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The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Zeeshan Javed, Maria Papageorgiou, Leigh A Madden, Alan S Rigby, Eric S Kilpatrick, Stephen L Atkin, and Thozhukat Sathyapalan

treatment with exenatide resulted in reductions in serum ICAM-1, p-selectin and e-selectin, although no pronounced changes were seen in endothelial function ( 25 ). Empagliflozin is a sodium-glucose cotransporter 2 (SGLT-2) inhibitor used in the treatment

Open access

Effects of SGLT2 inhibition on lipid transport in adipose tissue in type 2 diabetes

Katrine M Lauritsen, Jens Hohwü Voigt, Steen Bønløkke Pedersen, Troels K Hansen, Niels Møller, Niels Jessen, Lars C Gormsen, and Esben Søndergaard

(diabetes duration > 1 year; HbA1c 6.5–9.0% (48–75 mmol/mol) treated with metformin were randomized to empagliflozin 25 mg and placebo once-daily in a randomized, double-blinded, placebo-controlled crossover design. Patients were recruited through

Open access

Improvement of skeletal muscle insulin sensitivity by 1 week of SGLT2 inhibitor use

Yuka Goto, Yoshie Otsuka, Kenji Ashida, Ayako Nagayama, Nao Hasuzawa, Shimpei Iwata, Kento Hara, Munehisa Tsuruta, Nobuhiko Wada, Seiichi Motomura, Yuji Tajiri, and Masatoshi Nomura

). Experimental protocol Empagliflozin, an SGLT2 inhibitor, was orally administered at a dose of 10 mg/day for 1 week. Metabolic and anthropometric data were collected before and 1 week after the initiation of empagliflozin. Metabolic parameters included plasma

Open access

SGLT2 inhibitors for patients with type 2 diabetes and CKD: a narrative review

Merlin C Thomas, Brendon L Neuen, Stephen M Twigg, Mark E Cooper, and Sunil V Badve

sotagliflozin, while kidney function declined in the placebo group (sotagliflozin 0.09 mL/min/1.73 m 2 /year vs placebo −1.31 mL/min/1.73 m 2 /year) ( 14 ). Finally, the EMPA-KIDNEY trial ( 12 ) assessed the effect of empagliflozin compared with placebo in

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Chronic kidney disease in patients with diabetes mellitus

Espen Nordheim and Trond Geir Jenssen

reduced hyperfiltration and improved proteinuria, might also have a role. Promising results were found with the SGLT2-inhibitors early in the cardiovascular safety studies, for example, with empagliflozin (EMPA-REG), canagliflozin (CANVAS) and

Open access

The changing landscape of automated insulin delivery in the management of type 1 diabetes

Rama Lakshman, Charlotte Boughton, and Roman Hovorka

limited due to an increased risk of euglycaemic ketoacidosis ( 77 ). In outpatient crossover RCTs utilising the iPancreas AID system, 25 mg empagliflozin daily with HCL led to an increase in time in range compared to HCL alone ( 78 ), and 25 mg

Open access

Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties

Ann-Kristin Picke, Graeme Campbell, Nicola Napoli, Lorenz C Hofbauer, and Martina Rauner

2, the key transporter mediating glucose reabsorption by the kidney), thereby increasing urinary glucose excretion ( 164 , 165 ). The first three SGLT2 inhibitors released in the market, namely canagliflozin, empagliflozin and dapagliflozin, have

Open access

Frequency and characteristics of diabetes in lipodystrophies and insulin receptoropathies compared with type 1 and type 2: results from the multicenter DPV registry

Clemens Kamrath, Alexander Eckert, Birgit Rami-Merhar, Sebastian Kummer, Martin Wabitsch, Katharina Laubner, Florian Kopp, Silvia Müther, Steffen Mühldorfer, and Reinhard W Holl

-glucose cotransporter 2 inhibitor, empagliflozin, in a patient with Rabson-Mendenhall syndrome . Hormone Research in Paediatrics 2021 94 313 – 316 . ( ) 27 Nagashima S Wakabayashi T Saito N Takahashi M Okada K Ebihara K

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Diabetes control is associated with environmental quality in the USA

Jyotsna S Jagai, Alison K Krajewski, Kyla N Price, Danelle T Lobdell, and Robert M Sargis

D Bluhmki E Hantel S Mattheus M Devins T Johansen OE Woerle HJ et al . Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes . New England Journal of Medicine 2015 373 2117 – 2128 . (

Open access

AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients

Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ, and Albert Beckers

difficult to control (HbA1c: 9.2%) on multiple therapies (dulaglutide, metformin, empagliflozin and gliclazide); she had ongoing problems with obesity (bariatric surgery was planned) and a diagnosis of non-alcoholic steatohepatitis (NASH) was established