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Ningning Gong Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China

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Cuixia Gao Department of Ultrasonic Diagnosis, Gansu Provincial Hospital, Lanzhou, China

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Xuedi Chen Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Yu Wang Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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subjects ( 22 ). We speculated that these differences may be associated with TSH levels. Our present study aimed to explore changes of endothelial function in rats with sHT exhibiting different levels of TSH. The relationship between APN, chemerin and TNF

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0007
Volume/Issue:
Volume 7: Issue 2
Open access
Ningning Gong Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China

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Cuixia Gao Department of Ultrasonic Diagnosis, Gansu Provincial Hospital, Lanzhou, China

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Xuedi Chen Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Yu Wang Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Article Type:
Correction
DOI:
https://doi.org/10.1530/EC-18-0007e
Volume/Issue:
Volume 7: Issue 4
Open access
Aasem Saif Internal Medicine Department, Cairo University, Cairo, Egypt

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Shrook Mousa Internal Medicine Department, Cairo University, Cairo, Egypt

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Maha Assem Internal Medicine Department, Cairo University, Cairo, Egypt

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Nashwa Tharwat National Nutrition Institute, Cairo, Egypt

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Alaa Abdelhamid Internal Medicine Department, Cairo University, Cairo, Egypt
Vascular Laboratory, Cairo University, Cairo, Egypt

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same skilled sonographer. Endothelial function has been assessed by measuring the percent of change in blood flow following heat-mediated vasodilation using laser Doppler flowmetry (Pen Flux System 5000, Perimed AB) in patients and controls. Skin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0194
Volume/Issue:
Volume 7: Issue 10
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Daisuke Watanabe Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Satoshi Morimoto Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Noriko Morishima Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Atsuhiro Ichihara Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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major factor in the development of atherosclerosis ( 5 ). Measurement of flow-mediated vasodilation (FMD) of the brachial artery has been widely used to assess the endothelial function in humans as a reflection of endothelial nitric oxide (NO

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0057
Volume/Issue:
Volume 10: Issue 6
Open access
Zeeshan Javed Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan

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Maria Papageorgiou Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Leigh A Madden School of Life Sciences, University of Hull, Hull, UK

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Alan S Rigby Hull York Medical School, University of Hull, Hull, UK

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Eric S Kilpatrick Department of Pathology, Sidra Medical and Research Center, Doha, Qatar

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Stephen L Atkin Royal College of Surgeons in Ireland, Al Sayh, Bahrain

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Thozhukat Sathyapalan Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

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developing subclinical atherosclerosis even at a young age ( 3 , 4 ). Endothelial dysfunction is an early indicator of the atherosclerotic process, and several studies have demonstrated abnormal endothelial function assessed by flow-mediated dilation and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0173
Volume/Issue:
Volume 9: Issue 6
Open access
Kazunori Morohoshi Department of Life Sciences, Laboratory of Functional Anatomy, Faculty of Agriculture, Meiji University, Kawasaki, Japan

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Ryo Mochinaga Department of Life Sciences, Laboratory of Functional Anatomy, Faculty of Agriculture, Meiji University, Kawasaki, Japan

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Tsukasa Watanabe Department of Life Sciences, Laboratory of Functional Anatomy, Faculty of Agriculture, Meiji University, Kawasaki, Japan

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Ryojun Nakajima Department of Life Sciences, Laboratory of Functional Anatomy, Faculty of Agriculture, Meiji University, Kawasaki, Japan

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Toshio Harigaya Department of Life Sciences, Laboratory of Functional Anatomy, Faculty of Agriculture, Meiji University, Kawasaki, Japan

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properties ( 4 ). Vasoinhibins (Vi) are generated by proteolytic cleavage within the long-loop structure connecting the third helix and the fourth helix of PRL ( 5 ). Vi can act on endothelial cells to induce apoptosis and inhibit proliferation and migration

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0116
Volume/Issue:
Volume 7: Issue 5
Open access
T L C Wolters Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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C D C C van der Heijden Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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N van Leeuwen Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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B T P Hijmans-Kersten Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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M G Netea Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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J W A Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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D H J Thijssen Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK

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A R M M Hermus Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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N P Riksen Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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R T Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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, reflecting an impairment of arterial vasoprotective functioning ( 46 , 47 ). Endothelial dysfunction is considered the earliest stage of atherosclerotic disease ( 48 ), and has been reported to be present in acromegaly patients ( 3 , 6 , 33 ). Findings

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0430
Volume/Issue:
Volume 8: Issue 12
Open access
Madalena von Hafe Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

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João Sergio Neves Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal

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Catarina Vale Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

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Marta Borges-Canha Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal

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Adelino Leite-Moreira Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

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subclinical) exhibit impaired endothelial function that improves with TH replacement therapy ( 61 , 63 ). In the Rotterdam Study mentioned above, patients with SCH had higher prevalence of aortic calcification and myocardial infarction, especially those who

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0096
Volume/Issue:
Volume 8: Issue 5
Open access
Ann-Cathrin Koschker Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany

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Bodo Warrings Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany

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Caroline Morbach Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Florian Seyfried Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany

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Nicole Rickert Department of Radiology, University Hospital, University of Würzburg, Würzburg, Germany

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Pius Jung Division of Pneumology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Andreas Geier Division of Hepatology, Department of Internal Medicine II, University Hospital, University of Würzburg, Würzburg, Germany

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Ulrich Dischinger Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Maike Krauthausen Department of General Practice, University Hospital, University of Würzburg, Würzburg, Germany

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Martin J Herrmann Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany

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Christine Stier Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany

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Stefan Frantz Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Uwe Malzahn Center for Clinical Trials, University Hospital, University of Würzburg, Würzburg, Germany

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Stefan Störk Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Martin Fassnacht Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany

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the WAS Study Group
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the WAS Study Group

, endothelial function, gut microbiota, peripheral immune cells, markers of carbohydrate metabolism, adipokines, natriuretic peptides, and other hormones, as well as vitamin D metabolism. Key primary and secondary efficacy measures are described in more detail

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-21-0338
Volume/Issue:
Volume 11: Issue 2
Open access
Sahar Hossam El Hini Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt

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Yehia Zakaria Mahmoud Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt

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Ahmed Abdelfadel Saedii Department of Clinical Pathology, Faculty of Medicine, Minia University, Minia, Egypt

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Sayed Shehata Mahmoud Department of Cardiology, Faculty of Medicine, Minia University, Minia, Egypt

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Mohamed Ahmed Amin Department of Radiology, Faculty of Medicine, Minia University, Minia, Egypt

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Shereen Riad Mahmoud Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt

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Ragaa Abdelshaheed Matta Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt

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and morphological parameters of endothelial function of the peripheral muscular and central elastic arteries as assessed via flow-mediated dilation% (FMD%) of the brachial artery, carotid intima-media thickness (CIMT), and aortic stiffness index (ASI

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0398
Volume/Issue:
Volume 10: Issue 12
Open access