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Renea A Taylor, Jennifer Lo, Natasha Ascui and Matthew J Watt

daily physical activity, age and an individual's metabolic and endocrine profile. The assessment of such phenotypic traits will be important in providing insights into the causal role of obesity-related metabolic abnormalities on prostate cancer

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Wafaa M Rashed, Anas Saad, Muneer Al-Husseini, Ahmed Mahmoud Galal, Assem Mohamed Ismael, Ahmed M Al-Tayep, Ayman El Shafie, Mahmoud Ahmed Ali and Ahmad Samir Alfaar

Introduction The adrenal gland malignancies are extremely sporadic and heterogeneous. It represents 3.6% of endocrine glands cancers ( 1 ). Adrenal malignancies can be either primary adrenal tumors or secondary metastases, with metastases

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J Brossaud, V Pallet and J-B Corcuff

GA. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer . Endocrine-Related Cancer 2006 13 797 – 826 . ( doi:10.1677/erc.1.01143 ) 10.1677/erc.1.01143 16954431 45 Grunwald F Pakos E Bender H Menzel

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C E Higham, A Olsson-Brown, P Carroll, T Cooksley, J Larkin, P Lorigan, D Morganstein, P J Trainer and the Society for Endocrinology Clinical Committee

Medicine 2015 373 23 – 34 . ( ) 10.1056/NEJMoa1504030 7 Torino F Baranbei A Paragliola R Marchetti P Salvatori R Corsello SM . Endocrine side effects of anti-cancer drugs: mAbs and pituitary

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Anita Hokken-Koelega, Aart-Jan van der Lely, Berthold Hauffa, Gabriele Häusler, Gudmundur Johannsson, Mohamad Maghnie, Jesús Argente, Jean DeSchepper, Helena Gleeson, John W Gregory, Charlotte Höybye, Fahrettin Keleştimur, Anton Luger, Hermann L Müller, Sebastian Neggers, Vera Popovic-Brkic, Eleonora Porcu, Lars Sävendahl, Stephen Shalet, Bessie Spiliotis and Maithé Tauber

QoL, and a low activity level. The third and last scientific session of the meeting focused on patients with endocrine sequelae as a result of craniopharyngiomas or cancer therapy administered during childhood. Dr Hermann Müller opened the session

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Ruth Therese Casey, Deborah Saunders, Benjamin George Challis, Deborah Pitfield, Heok Cheow, Ashley Shaw and Helen Lisa Simpson

Burgess JR Valk GD & International Breast Cancer in MEN1 Study Group. Breast-cancer predisposition in multiple endocrine neoplasia type 1 . New England Journal of Medicine 2014 371 583 – 584 . ( doi:10.1056/NEJMc1406028 )

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Luminita Nicoleta Cima, Anca Colita and Simona Fica

in patients with different types of cancer ( 23 , 24 ). Still, the possible utility of this technique of preserving normal ovarian function and fertility in HSCT recipients has not yet been established ( 25 ). Methods This is a literature

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Irasema Mendieta, Rosa Elvira Nuñez-Anita, Gilberto Pérez-Sánchez, Lenin Pavón, Alfredo Rodríguez-Cruz, Guadalupe García-Alcocer and Laura Cristina Berumen

.2016.152 38 Yuan TC Veeramani S Lin MF . Neuroendocrine-like prostate cancer cells: neuroendocrine transdifferentiation of prostate adenocarcinoma cells . Endocrine-Related Cancer 2007 14 531 – 547 . (

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Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

. ( doi:10.3275/8332 ). 11 Smith VE Franklyn JA McCabe CJ . Pituitary tumor-transforming gene and its binding factor in endocrine cancer . Expert Reviews in Molecular Medicine 2010 12 e38 . ( doi:10.1017/S1462399410001699 ). 12 Löfgren SE

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Rocío del Carmen Bravo-Miana, Ana Belén Della Vedova, Ana Lucía De Paul, María Mónica Remedi, María Laura Guantay, Mónica Beatriz Gilardoni, Claudia Gabriela Pellizas and Ana Carolina Donadio

Tumor-stroma crosstalk leads to a tumor-promoting microenvironment. In this milieu, extracellular vesicles (EVs) are protagonists in cell-cell communication. Despite thyroid cancer being the most common endocrine malignancy, the contribution of the tumor microenvironment to thyroid cancer progression is still largely underexplored. We focused on the role of thyroid tumor cell-fibroblast interaction and EVs as mediators of tumor-stroma interplay, in the promotion of thyroid tumor aggressiveness. Thyroid tumor (TPC-1, 8505c) or non-tumor thyroid cells (NThyOri) were co-cultured with human fibroblasts (Fb). Thyroid cell migration was investigated by the wound-healing assay and actin-network staining. Cell-CD147 expression was characterized by flow cytometry. EVs, obtained by ultracentrifugation of conditioned media (CMs), were characterized by transmission electron-microscopy and CD81 and CD147 expression. Metalloproteinases (MMPs) were evaluated by zymography in CMs. A migratory phenotype was triggered in thyroid tumor cells treated with CMs from Fb or from Fb-thyroid tumor cell co-cultures. Fb-thyroid cell co-cultures induced the secretion of proMMP9 and proMMP2, and led to a significant MMP2 activation in CMs. Fb, thyroid cells and Fb-thyroid cell co-cultures released EVs, and remarkably, EVs released by Fb-thyroid tumor cell co-cultures induced the secretion of proMMP2 and the expression of MMP2 from normal Fb. A significant CD147 expression was demonstrated in Fb-thyroid tumor cell derived EVs. These findings reveal the role of Fb and thyroid tumor cell-Fb interaction in the promotion of a microenvironment suitable for thyroid tumor progression. Moreover, they highlight for the first time the role of thyroid tumor cell-Fb interaction in the production of specialized EVs.