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Alberto Giacinto Ambrogio Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Massimiliano Andrioli Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Martina De Martin Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesco Cavagnini Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesca Pecori Giraldi Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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desmopressin testing, a procedure also used during the diagnostic work-up of Cushing’s disease. Administration of desmopressin, a long-acting vasopressin analog, has in fact proven useful to distinguish Cushing’s disease from pseudo-Cushing states ( 8 , 9

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S E Baldeweg Department of Diabetes and Endocrinology, University College London NHS Foundation Trust and Univeristy College London, London, UK

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S Ball Department of Medicine and Endocrinology, Manchester University Foundation Trust & Manchester Academic Health Science Centre Manchester, Manchester, UK

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A Brooke Royal Devon and Exeter NHS Foundation Trust, Exeter, UK

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H K Gleeson Department of Endocrinology, Queen Elizabeth Hospital, Birmingham, UK

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M J Levy University of Leicester and University of Leicester Hospitals Trust, Leicester, UK

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M Prentice Croydon Health Services NHS Trust, Croydon, UK

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J Wass Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology & Metabolism, Oxford, UK

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the Society for Endocrinology Clinical Committee The Society for Endocrinology, Starling House, 1600 Bristol Parkway North, Bristol, UK

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. Desmopressin (DDAVP, a synthetic AVP analogue) reduces uncontrolled water excretion in CDI and is commonly used in treatment. Critically, loss of thirst perception (through primary pathology or reduced consciousness) or limited access to water (through non

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Lingjuan Li Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Jing Qin Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Lin Ren Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Shiyuan Xiang Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Xiaoyun Cao Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China

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Xianglan Zheng Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Zhiwen Yin Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Nidan Qiao Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China

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, serum sodium level, and a need for desmopressin treatment were comprehensively evaluated for the diagnosis of central arginine vasopressin deficiency. We developed models to predict postoperative hypernatremia. In the training cohort, we used

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M de Fost Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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S M Oussaada Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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E Endert Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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G E Linthorst Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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M J Serlie Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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M R Soeters Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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J H DeVries Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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P H Bisschop Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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E Fliers Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Room F5‐164

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DI and elevated in nephrogenic DI, reflecting inappropriate AVP action. In addition, the administration of the AVP analog desmopressin acetate at the end of the test may help to differentiate central from nephrogenic DI, as the antidiuretic response

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Kush Dev Singh Jarial Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Anil Bhansali Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Vivek Gupta Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Paramjeet Singh Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Kanchan K Mukherjee Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Akhilesh Sharma Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Rakesh K Vashishtha Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Suja P Sukumar Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Naresh Sachdeva Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Rama Walia Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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(cyclical CS) ( 7 , 8 , 9 ). Ovine or hCRH and/or desmopressin have been used to stimulate corticotropes during BIPSS to improve the accuracy of the procedure for localizing the source of ACTH hypersecretion and were found to be equipotent in stimulating

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Dirk Weismann Department of Internal Medicine I, Intensivcare Unit, University Hospital of Würzburg, Würzburg, Germany

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Andreas Schneider Department of Internal Medicine I, Intensivcare Unit, University Hospital of Würzburg, Würzburg, Germany

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Charlotte Höybye Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Surgery and Medicine, Karolinska Institute, Stockholm, Sweden

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increase should be limited to 10–12 mmol/L in the first 24 h and to 8 mmol/L/day in the following days until a sNA of 130 mmol/L is obtained. Limiting the increase of sNA is difficult, but is greatly facilitated by the introduction of desmopressin (see the

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Muhammad Fahad Arshad Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield, UK
Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, UK

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Ahmed Iqbal Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield, UK
Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, UK

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James Weeks Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield, UK

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Ines Fonseca Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield, UK

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Alia Munir Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield, UK

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William Bennet Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield, UK

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) of the total cohort (i.v. dextrose = 17, desmopressin = 2, both = 3). These were mostly provided outside of general wards, especially desmopressin which was given exclusively in high dependency/intensive care units. Details of the patients who

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Benedetta Zampetti Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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Erika Grossrubatscher Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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Paolo Dalino Ciaramella Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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Edoardo Boccardi Department of Neuroradiology, Ospedale Niguarda, Milano, Italy

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Paola Loli Department of Endocrinology, Ospedale Niguarda, Milano, Italy

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ratio >2. * Stimulation with desmopressin. ** Stimulation with CRH+desmopressin. *** Not known if procedures were done with or without use of CRH. **** Not known if procedures were done with CRH or desmopressin. ° None pathologically

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Pablo Abellán-Galiana Department of Endocrinology, Hospital General Universitari de Castelló, Castellón, Spain
Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Castellón, Spain

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Carmen Fajardo-Montañana Department of Endocrinology, Hospital Universitario de la Ribera, Alzira, Spain

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Pedro Riesgo-Suárez Department of Neurosurgery, Hospital Universitario de la Ribera, Alzira, Spain

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Marcelino Pérez-Bermejo Department of Nursing, Universidad Católica de Valencia, Valencia, Spain

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Celia Ríos-Pérez Centro de Salud Tavernes de la Valldigna, Hospital Comarcal Francesc de Borja, Gandía, Spain

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José Gómez-Vela Department of Endocrinology, Hospital Universitario de la Ribera, Alzira, Spain

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results of postoperative basal cortisol, among which are: corticotropin-releasing hormone test ( 27 ), metyrapone test ( 28 ), desmopressin test ( 29 , 30 ) and dexamethasone suppression test after desmopressin ( 31 ). For the interpretation of these last

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Jingya Zhou Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Collaborating Center for the WHO Family of International Classifications in China, Beijing, China

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Meng Zhang Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Collaborating Center for the WHO Family of International Classifications in China, Beijing, China

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Lin Lu Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Key Laboratory of Endocrinology of National Health Commission of People’s Republic of China, Beijing, China

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Xiaopeng Guo Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Lu Gao Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Weigang Yan Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Haiyu Pang Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Yi Wang Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Collaborating Center for the WHO Family of International Classifications in China, Beijing, China

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Bing Xing Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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-enhanced MRI of the pituitary glands and plain and contrasted enhanced computed tomography (CT) of the adrenal, thoracoabdominal and pelvic areas. Since bilateral inferior petrosal sinus sampling (BIPSS) with desmopressin (DDAVP) has been demonstrated to have

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