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Xiaoli Liu Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China

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Lanxiang Liu Department of Medical Imaging, The First Hospital of Qinhuangdao, Qinhuangdao, China

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Rui Wang Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China

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Xiaojiao Jia Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China

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Binbin Liu Department of Functional Examination, The First Hospital of Qinhuangdao, Qinhuangdao, China

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Ning Ma Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China

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Qiang Lu Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China

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occurred, an abnormal change in the blood glucose level may induce the occurrence of early arteriosclerosis and an increase in the blood glucose can further aggravate it. However, there have been few studies on early arteriosclerosis in populations with

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Yunting Lin Department of Surgical Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China

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Endi Song Department of Internal Medicine, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China

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Han Jin Department of Medicine, Ningbo University, Ningbo, Zhejiang, China

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Yong Jin Department of Internal Medicine, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China

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contribute to arteriosclerosis ( 10 ), with aging being the most prominent factor ( 11 ). Early detection of potential risk factors for arteriosclerosis may have clinical significance in preventing CVD and improving clinical outcomes. Arterial stiffness (AS

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Simon Chang Unit for Thrombosis Research, Institute of Regional Health Research, University of Southern Denmark and Department of Clinical Biochemistry, Hospital of South West Denmark, Esbjerg, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark

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Christian Fynbo Christiansen Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark

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Anders Bojesen Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark

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Svend Juul Department of Public Health, Aarhus University, Aarhus C, Denmark

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Anna-Marie B Münster Unit for Thrombosis Research, Institute of Regional Health Research, University of Southern Denmark and Department of Clinical Biochemistry, Hospital of South West Denmark, Esbjerg, Denmark

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Claus H Gravholt Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark

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flutter), angina pectoris, arteriosclerosis, hypertension, diabetes, and hypercholesterolemia, all co-morbidities associated with thrombosis risk ( 26 , 27 ), were also identified in The Danish National Patient Registry going back to 1977 when the

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Lukas Ochsner Ridder Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Agnethe Berglund Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

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Kirstine Stochholm Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark

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Simon Chang Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark

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Claus H Gravholt Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark

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problem in modern health care and perhaps the implementation of better screening methods, involvement of school nurses, and general information about the syndrome could lead to more KS and 47,XYY males being diagnosed earlier, increasing the likelihood of

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Nancy Martini Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral (LIOMM-UNLP-CICPBA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina

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Lucas Streckwall Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral (LIOMM-UNLP-CICPBA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina

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Antonio Desmond McCarthy Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral (LIOMM-UNLP-CICPBA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina

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density (BMD) decreases. Accumulation of arterial calcifications (ACs) in the tunica media contributes to arteriosclerosis with impaired vessel compliance and decreased distal perfusion, while in the tunica intima, ACs are associated with advanced focal

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Ningning Gong Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China

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Cuixia Gao Department of Ultrasonic Diagnosis, Gansu Provincial Hospital, Lanzhou, China

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Xuedi Chen Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Yu Wang Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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proteases. It is an indirect effect. However, research to explore the changes of adipokines in sHT and the effect of LT 4 treatment on these changes has been very limited. Endothelial dysfunction is an early step of AS ( 19 ); it is related to decreased

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Antonia Ertelt Equine Clinic, Free University of Berlin, Berlin, Germany

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Ann-Kristin Barton Equine Clinic, Free University of Berlin, Berlin, Germany

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Robert R Schmitz Equine Clinic, Free University of Berlin, Berlin, Germany

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Heidrun Gehlen Equine Clinic, Free University of Berlin, Berlin, Germany

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current knowledge, atherosclerosis does not occur in horses, but it remains to be evaluated why arteriosclerosis is not a feature of EMS. It has to be considered that there is a different amount of HDL and LDL cholesteryl esters in horses compared with

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Amar Osmancevic School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Kristin Ottarsdottir School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Margareta Hellgren School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Ulf Lindblad School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Bledar Daka School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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and were included at visit one (baseline). The focus of this cohort study was the detection of early cardiometabolic disorders, and thus the age of participants ranged between 30 and 74, with oversampling of subjects between 30 and 50 years of age

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Arpna Sharma Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Vijay Simha Baddela Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Frank Becker Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Dannenberger Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Jens Vanselow Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Meller N McNamara CA . Role of smooth muscle cells in the initiation and early progression of atherosclerosis . Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 812 – 819 . ( https://doi.org/10.1161/ATVBAHA.107.159327 ) 18276911 10

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Marcus Quinkler Endocrinology in Charlottenburg, Berlin, Germany

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Bertil Ekman Departments of Endocrinology and Medical and Health Sciences, Linköping University, Linköping, Sweden

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Claudio Marelli Shire International GmbH, Zug, Switzerland

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Sharif Uddin Shire, Lexington, Massachusetts, USA

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Pierre Zelissen Department of Internal Medicine and Endocrinology, University Medical Center Utrecht, Utrecht, the Netherlands

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Robert D Murray Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James’s University Hospital, Leeds, UK

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on behalf of the EU-AIR Investigators
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recently, a 2-year open, randomised trial found a 3.7-fold increased relative risk for cerebrovascular events in patients with early rheumatoid arthritis receiving low-dose prednisolone treatment ( 38 ). However, drawing a parallel between patients with

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