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María Dolores Rodríguez Arnao, Amparo Rodríguez Sánchez, Ignacio Díez López, Joaquín Ramírez Fernández, Jose Antonio Bermúdez de la Vega, Diego Yeste Fernández, María Chueca Guindulain, Raquel Corripio Collado, Jacobo Pérez Sánchez, Ana Fernández González, and ECOS Spain Study Collaborative Investigator Group

, to provide an e-health tool to patients ( 13 ). Despite this term has evolved in the last decade, e-health is defined by the World Health Organization (WHO) as ‘the use of information and communication technologies for health’ ( 14 ). Since easypod

Open access

Violeta Iotova, Camilla Schalin-Jäntti, Petra Bruegmann, Manuela Broesamle, Natasa Bratina, Vallo Tillmann, Olaf Hiort, and Alberto M Pereira

and an adult patient advocacy group (ePAGs) representative. The specific activities that the Network should fulfill for the initial 5 years of existence were defined ‘horizontally’ in Work Packages (WPs) – WP1: Education and Training, WP2: E-health and

Open access

Kamran Iqbal, Kate Halsby, Robert D Murray, Paul V Carroll, and Robert Petermann

once daily and more closely mimics the daytime circadian rhythm of cortisol secretion ( 6 ). The safety and efficacy of MR HC has been demonstrated in clinical trials ( 7 ). Bergthorsdottir et al . report a better health-related QoL in patients with AI

Open access

Nicolai Preisler, Pascal Laforêt, Karen Lindhardt Madsen, Edith Husu, Christoffer Rasmus Vissing, Gitte Hedermann, Henrik Galbo, Christopher Lindberg, and John Vissing

during prolonged (i.e. 1 h) moderate intensity exercise, in patients with Pompe disease. We used cycle-ergometer exercise and stable isotope methodology in combination with indirect calorimetry to determine glucose, glycerol, and fatty acid metabolism

Open access

Sarah Zaheer, Kayla Meyer, Rebecca Easly, Omar Bayomy, Janet Leung, Andrew W. Koefoed, Mahyar Heydarpour, Roy Freeman, and Gail K. Adler

Glucocorticoid use is the most common cause of secondary osteoporosis. Poor skeletal health related to glucocorticoid use is thought to involve inhibition of the Wnt/β-catenin signaling pathway, a key pathway in osteoblastogenesis. Sclerostin, a peptide produced primarily by osteocytes, is an antagonist of the Wnt/β-catenin signaling pathway, raising the possibility that sclerostin is involved in glucocorticoids’ adverse effects on bone. The aim of this study was to determine whether an acute infusion of cosyntropin (i.e., ACTH [1-24]), which increases endogenous cortisol, increases serum sclerostin levels as compared to a placebo infusion. This study was performed using blood samples obtained from a previously published, double-blind, placebo-controlled, randomized, cross-over study among healthy men and women who received infusions of placebo or cosyntropin after being supine and fasted overnight ( NCT02339506). A total of seventeen participants were analyzed. There was a strong correlation (R2 = 0.65, p < 0.0001) between the two baseline sclerostin measurements measured at the start of each visit, and men had a significantly higher average baseline sclerostin compared to women. As anticipated, cosyntropin significantly increased serum cortisol levels, whereas cortisol levels fell during placebo infusion, consistent with the diurnal variation in cortisol. There was no significant effect of cosyntropin as compared to placebo infusions on serum sclerostin over 6-24 hours (p = 0.10). In conclusion, this randomized, placebo-controlled study was unable to detect a significant effect of a cosyntropin infusion on serum sclerostin levels in healthy men and women.

Open access

Stine A Holmboe, Ravi Jasuja, Brian Lawney, Lærke Priskorn, Niels Joergensen, Allan Linneberg, Tina Kold Jensen, Niels Erik Skakkebæk, Anders Juul, and Anna-Maria Andersson

fraction of testosterone loosely bound to albumin are considered the fractions that are bioavailable for the target tissues ( 2 ). The testosterone level is affected by health status and different lifestyle factors and in general, there is agreement between

Open access

Suma Uday, Ardita Kongjonaj, Magda Aguiar, Ted Tulchinsky, and Wolfgang Högler

Global Health 2016 4 e229 – e230 . 7 Gross ML Tenenbein M Sellers EAC . Severe vitamin D deficiency in 6 Canadian First Nation formula-fed infants. International Journal of Circumpolar Health 2013 72 20244 . ( doi:10.3402/ijch.v72i0

Open access

Monika Schaffner, Ursula Rochau, Nikolai Mühlberger, Annette Conrads-Frank, Vjollca Qerimi Rushaj, Gaby Sroczynski, Eftychia Koukkou, Betina Heinsbaek Thuesen, Henry Völzke, Wilhelm Oberaigner, and Uwe Siebert

practitioner, specialist, and services and material costs reimbursable for both of them ( 30 ). The statutes of medical fees regulate the invoicing of medical services for private medical care in Germany not refundable by the statutory health insurances (e

Open access

Barbara J Boucher

vitamin D 3 or of calcitriol. Thus, vitamin D toxicity cannot be induced by sunshine in health, though hugely excessive intakes can overwhelm the regulatory system causing hypercalcaemic toxicity. Rare lymphoid disorders (e.g. sarcoidosis), with loss of

Open access

Diana-Alexandra Ertl, Andreas Gleiss, Katharina Schubert, Caroline Culen, Peer Hauck, Johannes Ott, Alois Gessl, and Gabriele Haeusler

Introduction Morbidity and mortality are generally increased in Turner syndrome (TS) ( 1 ). Therefore, extensive guidelines for the health care of young and adult patients with TS have been published ( 2 , 3 , 4 , 5 , 6 , 7 , 8 ), with a