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Małgorzata Kałużna Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Pola Kompf Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Katarzyna Wachowiak-Ochmańska Heliodor Święcicki Clinical Hospital, Poznan, Poland

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Jerzy Moczko Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland

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Aleksandra Królczyk Chair and Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Adam Janicki Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Karol Szapel Department of Physiotherapy, Poznan University of Medical Sciences, Poznan, Poland

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Marian Grzymisławski Chair and Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Katarzyna Ziemnicka Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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GI system disorder and one of the leading causes of absence from work ( 9 ). It is characterized by abdominal pain and changes in bowel habits, which allows classification of the condition into diarrhea- or constipation-predominant types, a mix of

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-21-0309
Volume/Issue:
Volume 11: Issue 4
Open access
Emmi Naskali Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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Katja Dettmer Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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Peter J Oefner Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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Pedro A B Pereira Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland

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Kai Krohn Clinical Research Institute HUCH Ltd, Biomedicum Helsinki 1, Helsinki, Finland

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Petri Auvinen Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland

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Annamari Ranki Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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Nicolas Kluger Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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questions regarding gastrointestinal function, that is, current chronic constipation or diarrhea (without any known cause) or both. The questionnaire was sent to all 37 patients. Twenty-six patients completed and returned the questionnaires (response rate

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0513
Volume/Issue:
Volume 8: Issue 1
Open access
Merete Gedde-Dahl
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Espen Thiis-Evensen
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Andreas Myklebust Tjølsen Section of Gastroenterology, University of Oslo School of Medicine, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Postboks 4953, Nydalen, 0424 Oslo, Norway

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Kjerstin Skrede Mordal
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Morten Vatn
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Deidi S Bergestuen
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with endocrine functions (1) . Small intestinal NETs often produce vasoactive substances that may result in the carcinoid syndrome, symptoms of which include flushing, diarrhea, carcinoid heart disease, and bronchospasm. The syndrome is almost

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0077
Volume/Issue:
Volume 2: Issue 1
Open access
Efstratios Kardalas Department of Endocrinology and Diabetes, Evangelismos Hospital, Athens, Greece

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Stavroula A Paschou Division of Endocrinology and Diabetes, ‘Aghia Sophia’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Panagiotis Anagnostis Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Giovanna Muscogiuri Division of Endocrinology, Department of Clinical Medicine and Surgery, ‘Federico II’ University of Naples, Naples, Italy

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Gerasimos Siasos First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Andromachi Vryonidou Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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primary hyperaldosteronism, kidney disorders and genetic syndromes affecting the renal function ( 19 ). Gastrointestinal losses of potassium usually are due to prolonged diarrhea or vomiting, chronic laxative abuse, intestinal obstruction or infections. An

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0109
Volume/Issue:
Volume 7: Issue 4
Open access
Daniel Alexander Hescheler Department of Nuclear Medicine, University Hospital Münster, Münster, Germany
European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany

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Milan Janis Michael Hartmann Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Burkhard Riemann Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

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Maximilian Michel Institute of Zoology, University of Cologne Germany, Cologne, Germany

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Christiane Josephine Bruns Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Hakan Alakus Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Costanza Chiapponi Department of General, Visceral, Tumor and Transplant Surgery, University Hospital Cologne, Cologne, Germany

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Trametinib: MEK1, MEK2 ATC: 16 locally advanced or metastatic BRAF V600E mutant disease ORR Phase II, single arm, open label PR: 63% CR: 6% Skin papilloma hyperkeratosis, alopecia, fatigue, fever, diarrhea, acneiform rash  Trametinib and

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0624
Volume/Issue:
Volume 11: Issue 4
Open access
Marianne C Astor Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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Kristian Løvås Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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Anette S B Wolff Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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Bjørn Nedrebø Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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Eirik Bratland Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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Jon Steen-Johnsen Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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Eystein S Husebye Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway

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supplementation  Daily oral Mg supplementation (mmol/kg per day) d 0.8–1.0 0.5 0.4 0.5 1.6  Side effects of oral Mg Diarrhea Diarrhea Diarrhea None None  Serum-Mg (mmol/l) 0.5–0.6 0.6 0.6–0.7 0.7–0.8 0.7  Urine-Mg (mmol/mmol creatinine) ref. range 0.20–0.50 0.03 0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0066
Volume/Issue:
Volume 4: Issue 4
Open access
Alberto Bongiovanni Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Federica Recine Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Flavia Foca Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Valentina Fausti Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Nada Riva Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Greta Fabbri Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Stefano Severi Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Chiara Liverani Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Alessandro De Vita Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Chiara Spadazzi Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Giacomo Miserocchi Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Laura Mercatali Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Dino Amadori Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Toni Ibrahim Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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every 4 weeks was administered in 26 patients. Treatment was very well tolerated, with only one case each of G1, G2 and G3 diarrhea recorded. G1 cholelithiasis was registered in three cases. Median OS was 5.7 years (95% CI: 4.2–7.0) in G1–G2 NEN patients

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0478
Volume/Issue:
Volume 7: Issue 12
Open access
Aaron Lerner B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
AESKU.KIPP Institute, Wendelsheim, Germany

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Patricia Jeremias AESKU.KIPP Institute, Wendelsheim, Germany

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Torsten Matthias AESKU.KIPP Institute, Wendelsheim, Germany

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’s thyroiditis Graves’ disease Weight Loss Gain Loss Bowel movement Diarrhea/constipation Constipation Diarrhea Joint/bone pain +/+ +/−, hypotonia Muscle weakness Fatigue/tiredness + + + Psychology

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0021
Volume/Issue:
Volume 6: Issue 4
Open access
Jordyn Silverstein Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Wesley Kidder Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Susan Fisher Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA

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Thomas A Hope Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA

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Samantha Maisel Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Dianna Ng Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Pathology, University of California, San Francisco, California, USA

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Jessica Van Ziffle Department of Pathology, University of California, San Francisco, California, USA

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Chloe E Atreya Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Katherine Van Loon Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA

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-limited episode of diarrhea at 25 weeks gestational age for which she was diagnosed with acute gastroenteritis. At 37 weeks, a cesarean section was performed due to arrest of descent during labor. At 2 weeks post-partum, she began experiencing copious diarrhea

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0063
Volume/Issue:
Volume 8: Issue 8
Open access
Hanbaro Kim Department of Surgery, Hallym University College of Medicine, Chuncheon, Republic of Korea

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Ki Byung Song Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Dae Wook Hwang Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Jae Hoon Lee Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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Shadi Alshammary Department of Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

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Song Cheol Kim Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

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variable clinical behavior. Functional PNETs (F-PNETs) are diagnosed on the basis of the presence of clinical symptoms such as hypoglycemia, diarrhea or peptic ulcer. Non-functional PNETs (NF-PNETs) are often discovered later, that is, at an advanced stage

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0282
Volume/Issue:
Volume 8: Issue 7
Open access