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M S Elston, V B Crawford, M Swarbrick, M S Dray, M Head, and J V Conaglen

tumours (NET) (8.9–14%) and phaeochromocytomas (2.5–5.6%) ( 1 , 2 , 3 ). Sources of ectopic ACTH production arising in the pelvis are rare although EAS has been described due to gonadal tumours (adenocarcinoma, androblastoma, Sertoli cell tumour

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Benedetta Zampetti, Erika Grossrubatscher, Paolo Dalino Ciaramella, Edoardo Boccardi, and Paola Loli

. ( doi:10.1016/s0140-6736(86)90113-3 ) 3 Howlett TA Drury PL Perry L Doniach I Rees LH Besser GM. Diagnosis and management of ACTH-dependent Cushing’s syndrome: comparison of the features in ectopic and pituitary ACTH production

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Kush Dev Singh Jarial, Anil Bhansali, Vivek Gupta, Paramjeet Singh, Kanchan K Mukherjee, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva, and Rama Walia

Introduction The differential diagnosis of ACTH-dependent Cushing’s syndrome (CS) as pituitary or ectopic source of ACTH production is often challenging for the physicians as none of the biochemical tests or imaging modalities have 100

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Filippo Ceccato, Diego Cecchin, Michele Gregianin, Giacomo Ricci, Cristina Campi, Filippo Crimì, Marta Bergamo, Annibale Versari, Carmelo Lacognata, Federico Rea, Mattia Barbot, and Carla Scaroni

-pituitary neoplasm (ectopic ACTH secretion, EAS) ( 1 , 2 , 3 , 4 ). Achieving the goals of CS treatment (to normalize cortisol levels, to reverse the clinical symptoms and to remove the secreting neoplasm) is a challenge, especially in EAS ( 5 , 6 ). EAS is

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Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

patients with Cushing’s disease due to excess pituitary ACTH or Cushing’s syndrome caused by ectopic ACTH production. It is important, however, to reiterate that many genes that are transcriptionally regulated by ACTH encode factors which are subject to non

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Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark, and Li F Chan

-opiomelanocortin, lipotrophins and Met-enkephalin, corticotropin-like intermediate peptide (CLIP) (reviewed in 4 , 5 ). ACTH is released into the circulation to act on peripheral sites, mainly the adrenal glands to stimulate glucocorticoid hormone production. Glucocorticoids

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Carla Scaroni, Nora M Albiger, Serena Palmieri, Davide Iacuaniello, Chiara Graziadio, Luca Damiani, Marialuisa Zilio, Antonio Stigliano, Annamaria Colao, Rosario Pivonello, and the Altogether to Beat Cushing’s Syndrome (ABC) study group

sensitivity to feedback inhibition by DST Increased 5 α-reductase type 1 activity in the liver Upregulation of cortisol output due to great expression of 11β-HSD type 1 Alcohol abuse Stimulated CRH production with increased ACTH levels

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Soraya Puglisi, Paola Perotti, Mattia Barbot, Paolo Cosio, Carla Scaroni, Antonio Stigliano, Pina Lardo, Valentina Morelli, Elisa Polledri, Iacopo Chiodini, Giuseppe Reimondo, Anna Pia, and Massimo Terzolo

Introduction Cushing’s syndrome (CS) is a condition of endogenous hypercortisolism caused by different pathological entities that is classified in two variants: (i) ACTH-dependent CS, due to a corticotroph pituitary adenoma or an ectopic tumor

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Ferdinand Roelfsema, Diana van Heemst, Ali Iranmanesh, Paul Takahashi, Rebecca Yang, and Johannes D Veldhuis

, Endocrine Societies have formulated clear guidelines. The most challenging condition is the differential diagnosis between ectopic ACTH secretion and pituitary-dependent hypercortisolemia, when imaging and pituitary blood sampling studies are equivocal

Open access

Mirjana Kocova, Vesna Janevska, and Violeta Anastasovska

adrenocorticotropic hormone (ACTH) level in the serum is high, as is frequently the case in patients with CAH, these ‘ectopic’ adrenal cells might multiply to a level of severe tumor-like hyperplasia affecting the testicular tissue and causing infertility later in