinemic euglycemic clamp period. Ethics The Danish Ethical Committee approved the study (1-10-71-410-12) and registered at clinicaltrials.gov (Nbib1705782). Both written and oral consents were obtained before
Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian A Groth, Kurt Kristensen, Anne Grethe Jurik, Niels H Birkebæk, and Claus H Gravholt
) subjects were admitted to the clinical research unit and confined to bed. Hyperinsulinemic euglycemic clamp At 08:00 h ( t = −180 min) a catheter was placed into an antecubital vein for infusion of saline to maintain catheter patency. Another
Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz, and Marek Strączkowski
clamp study at the end of the program. Measurement of insulin sensitivity Insulin sensitivity was measured with the 2 h hyperinsulinemic-euglycemic clamp ( 27 , 28 ). On the morning of the study, two venous catheters were inserted into
Alice S Ryan, John C McLenithan, and Gretchen M Zietowski
low-density-lipoprotein cholesterol (LDL-C) was calculated by the Friedewald equation (18) . Hyperinsulinemic–euglycemic clamps Peripheral tissue sensitivity to exogenous insulin was measured using a 3 h hyperinsulinemic–euglycemic clamp technique
Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Magdalena Stefanowicz, Natalia Matulewicz, Irina Kowalska, and Marek Strączkowski
sensitivity measurement with the 2-h hyperinsulinemic-euglycemic clamp and SAT biopsy were performed as described previously ( 22 ). Insulin sensitivity (M value) was calculated per fat-free mass (ffm). Biochemical measurements Plasma glucose, serum
Julia Otten, Andreas Stomby, Maria Waling, Elin Chorell, Mats Ryberg, Michael Svensson, Jens Juul Holst, and Tommy Olsson
or a Paleolithic diet combined with supervised exercise. At baseline and after 12 weeks of intervention, patients were examined with a solid mixed meal test, hyperinsulinemic-euglycemic clamping, and liver magnetic resonance spectroscopy. This paper
Xingrong Tan, Wenjing Hu, Shan Yang, Han Dai, Shangcheng Xu, Gangyi Yang, Ling Li, Shiguo Tang, and Yi Wang
impact of high insulin levels on circulating ZAG, irisin, and betatrophin concentrations by the euglycemic–hyperinsulinemic clamp (EHC). We also compared the characteristics of each MetS component in the study population. Materials and methods