Qing Zhou
Qing Zhou
Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China
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Li Yong Zhang
Li Yong Zhang
Department of Thyroid Surgery, Minimal Invasive Center, Fujian Medical University Union Hospital, Fuzhou, China
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Mei Feng Dai
Mei Feng Dai
Department of Clinical Lab, Fujian Maternity and Child Health Hospital, Fuzhou, China
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Zhen Li
Zhen Li
Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China
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Chao Chun Zou
Chao Chun Zou
Department of Endocrinology, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Hui Liu
Hui Liu
Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China
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adipocytes has not been elucidated. The endoplasmic reticulum (ER) is the main organelle responsible for the synthesis, processing, and secretion of proteins, as well as the metabolism of lipids and glucose. Extensive studies have shown that ER stress is
Bo Zhu
Bo Zhu
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Yumei Chen
Yumei Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Fang Xu
Fang Xu
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xiaolu Shen
Xiaolu Shen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xuanyu Chen
Xuanyu Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Jieqiang Lv
Jieqiang Lv
Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Songying Zhang
Songying Zhang
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
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etiology of PCOS is complex and unclear, recent studies reveal that androgens excess and endoplasmic reticulum (ER) stress play important roles in the progression and pathogenesis of PCOS ( 7 , 8 , 9 ). Clinical studies showed that hyperandrogenism is
Sandra Pereira
Sandra Pereira
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Jessy Moore
Jessy Moore
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Jia-Xu Li
Jia-Xu Li
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Wen Qin Yu
Wen Qin Yu
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Husam Ghanim
Husam Ghanim
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Filip Vlavcheski
Filip Vlavcheski
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Yemisi Deborah Joseph
Yemisi Deborah Joseph
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Paresh Dandona
Paresh Dandona
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Allen Volchuk
Allen Volchuk
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Carolyn L Cummins
Carolyn L Cummins
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Evangelia Tsiani
Evangelia Tsiani
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Adria Giacca
Adria Giacca
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Introduction Obesity is characterized by elevated circulating free fatty acids (FFAs) that cause insulin resistance in the liver and periphery ( 1 , 2 ). FFAs induce endoplasmic reticulum (ER) stress, which occurs when misfolded or unfolded
Selina Mäkinen
Selina Mäkinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Yen H Nguyen
Yen H Nguyen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Paulina Skrobuk
Paulina Skrobuk
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Heikki A Koistinen
Heikki A Koistinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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283 11107 – 11116 . ( doi:10.1074/jbc.M708700200 ) 12 Peng G Li L Liu Y Pu J Zhang S Yu J Zhao J Liu P. Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and
Wenrui Wang
Wenrui Wang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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Chuan Zhang
Chuan Zhang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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metabolic, oxidative, and endoplasmic reticulum stresses; and on epigenetic changes due to chronic stress. We also review current antidiabetic strategies and potential future research directions that may identify a time window for alleviating the β
Xiuhua Liao
Xiuhua Liao
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China
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Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China
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Suqin Zhu
Suqin Zhu
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
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Shumin Qiu
Shumin Qiu
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
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Hua Cao
Hua Cao
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
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Wenwen Jiang
Wenwen Jiang
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
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Huiling Xu
Huiling Xu
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
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Yan Sun
Yan Sun
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
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Beihong Zheng
Beihong Zheng
Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China
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Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China
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A Xu Z Tanaka T Sakaguchi N Kunitomi C Azhary JMK Takahashi N Urata Y , et al. Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome . Frontiers in Endocrinology 2023 14 1124405 . ( https
Xuhua Mao
Xuhua Mao
Department of Clinical Laboratory, Yixing People’s Hospital, Yixing, Wuxi, Jiangsu, China
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Hucheng Chen
Hucheng Chen
Department of Nuclear Medicine, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China
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Junmin Tang
Junmin Tang
Department of Clinical Laboratory, Yixing People’s Hospital, Yixing, Wuxi, Jiangsu, China
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Liangliang Wang
Liangliang Wang
Department of Neurology, Yixing People’s Hospital Affiliated to Jiangsu University, Yixing, Wuxi, Jiangsu, China
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Tingting Shu
Tingting Shu
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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). Indeed, stimulation with high glucose leads to increased self-oxidation, generating large amounts of reactive oxygen species (ROS), which inevitably induces endoplasmic reticulum (ER) stress and inhibits insulin synthesis ( 23 ). However, the ER stress
Tsung-Hui Wu
Tsung-Hui Wu
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Guan-Yu Su
Guan-Yu Su
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Tsung-Yun Liu
Tsung-Yun Liu
Institute of Food Safety and Health Risk Assessment, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
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Hsiang-Tsui Wang
Hsiang-Tsui Wang
Institute of Food Safety and Health Risk Assessment, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, Taiwan
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Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, Taiwan
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Chii-Min Hwu
Chii-Min Hwu
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Faculty of Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan
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Faculty of Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan
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effects through various mechanisms, including DNA and protein adduction, disruption of mitochondria and endoplasmic reticulum, cell membrane damage, oxidative stress, and inflammation and immune dysfunction ( 8 ). Due to an abundance of polyunsaturated
Eric Seidel
Eric Seidel
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
Berlin Institute of Health (BIH), Berlin, Germany
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
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Berlin Institute of Health (BIH), Berlin, Germany
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
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Gudrun Walenda
Gudrun Walenda
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
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Clemens Messerschmidt
Clemens Messerschmidt
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
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Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
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Benedikt Obermayer
Benedikt Obermayer
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
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Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
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Mirko Peitzsch
Mirko Peitzsch
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
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Paal Wallace
Paal Wallace
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
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Rohini Bahethi
Rohini Bahethi
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
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Taekyeong Yoo
Taekyeong Yoo
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
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Murim Choi
Murim Choi
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
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Petra Schrade
Petra Schrade
Charité – Universitaetsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Vegetative Anatomie, Berlin, Germany
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Sebastian Bachmann
Sebastian Bachmann
Charité – Universitaetsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Vegetative Anatomie, Berlin, Germany
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Gerhard Liebisch
Gerhard Liebisch
Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany
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Graeme Eisenhofer
Graeme Eisenhofer
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
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Dieter Beule
Dieter Beule
Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
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Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
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Ute I Scholl
Ute I Scholl
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
Berlin Institute of Health (BIH), Berlin, Germany
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
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Berlin Institute of Health (BIH), Berlin, Germany
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany
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previous study ( 13 ), downregulation of SREBF1 , encoding sterol regulatory binding transcription factor 1, was demonstrated. Also, expression of genes involved in endoplasmic reticulum stress response was significantly altered, including upregulation of
Tingting Shu
Tingting Shu
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Zhigang Lv
Zhigang Lv
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Yuchun Xie
Yuchun Xie
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Junming Tang
Junming Tang
Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China
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Xuhua Mao
Xuhua Mao
Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China
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), ( 19 ) which influences the energy supply required for insulin secretion ( 20 ). Moreover, mitochondrial function becomes impaired, which induces endoplasmic reticulum stress response (ER stress), leading to β-cell apoptosis ( 21 , 22 ). In the
