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Marra Jai Aghajani
Marra Jai Aghajani
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Tao Yang
Tao Yang
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Ulf Schmitz
Ulf Schmitz
Computational BioMedicine Laboratory Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Gene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Faculty of Medicine & Health, The University of Sydney, Camperdown, New South Wales, Australia
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Gene & Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia
Faculty of Medicine & Health, The University of Sydney, Camperdown, New South Wales, Australia
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Alexander James
Alexander James
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
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Charles Eugenio McCafferty
Charles Eugenio McCafferty
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Paul de Souza
Paul de Souza
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
School of Medicine, University of Wollongong, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
School of Medicine, University of Wollongong, New South Wales, Australia
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Navin Niles
Navin Niles
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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Tara L Roberts
Tara L Roberts
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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responses in selected patients across multiple cancer types, including thyroid cancer ( 13 , 14 ). However, optimal biomarkers predictive of patient response are currently lacking ( 15 ). Epithelial-to-mesenchymal transition (EMT) is a biological process
Shikai Gui
Shikai Gui
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Wanli Yu
Wanli Yu
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Jiabao Xie
Jiabao Xie
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Lunshan Peng
Lunshan Peng
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Yuanyuan Xiong
Yuanyuan Xiong
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
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Zhen Song
Zhen Song
Nanchang University, Nanchang, Jiangxi Province, China
Department of Urology, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Department of Urology, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Haitao Luo
Haitao Luo
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Juexian Xiao
Juexian Xiao
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Shengtao Yuan
Shengtao Yuan
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu Province, China
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Zujue Cheng
Zujue Cheng
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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found that SLC7A11 functions as an invasive biomarker and was highly expressed in invasive PitNETs. In addition, knockdown of SLC7A11 inhibited epithelial–mesenchymal transition (EMT) through the PI3K/AKT signaling pathway. Materials and methods
Weiwei Liang
Weiwei Liang
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Yilin Zhang
Yilin Zhang
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
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Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
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Yan Guo
Yan Guo
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Pengyuan Zhang
Pengyuan Zhang
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Jiewen Jin
Jiewen Jin
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Hongyu Guan
Hongyu Guan
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Yanbing Li
Yanbing Li
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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.05. Knockdown of FLNA suppresses epithelial–mesenchymal transition in PTC cells To identify the potential mechanisms of FLNA regulatory effects on PTC cell migration and invasion, we conducted GSEA to analyze the enriched signaling pathways in FLNA high and
Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Celine Corbisier de Meaultsart
Celine Corbisier de Meaultsart
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
Oregon Health and Science University, Portland, Oregon, USA
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Jim Scurry
Jim Scurry
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Nicole M Verrills
Nicole M Verrills
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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when the oxygen and pH levels of the tumour tissue become direct drivers of gene expression. Interestingly, TGFB1, which is essential for epithelial-to-mesenchymal transition of metastatic cells ( 20 ) and is regulated by the RAS, was strongly
Zuyao Chen
Zuyao Chen
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Xiaolin Zhong
Xiaolin Zhong
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Weiqiang Tang
Weiqiang Tang
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Min Xia
Min Xia
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Chang Liu
Chang Liu
Department of Endocrinology and Metabolism, The First People's Hospital of Chenzhou, Chenzhou, China
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Yinping Guo
Yinping Guo
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Yan Yi
Yan Yi
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Qingshan Jiang
Qingshan Jiang
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Xuyu Zu
Xuyu Zu
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Jing Zhong
Jing Zhong
The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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-related deaths because of its high capacity for invasion and metastasis ( 5 ). Thus, it remains vital to search for a potential strategy to inhibit the invasion and migration of PTC and ATC. Epithelial-to-mesenchymal transition (EMT) is an important biological
Weiwei Liang
Weiwei Liang
W Liang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Junxin Chen
Junxin Chen
J Chen, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guang Zhou, China
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Hai Li
Hai Li
H Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Pengyuan Zhang
Pengyuan Zhang
P Zhang, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Hongyu Guan
Hongyu Guan
H Guan, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Yanbing Li
Yanbing Li
Y Li, Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guanzhou, China
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Background: Collagen type VIII α 1 chain (COL8A1), a collagen type VIII protein, has been suggested to exert various functions in progression of multiple cancers. However, the effect of COL8A1 in papillary thyroid cancer (PTC) has not been elucidated.
Methods: The Cancer Genome Atlas (TCGA) databases were applied to investigate the COL8A1 expression and its clinical significance in PTC. The COL8A1 expression level was further validated using Gene Expression Omnibus (GEO) data and clinical paired PTC tissues. Additionally, Kaplan-Meier curve was used to analyze the prognosis. The cell migrative and invasive abilities were evaluated by wound healing assay and Transwell assay. CCK8 assays were used to evaluate proliferation of PTC cells. Western blotting was conducted to explore the potential mechanisms involved in the pro-tumor role of COL8A1. The correlation between immune cell infiltration and COL8A1 was analyzed using Tumor Immune Estimation Resource (TIMER) database and the single-sample GSEA (ssGSEA) method.
Results: We found that COL8A1 was upregulated in PTC (P<0.05). High COL8A1 expression level was significantly associated with advanced T stage (P<0.01), N stage (P<0.001) and poor prognosis (P=0.0142) in PTC. Furthermore, cell migration and invasion were significantly reduced following COL8A1 knockdown (P<0.001). Mechanistic studies demonstrated that the epithelial-to-mesenchymal transition (EMT) related proteins (FN1, MMP9, MMP7, ZEB2 and Twist1) and phosphorylation of AKT and ERK were obviously down-regulated after COL8A1 knockdown (P<0.01). Moreover, COL8A1 expression was correlated with immune cell infiltration.
Conclusion: Our study demonstrates that COL8A1 may function as an oncogene and a potential prognostic biomarker for PTC patients.
María J Gómora
María J Gómora
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Flavia Morales-Vásquez
Flavia Morales-Vásquez
Departamento de Oncología Médica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Enrique Pedernera
Enrique Pedernera
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Delia Perez-Montiel
Delia Perez-Montiel
Departamento de Patología, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Horacio López-Basave
Horacio López-Basave
Departamento de Cirugía Oncológica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Antonio R Villa
Antonio R Villa
División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Azucena Hernández-Martínez
Azucena Hernández-Martínez
Hospital Militar de Especialidades de la Mujer y Neonatología, Secretaría de la Defensa Nacional, CdMx, Mexico
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Esteban Mena
Esteban Mena
Unidad de Apoyo Académico, Secretaría General, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Carmen Mendez
Carmen Mendez
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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that can increase the incidence as well as tumor aggressiveness ( 8 , 9 , 10 ). Sexual steroid hormones acting through their receptors regulate signaling pathways related to cell proliferation, epithelial–mesenchymal transition, apoptosis, cell
Enrique Pedernera
Enrique Pedernera
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Flavia Morales-Vásquez
Flavia Morales-Vásquez
Instituto Nacional de Cancerología, Ciudad de México, México
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María J Gómora
María J Gómora
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Miguel A Almaraz
Miguel A Almaraz
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Esteban Mena
Esteban Mena
Universidad Nacional Autónoma de México, Facultad de Medicina, Secretaría General, Ciudad de México, México
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Delia Pérez-Montiel
Delia Pérez-Montiel
Instituto Nacional de Cancerología, Ciudad de México, México
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Elizabeth Rendon
Elizabeth Rendon
Hospital Militar de Especialidades de la Mujer y Neonatología. Ciudad de México, México
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Horacio López-Basave
Horacio López-Basave
Instituto Nacional de Cancerología, Ciudad de México, México
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Juan Maldonado-Cubas
Juan Maldonado-Cubas
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Carmen Méndez
Carmen Méndez
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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consider the expression of ERβ in tumor cells, as its presence has been proposed as tumor suppressor by reducing cell cycle-related proteins and inhibiting epithelial-to-mesenchymal transition in ovarian cancer cell lines ( 37 , 38 ). Interestingly, the
Juan Carlos Juárez-Cruz
Juan Carlos Juárez-Cruz
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Miriam Daniela Zuñiga-Eulogio
Miriam Daniela Zuñiga-Eulogio
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Monserrat Olea-Flores
Monserrat Olea-Flores
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Eduardo Castañeda-Saucedo
Eduardo Castañeda-Saucedo
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Miguel Ángel Mendoza-Catalán
Miguel Ángel Mendoza-Catalán
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Carlos Ortuño-Pineda
Carlos Ortuño-Pineda
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Ma Elena Moreno-Godínez
Ma Elena Moreno-Godínez
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Sócrates Villegas-Comonfort
Sócrates Villegas-Comonfort
Instituto de Fisiología Celular, Universidad Nacional Autónoma de Mexico, Mexico City, México
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Teresita Padilla-Benavides
Teresita Padilla-Benavides
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Napoleón Navarro-Tito
Napoleón Navarro-Tito
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Somanath PR . Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis . Life Sciences 2016 52 – 61 . ( https://doi.org/10.1016/j.lfs.2016.05.036 )
Xianghe Chen
Xianghe Chen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xinyu Zeng
Xinyu Zeng
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiao Qiu
Xiao Qiu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Chi Liu
Chi Liu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Pengcheng Lu
Pengcheng Lu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Ziming Shen
Ziming Shen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiangxiang Zhou
Xiangxiang Zhou
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Kang Yang
Kang Yang
Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
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interstitial fibrosis in T2DM, and then improve the pathological structure of renal tissue and renal function, which was related to the upregulation of the TGF-β1/p38 mitogen-activated protein kinase (p38 MAPK) pathway and epithelial–mesenchymal transition and
